Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q27707

- SYI_ANTLO

UniProt

Q27707 - SYI_ANTLO

Protein

Isoleucine--tRNA ligase

Gene
N/A
Organism
Antonospora locustae (Microsporidian parasite) (Nosema locustae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei508 – 5081ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoleucine--tRNA ligase (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    OrganismiAntonospora locustae (Microsporidian parasite) (Nosema locustae)
    Taxonomic identifieri278021 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaAntonospora

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›628›628Isoleucine--tRNA ligasePRO_0000098601Add
    BLAST

    Proteomic databases

    PRIDEiQ27707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27707.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi505 – 5095"KMSKS" region

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q27707-1 [UniParc]FASTAAdd to Basket

    « Hide

    WDRHGVPVEY EIDKALGITG VKDIHDMGIR KYNKECRKIV LRYTKEWEAV    50
    VKRMGRWIDF RNGYRTMDRS FMESIWHIFK MLYEKGSVYR GHRVMPYSTA 100
    CSTPLSNFEA NQNYKDVSDP SILVAFPLRK PFKGYSLSLV AWTTTPWTLP 150
    SHMAILVNQS FIYAIFRLKS AFFIMQRDRV NVYFKDAVVI SEVKGHELLH 200
    LEHDQPFMYY NHYREKGFFR VYHADFVSEI DGTGVVHCSP GFGEDDYKAM 250
    TMPGLIKENE LLPSPLDENG RFNEEVPEYK GMHVKDADQS IIKDLGKKIL 300
    YEGKVYHRYP FCWRSDTPLI YKLVPNWFVR VKREIPRLLE SNSTINWIPE 350
    SIGEHKFKNW LSEARDWSIS RNRFWGTPIP LWHCDGKYIC IGSIEELSRL 400
    SGRKIDDIHR ENVDDVVICK DGEKYRRIEE VFDCWFESGC MPYAQRHWPF 450
    ECDNLCLPAD FVAEGVDQTR GWFYTMHVIS TVLLAKPRFR NCIVNGIVLA 500
    SDKKKMSKRL KNYPDPMDVI NRYSADSLRL YLISSPVVMA ENMCFSEEGV 550
    GEVLKTLLIP WYNCIYFYSE CPNAGDQEQT RMDDWILNTL NTFGNKVKRD 600
    MSKYMLQGVM GYATSFVNDL SNWYIRLN 628
    Length:628
    Mass (Da):73,774
    Last modified:November 1, 1996 - v1
    Checksum:i8FCFCAD43362C35E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei628 – 6281

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37097 Genomic DNA. Translation: AAC41564.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37097 Genomic DNA. Translation: AAC41564.1 .

    3D structure databases

    ProteinModelPortali Q27707.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q27707.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications."
      Brown J.R., Doolittle W.F.
      Proc. Natl. Acad. Sci. U.S.A. 92:2441-2445(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSYI_ANTLO
    AccessioniPrimary (citable) accession number: Q27707
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3