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Protein

Hexokinase

Gene

HXK1

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKQ27647.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
Gene namesi
Name:HXK1Imported
ORF Names:EHI_098290Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_098290.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4LXB2.

Structurei

3D structure databases

ProteinModelPortaliQ27647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

InParanoidiQ27647.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q27647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEIIDQFAI DKEKMEIIVS KLLEEMENGL QDKPSTLQML PTYAPIPTGK
60 70 80 90 100
EVGTFMGIDV GGTNLRVLLL EIPEPGVRGE LKSVECIMPK TSTTVDQFFG
110 120 130 140 150
FIAQKIKEFV ENNNLKEKEI KAGLTFSFAV EQIAIDKGIQ QSWSKGWDVK
160 170 180 190 200
ESIGKDIVEI FHNQLAKINV NNIRIVAFIN DTVGTFANLA YDDASCGMGL
210 220 230 240 250
IFGTGTNGCY IEKTSNFAAS KLKSVYKEDY MIVNTEWGGL QFPELGLNRF
260 270 280 290 300
DDMINDVSVN KDQQRYEKMI SGIYMGWLAR LAIRELIEKK VIFERYADAE
310 320 330 340 350
VFSNSPDDTQ FNDKKKYSSR HTEIVEDTSP ELSRVDTILK SLGVNDSTLE
360 370 380 390 400
ERKILKAITE AVVKRAAYLS AAATVALYRK MVPYMKERTT AGIDGTVYEK
410 420 430 440
SVPFKRFYLE AIRLLQPKEN FTCQLSKDGS GLGAVIVAAA VACKH
Length:445
Mass (Da):49,830
Last modified:November 1, 1996 - v1
Checksum:iC5B888693A00826D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK418850 mRNA. Translation: BAN37591.1.
X82197 mRNA. Translation: CAA57681.1.
DS571169 Genomic DNA. Translation: EAL48234.1.
RefSeqiXP_653620.1. XM_648528.2.

Genome annotation databases

EnsemblProtistsirna_EHI_098290-1; rna_EHI_098290-1; EHI_098290.
GeneIDi3407925.
KEGGiehi:EHI_098290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK418850 mRNA. Translation: BAN37591.1.
X82197 mRNA. Translation: CAA57681.1.
DS571169 Genomic DNA. Translation: EAL48234.1.
RefSeqiXP_653620.1. XM_648528.2.

3D structure databases

ProteinModelPortaliQ27647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi294381.C4LXB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsirna_EHI_098290-1; rna_EHI_098290-1; EHI_098290.
GeneIDi3407925.
KEGGiehi:EHI_098290.

Organism-specific databases

EuPathDBiAmoebaDB:EHI_098290.

Phylogenomic databases

InParanoidiQ27647.
KOiK00844.

Enzyme and pathway databases

SABIO-RKQ27647.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of two hexokinase isoenzymes, pathogencity markers for the human parasite Entamoeba histolytica."
    Ortner S., Plaimauer B., Binder M., Scheiner O., Wiedermann G., Duchene M.
    Mol. Biochem. Parasitol. 73:189-198(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SFL-3Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  4. "Short 5' UTR of Entamoeba genes."
    Hiranuka K., Kumagai M., Wakaguri H., Suzuki Y., Sugano S., Watanabe J., Makioka A.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HM-1:IMSSImported.

Entry informationi

Entry nameiQ27647_ENTHI
AccessioniPrimary (citable) accession number: Q27647
Secondary accession number(s): C4LXB2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.