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Q27638

- G6PD_DROYA

UniProt

Q27638 - G6PD_DROYA

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
Zw, G6pd
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701NADP 1 By similarity
Binding sitei169 – 1691NADP 1; via carbonyl oxygen By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Binding sitei256 – 2561Substrate By similarity
Active sitei261 – 2611Proton acceptor By similarity
Binding sitei356 – 3561NADP 2 By similarity
Binding sitei359 – 3591Substrate By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei365 – 3651NADP 2 By similarity
Binding sitei369 – 3691NADP 2 By similarity
Binding sitei392 – 3921NADP 2 By similarity
Binding sitei394 – 3941Substrate By similarity
Binding sitei486 – 4861NADP 2 By similarity
Binding sitei502 – 5021NADP 2 By similarity
Binding sitei508 – 5081NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438NADP 1 By similarity
Nucleotide bindingi400 – 4023NADP 2 By similarity
Nucleotide bindingi420 – 4223NADP 2 By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. NADP metabolic process Source: UniProtKB
  2. glucose 6-phosphate metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:Zw
Synonyms:G6pd
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015691. Dyak\Zw.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 518›518Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068094Add
BLAST

Proteomic databases

PRIDEiQ27638.

Structurei

3D structure databases

ProteinModelPortaliQ27638.
SMRiQ27638. Positions 30-508.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2035Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
OrthoDBiEOG7DRJ2T.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q27638-1 [UniParc]FASTAAdd to Basket

« Hide

DHTALDLIIK SLKSPTMVCE GTHFDGKIPH TFVIFGASGD LAKKKIYPKL    50
WWFYRDDLLP KLTKFCGYAR SMLTVDSIKE QCLPYMKVQS HEQKKYEEFW 100
ALNEYVSGRY DGRTGFELLN QQLELMENKN KANRIFYLAL PPSVFEEVTV 150
NIKQICMSVC GWNRVIIEKP FGRDDASSQA LSDHLAALFH EDQLYRIDHY 200
LGKEMVQNLM TIRFGNKILS STWNRENIAS VLITFKEPFG TQGRGGYFDE 250
FGIIRDVMQN HLLQILSLVA MEKPVSCHPD DIRDEKVKVL KSIETLTLKD 300
MVLGQYLGNP QGTTDDARTG YVEDPTVSDD SNTPTYALGV LKINNERWQG 350
VPFILRCGKR LNERKAEVRI QYQDVPGDIF EGNTKRNELV IRVQPGEALY 400
FKMMTKSPGI TFDIEETELD LTYEHRYKDS YLPDAYERLI LDVFCGSQMH 450
FVRSDQLREA WRIFTPILHQ IEREHIRPIT YQYGSRGPKE ADRMCEENNF 500
KYSGSYKWHG GKAATSNL 518
Length:518
Mass (Da):59,938
Last modified:November 1, 1996 - v1
Checksum:i6AFA194E1D3A3E8B
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U42750 Genomic DNA. Translation: AAB02813.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U42750 Genomic DNA. Translation: AAB02813.1 .

3D structure databases

ProteinModelPortali Q27638.
SMRi Q27638. Positions 30-508.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q27638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0015691. Dyak\Zw.

Phylogenomic databases

eggNOGi COG0364.
OrthoDBi EOG7DRJ2T.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Eanes W.F., Kirchner M., Yoon J., Biermann C., Wang I., McCartney M., Verrelli B.C.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BG1016.

Entry informationi

Entry nameiG6PD_DROYA
AccessioniPrimary (citable) accession number: Q27638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi