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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

Zw

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Dyak\GE22705), Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Dyak\GE19513)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70NADP 1By similarity1
Binding sitei169NADP 1; via carbonyl oxygenBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei237SubstrateBy similarity1
Binding sitei256SubstrateBy similarity1
Active sitei261Proton acceptorBy similarity1
Binding sitei356NADP 2By similarity1
Binding sitei359SubstrateBy similarity1
Binding sitei364SubstrateBy similarity1
Binding sitei365NADP 2By similarity1
Binding sitei369NADP 2By similarity1
Binding sitei392NADP 2By similarity1
Binding sitei394SubstrateBy similarity1
Binding sitei486NADP 2By similarity1
Binding sitei502NADP 2By similarity1
Binding sitei508NADP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43NADP 1By similarity8
Nucleotide bindingi400 – 402NADP 2By similarity3
Nucleotide bindingi420 – 422NADP 2By similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:Zw
Synonyms:G6pd
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015691. Dyak\Zw.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000068094‹1 – 518Glucose-6-phosphate 1-dehydrogenaseAdd BLAST›518

Proteomic databases

PRIDEiQ27638.

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0260874.

Structurei

3D structure databases

ProteinModelPortaliQ27638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 203Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
OrthoDBiEOG091G06FN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q27638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DHTALDLIIK SLKSPTMVCE GTHFDGKIPH TFVIFGASGD LAKKKIYPKL
60 70 80 90 100
WWFYRDDLLP KLTKFCGYAR SMLTVDSIKE QCLPYMKVQS HEQKKYEEFW
110 120 130 140 150
ALNEYVSGRY DGRTGFELLN QQLELMENKN KANRIFYLAL PPSVFEEVTV
160 170 180 190 200
NIKQICMSVC GWNRVIIEKP FGRDDASSQA LSDHLAALFH EDQLYRIDHY
210 220 230 240 250
LGKEMVQNLM TIRFGNKILS STWNRENIAS VLITFKEPFG TQGRGGYFDE
260 270 280 290 300
FGIIRDVMQN HLLQILSLVA MEKPVSCHPD DIRDEKVKVL KSIETLTLKD
310 320 330 340 350
MVLGQYLGNP QGTTDDARTG YVEDPTVSDD SNTPTYALGV LKINNERWQG
360 370 380 390 400
VPFILRCGKR LNERKAEVRI QYQDVPGDIF EGNTKRNELV IRVQPGEALY
410 420 430 440 450
FKMMTKSPGI TFDIEETELD LTYEHRYKDS YLPDAYERLI LDVFCGSQMH
460 470 480 490 500
FVRSDQLREA WRIFTPILHQ IEREHIRPIT YQYGSRGPKE ADRMCEENNF
510
KYSGSYKWHG GKAATSNL
Length:518
Mass (Da):59,938
Last modified:November 1, 1996 - v1
Checksum:i6AFA194E1D3A3E8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42750 Genomic DNA. Translation: AAB02813.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42750 Genomic DNA. Translation: AAB02813.1.

3D structure databases

ProteinModelPortaliQ27638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0260874.

Proteomic databases

PRIDEiQ27638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0015691. Dyak\Zw.

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
OrthoDBiEOG091G06FN.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD_DROYA
AccessioniPrimary (citable) accession number: Q27638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.