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Q27677 (ACES_LEPDE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Rapidly hydrolyzes choline released into the synapse.

Catalytic activity

Acetylcholine + H2O = choline + acetate.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cell junctionsynapse By similarity. Cell membrane; Lipid-anchorGPI-anchor By similarity. Note: Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor By similarity.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 605567Acetylcholinesterase
PRO_0000008607
Propeptide606 – 62924Removed in mature form Potential
PRO_0000008608

Sites

Active site2531Acyl-ester intermediate By similarity
Active site3821Charge relay system By similarity
Active site4961Charge relay system By similarity

Amino acid modifications

Lipidation6051GPI-anchor amidated serine Potential
Glycosylation1251N-linked (GlcNAc...) By similarity
Glycosylation3081N-linked (GlcNAc...) By similarity
Glycosylation4181N-linked (GlcNAc...) By similarity
Glycosylation5091N-linked (GlcNAc...) By similarity
Disulfide bond103 ↔ 130 By similarity
Disulfide bond307 ↔ 322 By similarity
Disulfide bond458 ↔ 574 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27677 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 06556F833EB16C72

FASTA62971,142
        10         20         30         40         50         60 
MGQLSILCLF VTVCASVCGY SWPSDETTTK PSQFKDFHTD PLVVETTSGL VRGYSKTVLG 

        70         80         90        100        110        120 
REVHVFTGIP FAKPPIEQLR FKKPVPIDPW HGILDATKQP NSCFQERYEY FPGFEGEEMW 

       130        140        150        160        170        180 
NPNTNISEDC LYLNIWVPQR LRIRHHADKP TIDRPKVPVL IWIYGGGYMS GTATLDVYDA 

       190        200        210        220        230        240 
DIIAATSDVI VASMQYRLGS FGFLYLNRYF PRGSDETPGN MGLWDQILAI RWIKDNAAAF 

       250        260        270        280        290        300 
GGDPDLITLF GESAGGGSIS IHLISPVTKG LVRRGIMQSG TMNAPWSYMS GERAEQIGKI 

       310        320        330        340        350        360 
LIQDCGCNVS LLENSPRKVM DCMRAVDAKT ISLQQWNSYS GILGFPSTPT IEGVLLPKHP 

       370        380        390        400        410        420 
MDMLAEGDYE DMEILLGSNH DEGTYFLLYD FIDFFEKDGP SFLQREKYHD IIDTIFKNMS 

       430        440        450        460        470        480 
RLERDAIVFQ YTNWEHVHDG YLNQKMIGDV VGDYFFVCPT NNFAEVAADR GMKVFYYYFT 

       490        500        510        520        530        540 
HRTSTSLWGE WMGVIHGDEV EYVFGHPLNM SLQFNSRERE LSLKIMQAFA RFATTGKPVT 

       550        560        570        580        590        600 
DDVNWPLYTK DQPQYFIFNA DKNGIGKGPR ATACAFWNDF LPKLRDNSGS EEAPCVNTYL 

       610        620 
SKIRSSSNEL LPPSTSLVLI WIMTLLNAL 

« Hide

References

[1]"Cloning and sequencing of a cDNA encoding acetylcholinesterase in Colorado potato beetle, Leptinotarsa decemlineata (Say)."
Zhu K.Y., Clark J.M.
Insect Biochem. Mol. Biol. 25:1129-1138(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SS.
Tissue: Larva and Pupae.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41180 mRNA. Translation: AAB00466.1.

3D structure databases

ProteinModelPortalQ27677.
SMRQ27677. Positions 40-585.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001445. Acylcholinesterase_insect.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00880. ACHEINSECT.
PR00878. CHOLNESTRASE.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACES_LEPDE
AccessionPrimary (citable) accession number: Q27677
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families