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Protein

Isoleucine--tRNA ligase

Gene
N/A
Organism
Antonospora locustae (Microsporidian parasite) (Nosema locustae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei508ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
OrganismiAntonospora locustae (Microsporidian parasite) (Nosema locustae)
Taxonomic identifieri278021 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaAntonospora

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000098601‹1 – ›628Isoleucine--tRNA ligaseAdd BLAST›628

Proteomic databases

PRIDEiQ27707

Structurei

3D structure databases

ProteinModelPortaliQ27707
SMRiQ27707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi505 – 509"KMSKS" region5

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002301 Ile-tRNA-ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00392 ileS, 1 hit

Sequencei

Sequence statusi: Fragment.

Q27707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
WDRHGVPVEY EIDKALGITG VKDIHDMGIR KYNKECRKIV LRYTKEWEAV
60 70 80 90 100
VKRMGRWIDF RNGYRTMDRS FMESIWHIFK MLYEKGSVYR GHRVMPYSTA
110 120 130 140 150
CSTPLSNFEA NQNYKDVSDP SILVAFPLRK PFKGYSLSLV AWTTTPWTLP
160 170 180 190 200
SHMAILVNQS FIYAIFRLKS AFFIMQRDRV NVYFKDAVVI SEVKGHELLH
210 220 230 240 250
LEHDQPFMYY NHYREKGFFR VYHADFVSEI DGTGVVHCSP GFGEDDYKAM
260 270 280 290 300
TMPGLIKENE LLPSPLDENG RFNEEVPEYK GMHVKDADQS IIKDLGKKIL
310 320 330 340 350
YEGKVYHRYP FCWRSDTPLI YKLVPNWFVR VKREIPRLLE SNSTINWIPE
360 370 380 390 400
SIGEHKFKNW LSEARDWSIS RNRFWGTPIP LWHCDGKYIC IGSIEELSRL
410 420 430 440 450
SGRKIDDIHR ENVDDVVICK DGEKYRRIEE VFDCWFESGC MPYAQRHWPF
460 470 480 490 500
ECDNLCLPAD FVAEGVDQTR GWFYTMHVIS TVLLAKPRFR NCIVNGIVLA
510 520 530 540 550
SDKKKMSKRL KNYPDPMDVI NRYSADSLRL YLISSPVVMA ENMCFSEEGV
560 570 580 590 600
GEVLKTLLIP WYNCIYFYSE CPNAGDQEQT RMDDWILNTL NTFGNKVKRD
610 620
MSKYMLQGVM GYATSFVNDL SNWYIRLN
Length:628
Mass (Da):73,774
Last modified:November 1, 1996 - v1
Checksum:i8FCFCAD43362C35E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei6281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37097 Genomic DNA Translation: AAC41564.1

Similar proteinsi

Entry informationi

Entry nameiSYI_ANTLO
AccessioniPrimary (citable) accession number: Q27707
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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