Reviewed, UniProtKB/Swiss-Prot Q27640 (ALDH_ENCBU)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase
    EC=1.2.1.3
Alternative name(s):
    Aldehyde dehydrogenase [NAD+]

Gene names

Name:

ALDH

Organism

Enchytraeus buchholzi

Taxonomic identifier

34589 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Tubificina › Enchytraeidae › Enchytraeus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Could be indirectly involved in cadmium-detoxification, by lowering the intracellular concentrations of aldehydes.
Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Induction	By cadmium.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Aldehyde dehydrogenase		PRO_0000056430
Regions
	Nucleotide binding	243 – 248	6	NAD By similarity
Sites
	Active site	266	1	Proton acceptor By similarity
	Active site	300	1	Nucleophile By similarity
	Site	167	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27640-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A35A562876808BCC	FASTA	497	54,159
	10 20 30 40 50 60 MSAPKIPEPV KDLKVEFTKI FINNEFVDSV SGKTFATINP STGEKLAEVQ EGDKADIDKA 70 80 90 100 110 120 VAAARAAFKR DAEYRKHDAS DRGRLLFKLA DLIEAHRVQL RTLETLDNGK PFAMSYLGDT 130 140 150 160 170 180 LMAQKVLRYY AGFADKIVGQ TIPADGNVFC YTRHEPVGVV GAITPWNFPL HLAASKIAPA 190 200 210 220 230 240 IAAGCTLVLK PAEQTPLTAL YLASLVKQAG FPAGVINIVP GLGHTAGAAL TNHPDINKIT 250 260 270 280 290 300 FTGSTEVGQL IIQGSGKTNL KRVTLELGGK SPNIIFPDSD LDYAVEVSHQ AIMANMGQVC 310 320 330 340 350 360 CAGSRTFVHE DIYEEFVRRS VERAKKRTVG DPFDPKNENG PQVDETQLKK ILELIESGKT 370 380 390 400 410 420 EGAKLECGGK RLGDKGYFVE PTVFTDVTSS MRVAKEEIFG PVQLIFKFKD VDEVIERAND 430 440 450 460 470 480 TSYGLAAAVF TKNIDTALKV ANSLEAGTVW VNTYNHFAFQ APFGGYKMSG QGREFGHYGL 490 EAFLEVKTVY VRTPTKL

References

[1]	"Cadmium-detoxification in the earthworm Enchytraeus: specific expression of a putative aldehyde dehydrogenase." Willuhn J., Schmitt-Wrede H.-P., Otto A., Wunderlich F. Biochem. Biophys. Res. Commun. 226:128-134(1996) [PubMed: 8806602] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X95396 mRNA. Translation: CAA64680.1.
PIR	JC4924.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 301197.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_ENCBU

Accession

Primary (citable) accession number: Q27640

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)