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Q27640

- ALDH_ENCBU

UniProt

Q27640 - ALDH_ENCBU

Protein

Aldehyde dehydrogenase

Gene

ALDH

Organism
Enchytraeus buchholzi (Grindal worm)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Could be indirectly involved in cadmium-detoxification, by lowering the intracellular concentrations of aldehydes.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei167 – 1671Transition state stabilizerBy similarity
    Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation
    Active sitei300 – 3001NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi243 – 2486NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase [NAD(+)]
    Gene namesi
    Name:ALDH
    OrganismiEnchytraeus buchholzi (Grindal worm)
    Taxonomic identifieri34589 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaTubificinaEnchytraeidaeEnchytraeus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Aldehyde dehydrogenasePRO_0000056430Add
    BLAST

    Proteomic databases

    PRIDEiQ27640.

    Expressioni

    Inductioni

    By cadmium.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27640.
    SMRiQ27640. Positions 6-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27640-1 [UniParc]FASTAAdd to Basket

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    MSAPKIPEPV KDLKVEFTKI FINNEFVDSV SGKTFATINP STGEKLAEVQ    50
    EGDKADIDKA VAAARAAFKR DAEYRKHDAS DRGRLLFKLA DLIEAHRVQL 100
    RTLETLDNGK PFAMSYLGDT LMAQKVLRYY AGFADKIVGQ TIPADGNVFC 150
    YTRHEPVGVV GAITPWNFPL HLAASKIAPA IAAGCTLVLK PAEQTPLTAL 200
    YLASLVKQAG FPAGVINIVP GLGHTAGAAL TNHPDINKIT FTGSTEVGQL 250
    IIQGSGKTNL KRVTLELGGK SPNIIFPDSD LDYAVEVSHQ AIMANMGQVC 300
    CAGSRTFVHE DIYEEFVRRS VERAKKRTVG DPFDPKNENG PQVDETQLKK 350
    ILELIESGKT EGAKLECGGK RLGDKGYFVE PTVFTDVTSS MRVAKEEIFG 400
    PVQLIFKFKD VDEVIERAND TSYGLAAAVF TKNIDTALKV ANSLEAGTVW 450
    VNTYNHFAFQ APFGGYKMSG QGREFGHYGL EAFLEVKTVY VRTPTKL 497
    Length:497
    Mass (Da):54,159
    Last modified:November 1, 1996 - v1
    Checksum:iA35A562876808BCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95396 mRNA. Translation: CAA64680.1.
    PIRiJC4924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95396 mRNA. Translation: CAA64680.1 .
    PIRi JC4924.

    3D structure databases

    ProteinModelPortali Q27640.
    SMRi Q27640. Positions 6-496.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q27640.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cadmium-detoxification in the earthworm Enchytraeus: specific expression of a putative aldehyde dehydrogenase."
      Willuhn J., Schmitt-Wrede H.-P., Otto A., Wunderlich F.
      Biochem. Biophys. Res. Commun. 226:128-134(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiALDH_ENCBU
    AccessioniPrimary (citable) accession number: Q27640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3