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Protein

Cytochrome P450 6a9

Gene

Cyp6a9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi449Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6a9 (EC:1.14.-.-)
Alternative name(s):
CYPVIA9
Gene namesi
Name:Cyp6a9
ORF Names:CG10246
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013771. Cyp6a9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518681 – 504Cytochrome P450 6a9Add BLAST504

Proteomic databases

PaxDbiQ27594.
PRIDEiQ27594.

Expressioni

Gene expression databases

BgeeiFBgn0013771.
GenevisibleiQ27594. DM.

Interactioni

Protein-protein interaction databases

BioGridi62405. 6 interactors.
IntActiQ27594. 5 interactors.
MINTiMINT-334517.
STRINGi7227.FBpp0289405.

Structurei

3D structure databases

ProteinModelPortaliQ27594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
InParanoidiQ27594.
KOiK14999.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ27594.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYSVLLAI VVVLVGYLLL KWRRALHYWQ NLDIPCEEPH ILMGSLTGVQ
60 70 80 90 100
TSRSFSAIWM DYYNKFRGTG PFAGFYWFQR PGILVLDISL AKLILIKEFN
110 120 130 140 150
KFTDRGFYHN TEDDPLSGQL FLLDGQKWKS MRSKLSYTFT SGKMKYMFPT
160 170 180 190 200
VVKVGHEFIE VFGQAMEKSP IVEVRDILAR FTTDVIGTCA FGIECSSLKD
210 220 230 240 250
PEAEFRVMGR RAIFEQRHGP IGIAFINSFQ NLARRLHMKI TLEEAEHFFL
260 270 280 290 300
RIVRETVAFR EKNNIRRNDF MDQLIDLKNS PLTKSESGES VNLTIEEMAA
310 320 330 340 350
QAFVFFGAGF ETSSTTMGFA LYELAQHQDI QDRVRKECQE VIGKYNGEIT
360 370 380 390 400
YESMKDMVYL DQVISETLRL YTVLPVLNRE CLEDYEVPGH PKYVIKKGMP
410 420 430 440 450
VLIPCGAMHR DEKLYANPNT FNPDNFSPER VKERDSVEWL PFGDGPRNCI
460 470 480 490 500
GMRFGQMQAR SGLALLINRF KFSVCEQTTI PIVYSKKTFL ISSETGIFLK

VERV
Length:504
Mass (Da):58,005
Last modified:December 1, 2000 - v3
Checksum:i3B0C875DAC3D4290
GO

Sequence cautioni

The sequence AAB46609 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Y → S in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti137Y → S in AAM51056 (PubMed:12537569).Curated1
Sequence conflicti376V → D in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti424 – 434DNFSPERVKER → IFFARTSEGS in AAB46609 (PubMed:8973362).CuratedAdd BLAST11
Sequence conflicti448N → L in AAB46609 (PubMed:8973362).Curated1
Sequence conflicti461S → I in AAM51056 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46860 mRNA. Translation: AAB46609.1. Different initiation.
AE013599 Genomic DNA. Translation: AAF58188.2.
AY119196 mRNA. Translation: AAM51056.1.
PIRiJC5321.
RefSeqiNP_523748.2. NM_079024.3.
UniGeneiDm.632.

Genome annotation databases

GeneIDi36663.
KEGGidme:Dmel_CG10246.

Similar proteinsi

Entry informationi

Entry nameiCP6A9_DROME
AccessioniPrimary (citable) accession number: Q27594
Secondary accession number(s): Q8MRY8, Q9V772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: November 22, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families