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Q27638

- G6PD_DROYA

UniProt

Q27638 - G6PD_DROYA

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

Zw

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701NADP 1By similarity
    Binding sitei169 – 1691NADP 1; via carbonyl oxygenBy similarity
    Binding sitei169 – 1691SubstrateBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Binding sitei256 – 2561SubstrateBy similarity
    Active sitei261 – 2611Proton acceptorBy similarity
    Binding sitei356 – 3561NADP 2By similarity
    Binding sitei359 – 3591SubstrateBy similarity
    Binding sitei364 – 3641SubstrateBy similarity
    Binding sitei365 – 3651NADP 2By similarity
    Binding sitei369 – 3691NADP 2By similarity
    Binding sitei392 – 3921NADP 2By similarity
    Binding sitei394 – 3941SubstrateBy similarity
    Binding sitei486 – 4861NADP 2By similarity
    Binding sitei502 – 5021NADP 2By similarity
    Binding sitei508 – 5081NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 438NADP 1By similarity
    Nucleotide bindingi400 – 4023NADP 2By similarity
    Nucleotide bindingi420 – 4223NADP 2By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:Zw
    Synonyms:G6pd
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0015691. Dyak\Zw.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 518›518Glucose-6-phosphate 1-dehydrogenasePRO_0000068094Add
    BLAST

    Proteomic databases

    PRIDEiQ27638.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27638.
    SMRiQ27638. Positions 30-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 2035Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    OrthoDBiEOG7DRJ2T.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q27638-1 [UniParc]FASTAAdd to Basket

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    DHTALDLIIK SLKSPTMVCE GTHFDGKIPH TFVIFGASGD LAKKKIYPKL    50
    WWFYRDDLLP KLTKFCGYAR SMLTVDSIKE QCLPYMKVQS HEQKKYEEFW 100
    ALNEYVSGRY DGRTGFELLN QQLELMENKN KANRIFYLAL PPSVFEEVTV 150
    NIKQICMSVC GWNRVIIEKP FGRDDASSQA LSDHLAALFH EDQLYRIDHY 200
    LGKEMVQNLM TIRFGNKILS STWNRENIAS VLITFKEPFG TQGRGGYFDE 250
    FGIIRDVMQN HLLQILSLVA MEKPVSCHPD DIRDEKVKVL KSIETLTLKD 300
    MVLGQYLGNP QGTTDDARTG YVEDPTVSDD SNTPTYALGV LKINNERWQG 350
    VPFILRCGKR LNERKAEVRI QYQDVPGDIF EGNTKRNELV IRVQPGEALY 400
    FKMMTKSPGI TFDIEETELD LTYEHRYKDS YLPDAYERLI LDVFCGSQMH 450
    FVRSDQLREA WRIFTPILHQ IEREHIRPIT YQYGSRGPKE ADRMCEENNF 500
    KYSGSYKWHG GKAATSNL 518
    Length:518
    Mass (Da):59,938
    Last modified:November 1, 1996 - v1
    Checksum:i6AFA194E1D3A3E8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U42750 Genomic DNA. Translation: AAB02813.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U42750 Genomic DNA. Translation: AAB02813.1 .

    3D structure databases

    ProteinModelPortali Q27638.
    SMRi Q27638. Positions 30-508.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q27638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0015691. Dyak\Zw.

    Phylogenomic databases

    eggNOGi COG0364.
    OrthoDBi EOG7DRJ2T.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Eanes W.F., Kirchner M., Yoon J., Biermann C., Wang I., McCartney M., Verrelli B.C.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BG1016.

    Entry informationi

    Entry nameiG6PD_DROYA
    AccessioniPrimary (citable) accession number: Q27638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3