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Q27640

- ALDH_ENCBU

UniProt

Q27640 - ALDH_ENCBU

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Protein

Aldehyde dehydrogenase

Gene

ALDH

Organism
Enchytraeus buchholzi (Grindal worm)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could be indirectly involved in cadmium-detoxification, by lowering the intracellular concentrations of aldehydes.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei167 – 1671Transition state stabilizerBy similarity
Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation
Active sitei300 – 3001NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2486NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase [NAD(+)]
Gene namesi
Name:ALDH
OrganismiEnchytraeus buchholzi (Grindal worm)
Taxonomic identifieri34589 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaTubificinaEnchytraeidaeEnchytraeus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056430Add
BLAST

Proteomic databases

PRIDEiQ27640.

Expressioni

Inductioni

By cadmium.

Structurei

3D structure databases

ProteinModelPortaliQ27640.
SMRiQ27640. Positions 6-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPKIPEPV KDLKVEFTKI FINNEFVDSV SGKTFATINP STGEKLAEVQ
60 70 80 90 100
EGDKADIDKA VAAARAAFKR DAEYRKHDAS DRGRLLFKLA DLIEAHRVQL
110 120 130 140 150
RTLETLDNGK PFAMSYLGDT LMAQKVLRYY AGFADKIVGQ TIPADGNVFC
160 170 180 190 200
YTRHEPVGVV GAITPWNFPL HLAASKIAPA IAAGCTLVLK PAEQTPLTAL
210 220 230 240 250
YLASLVKQAG FPAGVINIVP GLGHTAGAAL TNHPDINKIT FTGSTEVGQL
260 270 280 290 300
IIQGSGKTNL KRVTLELGGK SPNIIFPDSD LDYAVEVSHQ AIMANMGQVC
310 320 330 340 350
CAGSRTFVHE DIYEEFVRRS VERAKKRTVG DPFDPKNENG PQVDETQLKK
360 370 380 390 400
ILELIESGKT EGAKLECGGK RLGDKGYFVE PTVFTDVTSS MRVAKEEIFG
410 420 430 440 450
PVQLIFKFKD VDEVIERAND TSYGLAAAVF TKNIDTALKV ANSLEAGTVW
460 470 480 490
VNTYNHFAFQ APFGGYKMSG QGREFGHYGL EAFLEVKTVY VRTPTKL
Length:497
Mass (Da):54,159
Last modified:November 1, 1996 - v1
Checksum:iA35A562876808BCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95396 mRNA. Translation: CAA64680.1.
PIRiJC4924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95396 mRNA. Translation: CAA64680.1 .
PIRi JC4924.

3D structure databases

ProteinModelPortali Q27640.
SMRi Q27640. Positions 6-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q27640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cadmium-detoxification in the earthworm Enchytraeus: specific expression of a putative aldehyde dehydrogenase."
    Willuhn J., Schmitt-Wrede H.-P., Otto A., Wunderlich F.
    Biochem. Biophys. Res. Commun. 226:128-134(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALDH_ENCBU
AccessioniPrimary (citable) accession number: Q27640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3