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Protein
Submitted name:

Cysteine proteinase

Gene
N/A
Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Protein family/group databases

MEROPSiC01.155.

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine proteinaseImported (EC:3.4.22.35Imported)
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020UniRule annotationAdd
BLAST
Chaini21 – 311291UniRule annotationPRO_5005400178Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5759.rna_EHI_050570-1.

Structurei

3D structure databases

ProteinModelPortaliQ27643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 7156Inhibitor_I29InterPro annotationAdd
BLAST
Domaini94 – 305212Pept_C1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNFLLLVVA ASAIDFKSWA AKNNKHFTAV EALRRRAIFN MNAKFEAKFN
60 70 80 90 100
KEHSFELTVE GPFAAMTNQE YNNLLKTHET EAAADSVYDN TIITATTKDW
110 120 130 140 150
RAEGKVTPVR DQGNCGSCYS FSSLAVLESR LLIAGSKYNQ NNLDLSEQQI
160 170 180 190 200
VDCSAANNGC NGGSLSATYL YVKNKGVTDE ASYPYTATKG TCKAFTPKVQ
210 220 230 240 250
TTGLTHVTPT EEALTAALAE GPVAVCIDAG KASFQLYKNG VYDEPKCSKT
260 270 280 290 300
VNHGVAAVGY GSQDGQDYYI VKNSWGTSWG DKGYILMSRN KNNQCAIASV
310
AYFPTGAHDA N
Length:311
Mass (Da):33,745
Last modified:November 1, 1996 - v1
Checksum:iA7C17A37E2E7BB9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91642 Genomic DNA. Translation: CAA62833.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91642 Genomic DNA. Translation: CAA62833.1.

3D structure databases

ProteinModelPortaliQ27643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_050570-1.

Protein family/group databases

MEROPSiC01.155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27643_ENTHI
AccessioniPrimary (citable) accession number: Q27643
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.