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Q27683

- PGKB_LEIMA

UniProt

Q27683 - PGKB_LEIMA

Protein

Phosphoglycerate kinase, cytosolic

Gene

PGKB

Organism
Leishmania major
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei132 – 1321SubstrateBy similarity
    Binding sitei169 – 1691SubstrateBy similarity
    Binding sitei220 – 2201ATPBy similarity
    Binding sitei342 – 3421ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi372 – 3754ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase, cytosolic (EC:2.7.2.3)
    Alternative name(s):
    Phosphoglycerate kinase B
    cPGK
    Gene namesi
    Name:PGKB
    OrganismiLeishmania major
    Taxonomic identifieri5664 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Phosphoglycerate kinase, cytosolicPRO_0000145853Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ27683.
    SMRiQ27683. Positions 6-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni62 – 654Substrate bindingBy similarity

    Domaini

    This cytosolic PGK lacks a C-terminal extension of 38 AA which is present in the glycosomal isoenzyme.

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27683-1 [UniParc]FASTAAdd to Basket

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    MSLVLKKSID DATVRDKKVL IRVDFNVPVK NGKITNDFRI RSALPTIQKV    50
    LKEGGSCILM SHLGRPKGAR MSDPSPEKGV RGYEEAATLR PVAARISELL 100
    GQKVEFAPDC LDAASYASKL KNADVLLLEN VRFYAEEGSK KEEERDAMAK 150
    VLASYGDVYV SDAFGTAHRD SATMTGIPKV LGAGYAGYLM EKEINYFSRV 200
    LNNPPRPLVA IVGGAKVSDK IQLLDNMLGR INYLVIGGAM AYTFQKAQGR 250
    KIGISMCEED KLDLAKSLLK KAQERNVQVF LPVDHVCNKE FKAADSPLVT 300
    ESVDVPDGYM ALDIGPRTIH MYEEVIGRCK SAIWNGPMGV FEMPCYSKGT 350
    FAVAKAMGTG TQKNGLMSII GGGDSASAAE LSGEAKNMSH VSTGGGASLE 400
    LLEGKTLPGV AILTDRE 417
    Length:417
    Mass (Da):44,963
    Last modified:November 1, 1996 - v1
    Checksum:i9EB46B3375FED6D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25120 Genomic DNA. Translation: AAC12658.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25120 Genomic DNA. Translation: AAC12658.1 .

    3D structure databases

    ProteinModelPortali Q27683.
    SMRi Q27683. Positions 6-416.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of phosphoglycerate kinase genes in Leishmania major and evidence for the absence of a third closely related gene or isoenzyme."
      McKoy G.E.M., Badal M., Prescott Q., Lux H., Hart D.T.
      Mol. Biochem. Parasitol. 90:169-181(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MHOM/IL/81/Friedlin.
    2. Erratum
      McKoy G.E.M., Badal M., Prescott Q., Lux H., Hart D.T.
      Mol. Biochem. Parasitol. 93:161-161(1998)

    Entry informationi

    Entry nameiPGKB_LEIMA
    AccessioniPrimary (citable) accession number: Q27683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3