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Q27640 (ALDH_ENCBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase
EC=1.2.1.3
Alternative name(s):
Aldehyde dehydrogenase [NAD(+)]
Gene names
Name:ALDH
OrganismEnchytraeus buchholzi (Grindal worm)
Taxonomic identifier34589 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Lophotrochozoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Tubificina › Enchytraeidae › Enchytraeus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be indirectly involved in cadmium-detoxification, by lowering the intracellular concentrations of aldehydes.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Induction

By cadmium.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Aldehyde dehydrogenase
PRO_0000056430

Regions

Nucleotide binding243 – 2486NAD By similarity

Sites

Active site2661Proton acceptor By similarity
Active site3001Nucleophile By similarity
Site1671Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27640 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A35A562876808BCC

FASTA49754,159
        10         20         30         40         50         60 
MSAPKIPEPV KDLKVEFTKI FINNEFVDSV SGKTFATINP STGEKLAEVQ EGDKADIDKA 

        70         80         90        100        110        120 
VAAARAAFKR DAEYRKHDAS DRGRLLFKLA DLIEAHRVQL RTLETLDNGK PFAMSYLGDT 

       130        140        150        160        170        180 
LMAQKVLRYY AGFADKIVGQ TIPADGNVFC YTRHEPVGVV GAITPWNFPL HLAASKIAPA 

       190        200        210        220        230        240 
IAAGCTLVLK PAEQTPLTAL YLASLVKQAG FPAGVINIVP GLGHTAGAAL TNHPDINKIT 

       250        260        270        280        290        300 
FTGSTEVGQL IIQGSGKTNL KRVTLELGGK SPNIIFPDSD LDYAVEVSHQ AIMANMGQVC 

       310        320        330        340        350        360 
CAGSRTFVHE DIYEEFVRRS VERAKKRTVG DPFDPKNENG PQVDETQLKK ILELIESGKT 

       370        380        390        400        410        420 
EGAKLECGGK RLGDKGYFVE PTVFTDVTSS MRVAKEEIFG PVQLIFKFKD VDEVIERAND 

       430        440        450        460        470        480 
TSYGLAAAVF TKNIDTALKV ANSLEAGTVW VNTYNHFAFQ APFGGYKMSG QGREFGHYGL 

       490 
EAFLEVKTVY VRTPTKL

« Hide

References

[1]"Cadmium-detoxification in the earthworm Enchytraeus: specific expression of a putative aldehyde dehydrogenase."
Willuhn J., Schmitt-Wrede H.-P., Otto A., Wunderlich F.
Biochem. Biophys. Res. Commun. 226:128-134(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95396 mRNA. Translation: CAA64680.1.
PIRJC4924.

3D structure databases

ProteinModelPortalQ27640.
SMRQ27640. Positions 6-496.
ModBaseSearch...

Proteomic databases

PRIDEQ27640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_ENCBU
AccessionPrimary (citable) accession number: Q27640
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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