Reviewed, UniProtKB/Swiss-Prot Q27638 (G6PD_DROYA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	Zw
Synonyms:	G6pd

Organism

Drosophila yakuba (Fruit fly)

Taxonomic identifier

7245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	518 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 518	›518	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068094
Sites
	Active site	261	1	Proton acceptor By similarity
	Binding site	38	1	NADP By similarity
	Binding site	70	1	NADP By similarity
	Binding site	199	1	Substrate By similarity
	Binding site	203	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q27638-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6AFA194E1D3A3E8B	FASTA	518	59,938
	10 20 30 40 50 60 DHTALDLIIK SLKSPTMVCE GTHFDGKIPH TFVIFGASGD LAKKKIYPKL WWFYRDDLLP 70 80 90 100 110 120 KLTKFCGYAR SMLTVDSIKE QCLPYMKVQS HEQKKYEEFW ALNEYVSGRY DGRTGFELLN 130 140 150 160 170 180 QQLELMENKN KANRIFYLAL PPSVFEEVTV NIKQICMSVC GWNRVIIEKP FGRDDASSQA 190 200 210 220 230 240 LSDHLAALFH EDQLYRIDHY LGKEMVQNLM TIRFGNKILS STWNRENIAS VLITFKEPFG 250 260 270 280 290 300 TQGRGGYFDE FGIIRDVMQN HLLQILSLVA MEKPVSCHPD DIRDEKVKVL KSIETLTLKD 310 320 330 340 350 360 MVLGQYLGNP QGTTDDARTG YVEDPTVSDD SNTPTYALGV LKINNERWQG VPFILRCGKR 370 380 390 400 410 420 LNERKAEVRI QYQDVPGDIF EGNTKRNELV IRVQPGEALY FKMMTKSPGI TFDIEETELD 430 440 450 460 470 480 LTYEHRYKDS YLPDAYERLI LDVFCGSQMH FVRSDQLREA WRIFTPILHQ IEREHIRPIT 490 500 510 YQYGSRGPKE ADRMCEENNF KYSGSYKWHG GKAATSNL

References

[1]	Eanes W.F., Kirchner M., Yoon J., Biermann C., Wang I., McCartney M., Verrelli B.C. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BG1016.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U42750 Genomic DNA. Translation: AAB02813.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0015691. Dyak\Zw.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_DROYA

Accession

Primary (citable) accession number: Q27638

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project