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Q27650 (LYS4_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
Gene names
Name:LYS4
OrganismEntamoeba histolytica
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has antibacterial activity against Gram-positive bacteria. No activity against S.aureus.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Cytoplasmic granule.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Biophysicochemical properties

pH dependence:

Optimally active at acid pH.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Lysozyme
PRO_0000084536

Sites

Active site981 By similarity

Experimental info

Sequence uncertainty171

Sequences

Sequence LengthMass (Da)Tools
Q27650 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 1AF3B73CDAEBBCE9

FASTA19822,379
        10         20         30         40         50         60 
KLGIDVSQPT STSSFTCLRN KGFTTMVIVR AWKSTGSFDT NAPQTLKNAN AAGFSIENSD 

        70         80         90        100        110        120 
VYYYPCISCG NMAGQVRTFW QKVGQYSLKV KRVWFDIEGT WTSSVSTNQN YLMQMMNEAR 

       130        140        150        160        170        180 
AIGIVHGIYG SKYYWGNLFG SSYKYRYRSS TPLWYPHYDN SPSFSDFSSF GGWTSPSMKQ 

       190 
YRGDVSVCSA GVDYNYKP 

« Hide

References

[1]"Purification and molecular cloning of a major antibacterial protein of the protozoan parasite Entamoeba histolytica with lysozyme-like properties."
Jacobs T., Leippe M.
Eur. J. Biochem. 231:831-838(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-198, PROTEIN SEQUENCE OF 1-47; 133-144 AND 180-197.
Strain: ATCC 30459 / HM-1:IMSS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87610 mRNA. Translation: CAA60916.1.
PIRS66599.

3D structure databases

ProteinModelPortalQ27650.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG75899.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS4_ENTHI
AccessionPrimary (citable) accession number: Q27650
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: October 16, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries