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Protein

CTP synthase

Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (GSB_17587), CTP synthase (DHA2_17587), CTP synthase, CTP synthase (DHA2_4507), CTP synthase (GSB_4507)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
UTP--ammonia ligaseUniRule annotation
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Interactioni

Protein-protein interaction databases

STRINGi184922.XP_001709668.1.

Structurei

3D structure databases

ProteinModelPortaliQ27660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini366 – 619Glutamine amidotransferase type-1InterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotation

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 2 hits.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 3 hits.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTYYIFVTG GVISGIGKGL FAASLGMLIK SYGYDVVMQK CDPYINVDPG
60 70 80 90 100
LMSPYQHGEV FVTDDGAETD LDLGHYERFL DTNLTRLSSV TTGSIYSTVI
110 120 130 140 150
QREREGGYNG MTVQVVPQIV DEIKARMRCF ELISTVPGEN SEPQRKHSAP
160 170 180 190 200
LASTQKRFVI IEIGGTVGDM ESTAFLEAMR QLIDDVGRCN ACSFHVSYIP
210 220 230 240 250
VLSNGKELKT KPTQHSVRTL LSVGIKPDFL VCRTDTHLPK ETIAKLAHSC
260 270 280 290 300
GLSKDHVIEN FTVQSIYQLP LLIKHVPALV FNLFNVIPIR ATAEKEAEAS
310 320 330 340 350
LDKWSEIVER FIHPATLSTG DALACKEYDK KSHIRIGLVG KYVELRDAYI
360 370 380 390 400
SVYEAIHHAA AHSNCYVDIL SIVSDTCEGA DRASSSTPAP KAQSAEPAKF
410 420 430 440 450
EEKLHTETSN FVPATVTLEN VDAIIIPGGF GSRGVSGKLE AIKYCRQNNK
460 470 480 490 500
PILGICLGMQ CMAIEFANNV LNLKDATSTE FDPETTNPVI ATIISEDVKA
510 520 530 540 550
ANPLAATLIR GSGGSMRLGA CNCTLLNGTL AQKCYQCKNI RERHRHRYEF
560 570 580 590 600
NGRYKTLFEE AGVVFSGLST ESSLVEIMEI PSLDFFLGVQ FHPELLSRPL
610 620
KPHPLFVGLI GAALAKKRGM
Length:620
Mass (Da):68,022
Last modified:November 1, 1996 - v1
Checksum:i82879BC080AF8854
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30328 Genomic DNA. Translation: AAB41453.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30328 Genomic DNA. Translation: AAB41453.1.

3D structure databases

ProteinModelPortaliQ27660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi184922.XP_001709668.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Family and domain databases

CDDicd01746. GATase1_CTP_Synthase. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 2 hits.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR033828. GATase1_CTP_Synthase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 3 hits.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27660_GIAIN
AccessioniPrimary (citable) accession number: Q27660
Secondary accession number(s): A8B4R0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.