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Q27664 (CP6B2_HELAM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 6B2

EC=1.14.14.1
Alternative name(s):
CYPVIB2
Gene names
Name:CYP6B2
OrganismHelicoverpa armigera (Cotton bollworm) (Heliothis armigera)
Taxonomic identifier29058 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHelicoverpa

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Induction

By phenobarbital and the insecticide permethrin.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityPolymorphism
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 6B2
PRO_0000051894

Sites

Metal binding4451Iron (heme axial ligand) By similarity

Natural variations

Natural variant1061L → V.
Natural variant1151Q → S.

Sequences

Sequence LengthMass (Da)Tools
Q27664 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C0BDF218509A8849

FASTA50458,218
        10         20         30         40         50         60 
MWIFYFPAVI SVLIVTLYFY FTRTFNYWKK RNVRGPEPVV FFGNLKDSAL RKKNMGVVME 

        70         80         90        100        110        120 
ELYNMFPEEK VIGIYRMTSP CLLVRDLEVI KHIMIKDFEV FSDRGLEFSK EGLGQNLFHA 

       130        140        150        160        170        180 
DGDTWRTLRN RFTPIFTSGK LKNMFYLMNE GADNFIDHVS KECEKHQEFE IHTLLQTYTM 

       190        200        210        220        230        240 
STISSCAFGV SYDTISDKLD TLAIVDKIIS EPSYAIELDM MYPGLLPKLN LSIFPSVVHK 

       250        260        270        280        290        300 
FFKNLVNTIV TQRNGKPSGR NDFMDLILEL RQMGEITSNK YGNNMSTLEI TESVMCAQAF 

       310        320        330        340        350        360 
VFYIAGYETS ATTMAYLTYQ LALNPDIQNK LIAEIDEAIK ANGGKVTYDT VKDMKYLNKV 

       370        380        390        400        410        420 
FDETLRMYSI VEPLQRKAIR DYKLPGTDVV IEKDTVVLIS PRGIHYDPKY YDNPKQFNPE 

       430        440        450        460        470        480 
RFFAEEVGKR HPCAYLPFGL GQRNCIGMRF GRLQSLLCIT KLLSKFRLEP SKNTDRNLQV 

       490        500 
EPYRFIIGPK GGIRLNIVPR KDVS 

« Hide

References

[1]"Isolation and sequence analysis of a cDNA clone for a pyrethroid inducible cytochrome P450 from Helicoverpa armigera."
Wang X.P., Hobbs A.A.
Insect Biochem. Mol. Biol. 25:1001-1009(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Midgut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18085 mRNA. Translation: AAB60252.1.

3D structure databases

ProteinModelPortalQ27664.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP6B2_HELAM
AccessionPrimary (citable) accession number: Q27664
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families