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Q27707 (SYI_ANTLO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isoleucine--tRNA ligase

EC=6.1.1.5
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name=IleRS
OrganismAntonospora locustae (Microsporidian parasite) (Nosema locustae)
Taxonomic identifier278021 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaAntonospora

Protein attributes

Sequence length628 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›628›628Isoleucine--tRNA ligase
PRO_0000098601

Regions

Motif505 – 5095"KMSKS" region

Sites

Binding site5081ATP By similarity

Experimental info

Non-terminal residue11
Non-terminal residue6281

Sequences

Sequence LengthMass (Da)Tools
Q27707 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8FCFCAD43362C35E

FASTA62873,774
        10         20         30         40         50         60 
WDRHGVPVEY EIDKALGITG VKDIHDMGIR KYNKECRKIV LRYTKEWEAV VKRMGRWIDF 

        70         80         90        100        110        120 
RNGYRTMDRS FMESIWHIFK MLYEKGSVYR GHRVMPYSTA CSTPLSNFEA NQNYKDVSDP 

       130        140        150        160        170        180 
SILVAFPLRK PFKGYSLSLV AWTTTPWTLP SHMAILVNQS FIYAIFRLKS AFFIMQRDRV 

       190        200        210        220        230        240 
NVYFKDAVVI SEVKGHELLH LEHDQPFMYY NHYREKGFFR VYHADFVSEI DGTGVVHCSP 

       250        260        270        280        290        300 
GFGEDDYKAM TMPGLIKENE LLPSPLDENG RFNEEVPEYK GMHVKDADQS IIKDLGKKIL 

       310        320        330        340        350        360 
YEGKVYHRYP FCWRSDTPLI YKLVPNWFVR VKREIPRLLE SNSTINWIPE SIGEHKFKNW 

       370        380        390        400        410        420 
LSEARDWSIS RNRFWGTPIP LWHCDGKYIC IGSIEELSRL SGRKIDDIHR ENVDDVVICK 

       430        440        450        460        470        480 
DGEKYRRIEE VFDCWFESGC MPYAQRHWPF ECDNLCLPAD FVAEGVDQTR GWFYTMHVIS 

       490        500        510        520        530        540 
TVLLAKPRFR NCIVNGIVLA SDKKKMSKRL KNYPDPMDVI NRYSADSLRL YLISSPVVMA 

       550        560        570        580        590        600 
ENMCFSEEGV GEVLKTLLIP WYNCIYFYSE CPNAGDQEQT RMDDWILNTL NTFGNKVKRD 

       610        620 
MSKYMLQGVM GYATSFVNDL SNWYIRLN 

« Hide

References

[1]"Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications."
Brown J.R., Doolittle W.F.
Proc. Natl. Acad. Sci. U.S.A. 92:2441-2445(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37097 Genomic DNA. Translation: AAC41564.1.

3D structure databases

ProteinModelPortalQ27707.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ27707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSPR00984. TRNASYNTHILE.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00392. ileS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYI_ANTLO
AccessionPrimary (citable) accession number: Q27707
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries