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Q27650

- LYS4_ENTHI

UniProt

Q27650 - LYS4_ENTHI

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Protein

Lysozyme

Gene

LYS4

Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has antibacterial activity against Gram-positive bacteria. No activity against S.aureus.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

pH dependencei

Optimally active at acid pH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall macromolecule catabolic process Source: InterPro
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Gene namesi
Name:LYS4
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198LysozymePRO_0000084536Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ27650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Phylogenomic databases

eggNOGiNOG75899.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27650-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KLGIDVSQPT STSSFTCLRN KGFTTMVIVR AWKSTGSFDT NAPQTLKNAN
60 70 80 90 100
AAGFSIENSD VYYYPCISCG NMAGQVRTFW QKVGQYSLKV KRVWFDIEGT
110 120 130 140 150
WTSSVSTNQN YLMQMMNEAR AIGIVHGIYG SKYYWGNLFG SSYKYRYRSS
160 170 180 190
TPLWYPHYDN SPSFSDFSSF GGWTSPSMKQ YRGDVSVCSA GVDYNYKP
Length:198
Mass (Da):22,379
Last modified:November 1, 1998 - v2
Checksum:i1AF3B73CDAEBBCE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi17 – 171

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87610 mRNA. Translation: CAA60916.1.
PIRiS66599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87610 mRNA. Translation: CAA60916.1 .
PIRi S66599.

3D structure databases

ProteinModelPortali Q27650.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG75899.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01183. Glyco_hydro_25. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Purification and molecular cloning of a major antibacterial protein of the protozoan parasite Entamoeba histolytica with lysozyme-like properties."
    Jacobs T., Leippe M.
    Eur. J. Biochem. 231:831-838(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-198, PROTEIN SEQUENCE OF 1-47; 133-144 AND 180-197.
    Strain: ATCC 30459 / HM-1:IMSS.

Entry informationi

Entry nameiLYS4_ENTHI
AccessioniPrimary (citable) accession number: Q27650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3