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Q27664

- CP6B2_HELAM

UniProt

Q27664 - CP6B2_HELAM

Protein

Cytochrome P450 6B2

Gene

CYP6B2

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6B2 (EC:1.14.14.1)
    Alternative name(s):
    CYPVIB2
    Gene namesi
    Name:CYP6B2
    OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
    Taxonomic identifieri29058 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 6B2PRO_0000051894Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital and the insecticide permethrin.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27664.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27664-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWIFYFPAVI SVLIVTLYFY FTRTFNYWKK RNVRGPEPVV FFGNLKDSAL    50
    RKKNMGVVME ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV 100
    FSDRGLEFSK EGLGQNLFHA DGDTWRTLRN RFTPIFTSGK LKNMFYLMNE 150
    GADNFIDHVS KECEKHQEFE IHTLLQTYTM STISSCAFGV SYDTISDKLD 200
    TLAIVDKIIS EPSYAIELDM MYPGLLPKLN LSIFPSVVHK FFKNLVNTIV 250
    TQRNGKPSGR NDFMDLILEL RQMGEITSNK YGNNMSTLEI TESVMCAQAF 300
    VFYIAGYETS ATTMAYLTYQ LALNPDIQNK LIAEIDEAIK ANGGKVTYDT 350
    VKDMKYLNKV FDETLRMYSI VEPLQRKAIR DYKLPGTDVV IEKDTVVLIS 400
    PRGIHYDPKY YDNPKQFNPE RFFAEEVGKR HPCAYLPFGL GQRNCIGMRF 450
    GRLQSLLCIT KLLSKFRLEP SKNTDRNLQV EPYRFIIGPK GGIRLNIVPR 500
    KDVS 504
    Length:504
    Mass (Da):58,218
    Last modified:November 1, 1996 - v1
    Checksum:iC0BDF218509A8849
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061L → V.
    Natural varianti115 – 1151Q → S.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18085 mRNA. Translation: AAB60252.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18085 mRNA. Translation: AAB60252.1 .

    3D structure databases

    ProteinModelPortali Q27664.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of a cDNA clone for a pyrethroid inducible cytochrome P450 from Helicoverpa armigera."
      Wang X.P., Hobbs A.A.
      Insect Biochem. Mol. Biol. 25:1001-1009(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Midgut.

    Entry informationi

    Entry nameiCP6B2_HELAM
    AccessioniPrimary (citable) accession number: Q27664
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3