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Q27664

- CP6B2_HELAM

UniProt

Q27664 - CP6B2_HELAM

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Protein

Cytochrome P450 6B2

Gene

CYP6B2

Organism
Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B2 (EC:1.14.14.1)
Alternative name(s):
CYPVIB2
Gene namesi
Name:CYP6B2
OrganismiHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifieri29058 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 6B2PRO_0000051894Add
BLAST

Expressioni

Inductioni

By phenobarbital and the insecticide permethrin.

Structurei

3D structure databases

ProteinModelPortaliQ27664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27664-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWIFYFPAVI SVLIVTLYFY FTRTFNYWKK RNVRGPEPVV FFGNLKDSAL
60 70 80 90 100
RKKNMGVVME ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV
110 120 130 140 150
FSDRGLEFSK EGLGQNLFHA DGDTWRTLRN RFTPIFTSGK LKNMFYLMNE
160 170 180 190 200
GADNFIDHVS KECEKHQEFE IHTLLQTYTM STISSCAFGV SYDTISDKLD
210 220 230 240 250
TLAIVDKIIS EPSYAIELDM MYPGLLPKLN LSIFPSVVHK FFKNLVNTIV
260 270 280 290 300
TQRNGKPSGR NDFMDLILEL RQMGEITSNK YGNNMSTLEI TESVMCAQAF
310 320 330 340 350
VFYIAGYETS ATTMAYLTYQ LALNPDIQNK LIAEIDEAIK ANGGKVTYDT
360 370 380 390 400
VKDMKYLNKV FDETLRMYSI VEPLQRKAIR DYKLPGTDVV IEKDTVVLIS
410 420 430 440 450
PRGIHYDPKY YDNPKQFNPE RFFAEEVGKR HPCAYLPFGL GQRNCIGMRF
460 470 480 490 500
GRLQSLLCIT KLLSKFRLEP SKNTDRNLQV EPYRFIIGPK GGIRLNIVPR

KDVS
Length:504
Mass (Da):58,218
Last modified:November 1, 1996 - v1
Checksum:iC0BDF218509A8849
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061L → V.
Natural varianti115 – 1151Q → S.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18085 mRNA. Translation: AAB60252.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18085 mRNA. Translation: AAB60252.1 .

3D structure databases

ProteinModelPortali Q27664.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence analysis of a cDNA clone for a pyrethroid inducible cytochrome P450 from Helicoverpa armigera."
    Wang X.P., Hobbs A.A.
    Insect Biochem. Mol. Biol. 25:1001-1009(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Midgut.

Entry informationi

Entry nameiCP6B2_HELAM
AccessioniPrimary (citable) accession number: Q27664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3