Receptor-type adenylate cyclase A

Preferred order of sections

Names and origin

Protein names

Recommended name:
Receptor-type adenylate cyclase A
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:

RAC-A

Organism

Leishmania donovani

Taxonomic identifier

5661 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	1380 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could act as a receptor for a unknown ligand.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Developmental stage	Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase Receptor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1380

1380

Receptor-type adenylate cyclase A

PRO_0000195734

Regions

Topological domain

1 – 34

34

Cytoplasmic Potential

Transmembrane

35 – 55

21

Helical; Potential

Topological domain

56 – 891

836

Extracellular Potential

Transmembrane

892 – 912

21

Helical; Potential

Topological domain

913 – 1380

468

Cytoplasmic Potential

Domain

933 – 1087

155

Guanylate cyclase

Sites

Metal binding

938

1

Magnesium By similarity

Metal binding

981

1

Magnesium By similarity

Amino acid modifications

Glycosylation

422

1

N-linked (GlcNAc...) Potential

Glycosylation

478

1

N-linked (GlcNAc...) Potential

Glycosylation

497

1

N-linked (GlcNAc...) Potential

Glycosylation

567

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q27675 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6B2D5F7D3C1107A0
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FASTA

1,380

151,694

        10         20         30         40         50         60 
MAMQIRPSLG GCLRHGGAGD HAARRLSRLR AAKVFVPTAV VCVLLCCAPW VMAEITNDAE 

        70         80         90        100        110        120 
REPVYILNAM YSTEAYTNED AKALWTGMDM AFYNSHYKAA GGRPIKILHP DPDQDNLYDI 

       130        140        150        160        170        180 
AEVILHSLAR QEKLLAVLGP YLDGRLTAAL SNADVVQSGL MLIAPFTGSS GVRTWSDSVY 

       190        200        210        220        230        240 
FTRAEPMVEL KVVLMHIVNR LRARRVAFMR LTGMHFGGEE LTYVQDTLTS LLRDPAVLYT 

       250        260        270        280        290        300 
VPYSESSVEV DEEAFDAMAD TNPQVIIVWA APVQQVIYFL EKVLTDPRTS SAYVISCSMI 

       310        320        330        340        350        360 
QRVVFDVYKR LLSAGSIKPQ DGRILASATT SPVSGEGLKY MEVLKAQMSN YIENSGSFDY 

       370        380        390        400        410        420 
YPDDDSTETL GRKARSEAPL SRKYTVDEFF QAHPSIAKLM ALGWLSGTLV QQTLEQTDWI 

       430        440        450        460        470        480 
VNRSTYKAGL FNQNRFVIGG DYVLGDYGGP CEPLAQFLGA SCYCNQGGHS SILTVLQNAS 

       490        500        510        520        530        540 
WDIVPDSSFK YPQSECNSSK SQIVKAVSVL ALLNQGYPKL IDAGMQLNEV LPHAFDDNLC 

       550        560        570        580        590        600 
KGYKVSSIFL RVETAKAQQL FDAEVSNYSV DIIAGPIFQA LDVGEIFVLN PLYNHPQLRT 

       610        620        630        640        650        660 
EKRNYVYLMP TLEQQIYVMY SKIDALRTRT DVFEDTAVVL RGYSAQEVVE ISEILFKTAG 

       670        680        690        700        710        720 
TFNLPDPSVA TISFTDSLRG LLSPRAINVV IGMKDGDSAH FANFLAKYTD VMVVVCFDEL 

       730        740        750        760        770        780 
TMYYEELRAT FSVQPTSVQA RLMSFSSLPL WTDASAEAKA RWPILGHFHK IFPDPINHTP 

       790        800        810        820        830        840 
SLLRDVIIAG FIQELVSTTT VAETKLLTNA VYINGGVTTY GFTLGNFEWG CTATTSGDSC 

       850        860        870        880        890        900 
VYKNYGASNI EILSIQRMLD PTVPQLSSPS TPTMEYRPRQ RSHALTPAQR NGLIAGCVVG 

       910        920        930        940        950        960 
AVVLIATCTL LLYCCMDNRN NDAAPKDGDE PVTLLFTDIE SSTALWAALP QLMSDAIAAH 

       970        980        990       1000       1010       1020 
HRVIRQLVKK YGCYEVKTIG DSFMIACRSA HSAVSLACEI QTKLLKHDWG TEALDRAYRE 

      1030       1040       1050       1060       1070       1080 
FELARVDTLD DYEPPTARLS EEEYAALWCG LRVRVGIHTG LTDIRYDEVT KGYDYYGDTS 

      1090       1100       1110       1120       1130       1140 
NMAARTEAVA NGGQVVATEA AWWALSNDER AGIAHTAMGP QGLRGVPFAV EMFQLNAVPG 

      1150       1160       1170       1180       1190       1200 
RRHAALRTEI EAILPDDTAT DTASSAAGAL LSSVETMSDP AAGIAFVLAS CFAPYPVAQR 

      1210       1220       1230       1240       1250       1260 
VRELQPLLSK WGVGAPPRSR LVSEEDYCQG LMNRLAIRIA TVSQARLRLT REDAADGKFK 

      1270       1280       1290       1300       1310       1320 
LASSEALNPL AREGDSAAGG VRPRLPGSPV TSLPAGGSSS MREWRVFTRL MNDTQHPSVT 

      1330       1340       1350       1360       1370       1380 
HLSQQRPSNL TSFTEAQDAA FPLNAHCGPE SRVENSGADD EEIVIVRVSR NPHYARHAFE

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References

[1]	"A family of putative receptor-adenylate cyclases from Leishmania donovani." Sanchez M.A., Zeoli D., Klamo E.M., Kavanaugh M.P., Landfear S.M. J. Biol. Chem. 270:17551-17558(1995) [PubMed: 7615561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MHOM/SD/62/1S.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U17042 Genomic DNA. Translation: AAA74998.1.
PIR	T18309.
3D structure databases
ProteinModelPortal	Q27675.
SMR	Q27675. Positions 920-1151.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit.
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_LEIDO

Accession

Primary (citable) accession number: Q27675

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry information

Relevant documents