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Q27707

- SYI_ANTLO

UniProt

Q27707 - SYI_ANTLO

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Protein

Isoleucine--tRNA ligase

Gene
N/A
Organism
Antonospora locustae (Microsporidian parasite) (Nosema locustae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei508 – 5081ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
OrganismiAntonospora locustae (Microsporidian parasite) (Nosema locustae)
Taxonomic identifieri278021 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaAntonospora

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›628›628Isoleucine--tRNA ligasePRO_0000098601Add
BLAST

Proteomic databases

PRIDEiQ27707.

Structurei

3D structure databases

ProteinModelPortaliQ27707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi505 – 5095"KMSKS" region

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q27707-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
WDRHGVPVEY EIDKALGITG VKDIHDMGIR KYNKECRKIV LRYTKEWEAV
60 70 80 90 100
VKRMGRWIDF RNGYRTMDRS FMESIWHIFK MLYEKGSVYR GHRVMPYSTA
110 120 130 140 150
CSTPLSNFEA NQNYKDVSDP SILVAFPLRK PFKGYSLSLV AWTTTPWTLP
160 170 180 190 200
SHMAILVNQS FIYAIFRLKS AFFIMQRDRV NVYFKDAVVI SEVKGHELLH
210 220 230 240 250
LEHDQPFMYY NHYREKGFFR VYHADFVSEI DGTGVVHCSP GFGEDDYKAM
260 270 280 290 300
TMPGLIKENE LLPSPLDENG RFNEEVPEYK GMHVKDADQS IIKDLGKKIL
310 320 330 340 350
YEGKVYHRYP FCWRSDTPLI YKLVPNWFVR VKREIPRLLE SNSTINWIPE
360 370 380 390 400
SIGEHKFKNW LSEARDWSIS RNRFWGTPIP LWHCDGKYIC IGSIEELSRL
410 420 430 440 450
SGRKIDDIHR ENVDDVVICK DGEKYRRIEE VFDCWFESGC MPYAQRHWPF
460 470 480 490 500
ECDNLCLPAD FVAEGVDQTR GWFYTMHVIS TVLLAKPRFR NCIVNGIVLA
510 520 530 540 550
SDKKKMSKRL KNYPDPMDVI NRYSADSLRL YLISSPVVMA ENMCFSEEGV
560 570 580 590 600
GEVLKTLLIP WYNCIYFYSE CPNAGDQEQT RMDDWILNTL NTFGNKVKRD
610 620
MSKYMLQGVM GYATSFVNDL SNWYIRLN
Length:628
Mass (Da):73,774
Last modified:November 1, 1996 - v1
Checksum:i8FCFCAD43362C35E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei628 – 6281

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37097 Genomic DNA. Translation: AAC41564.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37097 Genomic DNA. Translation: AAC41564.1 .

3D structure databases

ProteinModelPortali Q27707.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q27707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications."
    Brown J.R., Doolittle W.F.
    Proc. Natl. Acad. Sci. U.S.A. 92:2441-2445(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSYI_ANTLO
AccessioniPrimary (citable) accession number: Q27707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3