Q27647 (Q27647_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hexokinase EMBL CAA57681.1
EC=2.7.1.1 EMBL CAA57681.1

Gene names

Name:	HXK1 EMBL CAA57681.1
ORF Names:	EHI_098290 EMBL EAL48234.1

Organism

Entamoeba histolytica [Reference proteome] EMBL CAA57681.1

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672
Ligand	ATP-binding SAAS SAAS022672 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 EMBL CAA57681.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27647 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C5B888693A00826D	FASTA	445	49,830
	10 20 30 40 50 60 MQEIIDQFAI DKEKMEIIVS KLLEEMENGL QDKPSTLQML PTYAPIPTGK EVGTFMGIDV 70 80 90 100 110 120 GGTNLRVLLL EIPEPGVRGE LKSVECIMPK TSTTVDQFFG FIAQKIKEFV ENNNLKEKEI 130 140 150 160 170 180 KAGLTFSFAV EQIAIDKGIQ QSWSKGWDVK ESIGKDIVEI FHNQLAKINV NNIRIVAFIN 190 200 210 220 230 240 DTVGTFANLA YDDASCGMGL IFGTGTNGCY IEKTSNFAAS KLKSVYKEDY MIVNTEWGGL 250 260 270 280 290 300 QFPELGLNRF DDMINDVSVN KDQQRYEKMI SGIYMGWLAR LAIRELIEKK VIFERYADAE 310 320 330 340 350 360 VFSNSPDDTQ FNDKKKYSSR HTEIVEDTSP ELSRVDTILK SLGVNDSTLE ERKILKAITE 370 380 390 400 410 420 AVVKRAAYLS AAATVALYRK MVPYMKERTT AGIDGTVYEK SVPFKRFYLE AIRLLQPKEN 430 440 FTCQLSKDGS GLGAVIVAAA VACKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of two hexokinase isoenzymes, pathogencity markers for the human parasite Entamoeba histolytica." Ortner S., Plaimauer B., Binder M., Scheiner O., Wiedermann G., Duchene M. Mol. Biochem. Parasitol. 73:189-198(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SFL-3 EMBL CAA57681.1.
[2]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[3]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82197 mRNA. Translation: CAA57681.1. DS571169 Genomic DNA. Translation: EAL48234.1.
RefSeq	XP_653620.1. XM_648528.2.
3D structure databases
HSSP	HSSP built from PDB template 1BDG based on UniProtKB Q26609.
ModBase	Search...
Protein-protein interaction databases
STRING	294381.C4LXB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	rna_EHI_098290-1; rna_EHI_098290-1; EHI_098290.
GeneID	3407925.
KEGG	ehi:EHI_098290.
Organism-specific databases
EuPathDB	AmoebaDB:EHI_098290.
Phylogenomic databases
KO	K00844.
ProtClustDB	CLSZ2731647.
Enzyme and pathway databases
SABIO-RK	Q27647.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
ProtoNet	Search...

Entry information

Entry name

Q27647_ENTHI

Accession

Primary (citable) accession number: Q27647
Secondary accession number(s): C4LXB2

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)