Reviewed, UniProtKB/Swiss-Prot Q27685 (PGKC_LEIME)

Names and origin

Protein names

Recommended name:
    Phosphoglycerate kinase, glycosomal
      Short name=Phosphoglycerate kinase C
    EC=2.7.2.3

Gene names

Name:

PGKC

Organism

Leishmania mexicana

Taxonomic identifier

5665 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Subunit structure	Monomer By similarity.
Subcellular location	Glycosome.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Glycosome Peroxisome
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Phosphoglycerate kinase, glycosomal		PRO_0000145856
Regions
	Nucleotide binding	372 – 375	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	62 – 65	4	Substrate binding By similarity
Sites
	Binding site	39	1	Substrate By similarity
	Binding site	132	1	Substrate By similarity
	Binding site	169	1	Substrate By similarity
	Binding site	220	1	ATP By similarity
	Binding site	342	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27685-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 03C3B8B12DF7DAB4	FASTA	479	51,499
	10 20 30 40 50 60 MSLVLKKSID DVALKDKKVL IRVDFNVPVK NGEITNDFRI RSALPTIQKV LKEGGSCILM 70 80 90 100 110 120 SHLGRPKGAR MSDPKPEKGV RGYEEAATLR PVAAALSELL EKKVAFAPDC LNASIYVSKL 130 140 150 160 170 180 KRGDVLLLEN VRFYTEEGSK KEEEADAMAK VLASYADLYV SDAFGTAHRD SATMTGIPKV 190 200 210 220 230 240 LGSGYAGYLM EKEINYFSRV LNNPPRPLVA IVGGAKVSDK IELLDNMLGR INYLVIGGAM 250 260 270 280 290 300 AYTFQKAQGR KIGISMCEED KLDLAKSLLK KAQERGVQVL LPVDHVCNKE FKAVDSPLVT 310 320 330 340 350 360 EDVDVPDGYM ALDIGPKTIH MYEEVIGRCK SAIWNGPMGV FEMPCYSKGT FAVAKAMGTG 370 380 390 400 410 420 TQKDGLLSII GGGDTASAAE LSGEAKNMSH VSTGGGASLE LLEGKTLPGV AILTDKEVKG 430 440 450 460 470 RGPLLKCACG GASPSNESCP RRREGIWGGG FIVTEIVKLV GALLIGIFIG RRLNTKLIR

References

[1]

"Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania mexicana mexicana." Adje C.A., Opperdoes F.R., Michels P.A.M. Mol. Biochem. Parasitol. 90:155-168(1997) [PubMed: 9497040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MHOM/BZ/84/BEL46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X98487 Genomic DNA. Translation: CAA67113.1.
3D structure databases
HSSP	HSSP built from PDB template 16PK based on UniProtKB P07378.
SMR	Q27685. Positions 6-416.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.2.3. 1480.
Family and domain databases
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PRINTS	PR00477. PHGLYCKINASE.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGKC_LEIME

Accession

Primary (citable) accession number: Q27685

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)