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Q27640

- ALDH_ENCBU

UniProt

Q27640 - ALDH_ENCBU

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Protein
Aldehyde dehydrogenase
Gene
ALDH
Organism
Enchytraeus buchholzi (Grindal worm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Could be indirectly involved in cadmium-detoxification, by lowering the intracellular concentrations of aldehydes.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei167 – 1671Transition state stabilizer By similarity
Active sitei266 – 2661Proton acceptor By similarity
Active sitei300 – 3001Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2486NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase [NAD(+)]
Gene namesi
Name:ALDH
OrganismiEnchytraeus buchholzi (Grindal worm)
Taxonomic identifieri34589 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaTubificinaEnchytraeidaeEnchytraeus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Aldehyde dehydrogenase
PRO_0000056430Add
BLAST

Proteomic databases

PRIDEiQ27640.

Expressioni

Inductioni

By cadmium.

Structurei

3D structure databases

ProteinModelPortaliQ27640.
SMRiQ27640. Positions 6-496.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27640-1 [UniParc]FASTAAdd to Basket

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MSAPKIPEPV KDLKVEFTKI FINNEFVDSV SGKTFATINP STGEKLAEVQ    50
EGDKADIDKA VAAARAAFKR DAEYRKHDAS DRGRLLFKLA DLIEAHRVQL 100
RTLETLDNGK PFAMSYLGDT LMAQKVLRYY AGFADKIVGQ TIPADGNVFC 150
YTRHEPVGVV GAITPWNFPL HLAASKIAPA IAAGCTLVLK PAEQTPLTAL 200
YLASLVKQAG FPAGVINIVP GLGHTAGAAL TNHPDINKIT FTGSTEVGQL 250
IIQGSGKTNL KRVTLELGGK SPNIIFPDSD LDYAVEVSHQ AIMANMGQVC 300
CAGSRTFVHE DIYEEFVRRS VERAKKRTVG DPFDPKNENG PQVDETQLKK 350
ILELIESGKT EGAKLECGGK RLGDKGYFVE PTVFTDVTSS MRVAKEEIFG 400
PVQLIFKFKD VDEVIERAND TSYGLAAAVF TKNIDTALKV ANSLEAGTVW 450
VNTYNHFAFQ APFGGYKMSG QGREFGHYGL EAFLEVKTVY VRTPTKL 497
Length:497
Mass (Da):54,159
Last modified:November 1, 1996 - v1
Checksum:iA35A562876808BCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95396 mRNA. Translation: CAA64680.1.
PIRiJC4924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95396 mRNA. Translation: CAA64680.1 .
PIRi JC4924.

3D structure databases

ProteinModelPortali Q27640.
SMRi Q27640. Positions 6-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q27640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cadmium-detoxification in the earthworm Enchytraeus: specific expression of a putative aldehyde dehydrogenase."
    Willuhn J., Schmitt-Wrede H.-P., Otto A., Wunderlich F.
    Biochem. Biophys. Res. Commun. 226:128-134(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALDH_ENCBU
AccessioniPrimary (citable) accession number: Q27640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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