Q27642 (Q27642_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Putative plasma membrane calcium ion-transporting ATPase EMBL AAC28745.1
Organism	Entamoeba histolytica EMBL AAC28745.1
Taxonomic identifier	5759 [NCBI]
Taxonomic lineage	Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	1086 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS004014
Ligand	ATP-binding SAAS SAAS004014 RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS004014 RuleBase RU000653
PTM	Phosphoprotein RuleBase RU000653 SAAS SAAS004014
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27642 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: D5A340846A408E0C	FASTA	1,086	121,003
	10 20 30 40 50 60 MGGKPSKQEE QKKEYTGQPE GTPYYDIQGC ELAKMVSTNN KEIYDKYGGV IGISKILEVD 70 80 90 100 110 120 LDKGICDESY SKRQEQFGKN RTPDAVIVPF WKIWFEALQD KTLIILIIAA IVSLILAFAV 130 140 150 160 170 180 PNSVDKCLAK ENEEDKELNT DWIEGVAILI AVLAVSLGGS ASDYSKQKKF LALSQEEKDV 190 200 210 220 230 240 GIKVIRNGEN QKTSIFNLSV GDIVNLDVGD IIPADGIYIH GNDLRVDQAS MTGESVAVRK 250 260 270 280 290 300 TSENFSMMSG TKVMDGNGKM LVVAVGPNSL WGKTMEAVNQ NKSAPTPLQE NLDELAVKIG 310 320 330 340 350 360 YLGMGCGALV FIVLTIYYIV SQFTHKDVLK ADEEKGIIAG CLECNVTRED VMWNEYCEKY 370 380 390 400 410 420 SFDWSSLTGL IDYFIIGVTI IVVAVPEGLP LAVTISLAYS MKQMFKDNNL VRHLKVCETM 430 440 450 460 470 480 SNCTNICSDK TGTLTENRMT VVNGWFGGIK METRDQKFQF LKNMKKLINM NISINSSPST 490 500 510 520 530 540 TLISENGQIN VIGNKTEGAL LMYVKERGVD YLEIRKRNEN NIYQMFAFSS AKKRMNTLVW 550 560 570 580 590 600 IDKPNTIRMF TKGAPEMILE KCQYYMNGQG EIKEITEEVR QELEECQVEW ASKGYRTLSL 610 620 630 640 650 660 SYKDITPANR NNLEEKYEVA NEEGSIIISL FGIEDPVRRE VPGAVATCQR AGIIVRMVRG 670 680 690 700 710 720 DNIATARSIA KQCNIISREN DIAIEGPKFA ELTDEEIIEK LENLRVIARC SPQDKERLVK 730 740 750 760 770 780 LLISQGEVVA VTGDGTNDVP ALKAADVGLA MGIRGTDVAK QASDIVILDD NFQSIVNSVN 790 800 810 820 830 840 GERCVYDNIR KFLQFQLTVN ISALALCVIG SIFIGESPLN ALQMLWVNLI MDTMAALALG 850 860 870 880 890 900 TEKTNRFIID RKPFGRFDSL ISNIMIRNII VQTVYQLELC YQLFLQKYIP FLNSPCGFVK 910 920 930 940 950 960 TVGHSGGEDF SKYCAGDNIG FKSINDVKND TIELQTLVFN IFVFCQVFNE FNSRKVNGEH 970 980 990 1000 1010 1020 NVFSNLFTNF IFLTIIGVTI IIQTIIVQFL GILFDGVPFI PSQGQYGLSW QGWVLSLLLS 1030 1040 1050 1060 1070 1080 CMTLVIGQIS FFIPVPTSKP KKFKNQPSLL TKILCCGFCN KKDVKSSSSE SSDDDDNLEK KSLLSN

References

[1]	"Vacuolar localization of an Entamoeba histolytica homologue of the plasma membrane ATPase (PMCA)." Ghosh S.K., Rosenthal B., Rogers R., Samuelson J. Mol. Biochem. Parasitol. 108:125-130(2000) [PubMed: 10802325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: HM-1:IMSS EMBL AAC28745.1.
[2]	"Primary structure of a putative plasma membrane calcium ion-transporting ATPase." Shen P., Yu Y., Samuelson J.C. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: HM-1:IMSS EMBL AAC28745.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20321 mRNA. Translation: AAC28745.1.
PIR	T18294.
3D structure databases
HSSP	HSSP built from PDB template 1SU4 based on UniProtKB P04191.
ProteinModelPortal	Q27642.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27642_ENTHI

Accession

Primary (citable) accession number: Q27642

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	May 1, 1999
Last modified:	June 28, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)