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Protein

Cytochrome P450 6a9

Gene

Cyp6a9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi449Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-211958 Miscellaneous substrates
R-DME-211979 Eicosanoids
R-DME-211981 Xenobiotics
R-DME-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-DME-5423646 Aflatoxin activation and detoxification
R-DME-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6a9 (EC:1.14.-.-)
Alternative name(s):
CYPVIA9
Gene namesi
Name:Cyp6a9
ORF Names:CG10246
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013771 Cyp6a9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518681 – 504Cytochrome P450 6a9Add BLAST504

Proteomic databases

PaxDbiQ27594
PRIDEiQ27594

Expressioni

Gene expression databases

BgeeiFBgn0013771
GenevisibleiQ27594 DM

Interactioni

Protein-protein interaction databases

BioGridi62405, 6 interactors
IntActiQ27594, 5 interactors
STRINGi7227.FBpp0289405

Structurei

3D structure databases

ProteinModelPortaliQ27594
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
InParanoidiQ27594
KOiK14999
OrthoDBiEOG091G0JNC
PhylomeDBiQ27594

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q27594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYSVLLAI VVVLVGYLLL KWRRALHYWQ NLDIPCEEPH ILMGSLTGVQ
60 70 80 90 100
TSRSFSAIWM DYYNKFRGTG PFAGFYWFQR PGILVLDISL AKLILIKEFN
110 120 130 140 150
KFTDRGFYHN TEDDPLSGQL FLLDGQKWKS MRSKLSYTFT SGKMKYMFPT
160 170 180 190 200
VVKVGHEFIE VFGQAMEKSP IVEVRDILAR FTTDVIGTCA FGIECSSLKD
210 220 230 240 250
PEAEFRVMGR RAIFEQRHGP IGIAFINSFQ NLARRLHMKI TLEEAEHFFL
260 270 280 290 300
RIVRETVAFR EKNNIRRNDF MDQLIDLKNS PLTKSESGES VNLTIEEMAA
310 320 330 340 350
QAFVFFGAGF ETSSTTMGFA LYELAQHQDI QDRVRKECQE VIGKYNGEIT
360 370 380 390 400
YESMKDMVYL DQVISETLRL YTVLPVLNRE CLEDYEVPGH PKYVIKKGMP
410 420 430 440 450
VLIPCGAMHR DEKLYANPNT FNPDNFSPER VKERDSVEWL PFGDGPRNCI
460 470 480 490 500
GMRFGQMQAR SGLALLINRF KFSVCEQTTI PIVYSKKTFL ISSETGIFLK

VERV
Length:504
Mass (Da):58,005
Last modified:December 1, 2000 - v3
Checksum:i3B0C875DAC3D4290
GO

Sequence cautioni

The sequence AAB46609 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Y → S in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti137Y → S in AAM51056 (PubMed:12537569).Curated1
Sequence conflicti376V → D in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti424 – 434DNFSPERVKER → IFFARTSEGS in AAB46609 (PubMed:8973362).CuratedAdd BLAST11
Sequence conflicti448N → L in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti461S → I in AAM51056 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46860 mRNA Translation: AAB46609.1 Different initiation.
AE013599 Genomic DNA Translation: AAF58188.2
AY119196 mRNA Translation: AAM51056.1
PIRiJC5321
RefSeqiNP_523748.2, NM_079024.3
UniGeneiDm.632

Genome annotation databases

EnsemblMetazoaiFBtr0300128; FBpp0289405; FBgn0013771
GeneIDi36663
KEGGidme:Dmel_CG10246

Similar proteinsi

Entry informationi

Entry nameiCP6A9_DROME
AccessioniPrimary (citable) accession number: Q27594
Secondary accession number(s): Q8MRY8, Q9V772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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