ID   SYI_ANTLO               Reviewed;         628 AA.
AC   Q27707;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Isoleucyl-tRNA synthetase;
DE            EC=6.1.1.5;
DE   AltName: Full=Isoleucine--tRNA ligase;
DE            Short=IleRS;
DE   Flags: Fragment;
OS   Antonospora locustae (Nosema locustae).
OC   Eukaryota; Fungi; Microsporidia; Antonospora.
OX   NCBI_TaxID=278021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95223956; PubMed=7708661; DOI=10.1073/pnas.92.7.2441;
RA   Brown J.R., Doolittle W.F.;
RT   "Root of the universal tree of life based on ancient aminoacyl-tRNA
RT   synthetase gene duplications.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:2441-2445(1995).
CC   -!- CATALYTIC ACTIVITY: ATP + L-isoleucine + tRNA(Ile) = AMP +
CC       diphosphate + L-isoleucyl-tRNA(Ile).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; L37097; AAC41564.1; -; Genomic_DNA.
DR   HSSP; P56690; 1ILE.
DR   BRENDA; 6.1.1.5; 288911.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR015905; Ile-tRNA-synt_Ia_N.
DR   InterPro; IPR018353; Isoleucyl-tRNA_synthetase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR013155; V/L/I-tRNA-synth_anticodon-bd.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   PANTHER; PTHR11946:SF9; Ile-tRNA-synt_Ia; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; PARTIAL.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Ligase; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN        <1   >628       Isoleucyl-tRNA synthetase.
FT                                /FTId=PRO_0000098601.
FT   MOTIF       505    509       "KMSKS" region.
FT   BINDING     508    508       ATP (By similarity).
FT   NON_TER       1      1
FT   NON_TER     628    628
SQ   SEQUENCE   628 AA;  73774 MW;  8FCFCAD43362C35E CRC64;
     WDRHGVPVEY EIDKALGITG VKDIHDMGIR KYNKECRKIV LRYTKEWEAV VKRMGRWIDF
     RNGYRTMDRS FMESIWHIFK MLYEKGSVYR GHRVMPYSTA CSTPLSNFEA NQNYKDVSDP
     SILVAFPLRK PFKGYSLSLV AWTTTPWTLP SHMAILVNQS FIYAIFRLKS AFFIMQRDRV
     NVYFKDAVVI SEVKGHELLH LEHDQPFMYY NHYREKGFFR VYHADFVSEI DGTGVVHCSP
     GFGEDDYKAM TMPGLIKENE LLPSPLDENG RFNEEVPEYK GMHVKDADQS IIKDLGKKIL
     YEGKVYHRYP FCWRSDTPLI YKLVPNWFVR VKREIPRLLE SNSTINWIPE SIGEHKFKNW
     LSEARDWSIS RNRFWGTPIP LWHCDGKYIC IGSIEELSRL SGRKIDDIHR ENVDDVVICK
     DGEKYRRIEE VFDCWFESGC MPYAQRHWPF ECDNLCLPAD FVAEGVDQTR GWFYTMHVIS
     TVLLAKPRFR NCIVNGIVLA SDKKKMSKRL KNYPDPMDVI NRYSADSLRL YLISSPVVMA
     ENMCFSEEGV GEVLKTLLIP WYNCIYFYSE CPNAGDQEQT RMDDWILNTL NTFGNKVKRD
     MSKYMLQGVM GYATSFVNDL SNWYIRLN
//