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Q27571

- NOS_DROME

UniProt

Q27571 - NOS_DROME

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Protein

Nitric oxide synthase

Gene

Nos

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full length protein and serve as dominant negative inhibitors of the enzyme activity.3 Publications

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactori

Protein has several cofactor binding sites:
  • hemeBy similarity
  • FADBy similarityNote: Binds 1 FAD.By similarity
  • FMNBy similarityNote: Binds 1 FMN.By similarity

Enzyme regulationi

Stimulated by calcium/calmodulin.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi328 – 3281Iron (heme axial ligand)By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi814 – 84532FMNPROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi957 – 96812FADBy similarityAdd
BLAST
Nucleotide bindingi1100 – 111011FADBy similarityAdd
BLAST
Nucleotide bindingi1175 – 119319NADPBy similarityAdd
BLAST
Nucleotide bindingi1273 – 128715NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. calmodulin binding Source: FlyBase
  2. flavin adenine dinucleotide binding Source: InterPro
  3. FMN binding Source: InterPro
  4. heme binding Source: FlyBase
  5. iron ion binding Source: InterPro
  6. NADP binding Source: InterPro
  7. NADPH-hemoprotein reductase activity Source: RefGenome
  8. nitric-oxide synthase activity Source: UniProtKB

GO - Biological processi

  1. imaginal disc development Source: FlyBase
  2. negative regulation of cell proliferation Source: FlyBase
  3. negative regulation of DNA replication Source: FlyBase
  4. nervous system development Source: FlyBase
  5. nitric oxide biosynthetic process Source: UniProtKB
  6. nitric oxide mediated signal transduction Source: RefGenome
  7. positive regulation of guanylate cyclase activity Source: RefGenome
  8. regulation of heart rate Source: FlyBase
  9. regulation of organ growth Source: FlyBase
  10. synapse assembly Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_180850. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
REACT_181468. Phagosomal maturation (early endosomal stage).
REACT_231836. NOSTRIN mediated eNOS trafficking.
REACT_236156. VEGFR2 mediated vascular permeability.
REACT_239121. NOSIP mediated eNOS trafficking.
REACT_243630. Nitric oxide stimulates guanylate cyclase.
REACT_246558. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthase (EC:1.14.13.39)
Alternative name(s):
dNOS
Gene namesi
Name:Nos
ORF Names:CG6713
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011676. Nos.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13491349Nitric oxide synthasePRO_0000170951Add
BLAST

Proteomic databases

PRIDEiQ27571.

Expressioni

Developmental stagei

Isoform 3 is expressed in larvae only. Isoform 4, isoform 5, isoform 6 and isoform 10 are expressed throughout development from embryos to adults.1 Publication

Gene expression databases

BgeeiQ27571.
ExpressionAtlasiQ27571. differential.

Interactioni

Protein-protein interaction databases

BioGridi60568. 1 interaction.
IntActiQ27571. 1 interaction.
MINTiMINT-964951.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I86model-@217-629[»]
ProteinModelPortaliQ27571.
SMRiQ27571. Positions 217-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini671 – 868198Flavodoxin-likePROSITE-ProRule annotationAdd
BLAST
Domaini928 – 1167240FAD-binding FR-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 66121Calmodulin-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 5128Gln-richAdd
BLAST
Compositional biasi76 – 794Poly-Gly
Compositional biasi145 – 15612Poly-GlyAdd
BLAST

Sequence similaritiesi

Belongs to the NOS family.Curated
Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4362.
GeneTreeiENSGT00620000087711.
InParanoidiQ27571.
KOiK13253.
OMAiMALYYLK.
OrthoDBiEOG79SDW7.
PhylomeDBiQ27571.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q27571-1) [UniParc]FASTAAdd to Basket

Also known as: A, C, dNOS-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQHFTSIFE NLRFVTIKRS TNAQQQQQQQ QQQLQQQQQQ LQQQKAQTQQ
60 70 80 90 100
QNSRKIKTQA TPTLNGNGLL SGNPNGGGGD SSPSHEVDHP GGAQGAQAAG
110 120 130 140 150
GLPSSSGTPL RHHKRASIST ASPPIRERRG TNTSIVVELD GSGSGSGSGG
160 170 180 190 200
GGVGVGQGAG CPPSGSCTAS GKSSRELSPS PKNQQQPRKM SQDYRSRAGS
210 220 230 240 250
FMHLDDEGRS LLMRKPMRLK NIEGRPEVYD TLHCKGREIL SCSKATCTSS
260 270 280 290 300
IMNIGNAAVE ARKSDLILEH AKDFLEQYFT SIKRTSSTAH ETRWKQVRQS
310 320 330 340 350
IETTGHYQLT ETELIYGAKL AWRNSSRCIG RIQWSKLQVF DCRYVTTTSG
360 370 380 390 400
MFEAICNHIK YATNKGNLRS AITIFPQRTD AKHDYRIWNN QLISYAGYKQ
410 420 430 440 450
ADGKIIGDPM NVEFTEVCTK LGWKSKGSEW DILPLVVSAN GHDPDYFDYP
460 470 480 490 500
PELILEVPLT HPKFEWFSDL GLRWYALPAV SSMLFDVGGI QFTATTFSGW
510 520 530 540 550
YMSTEIGSRN LCDTNRRNML ETVALKMQLD TRTPTSLWKD KAVVEMNIAV
560 570 580 590 600
LHSYQSRNVT IVDHHTASES FMKHFENESK LRNGCPADWI WIVPPLSGSI
610 620 630 640 650
TPVFHQEMAL YYLKPSFEYQ DPAWRTHVWK KGRGESKGKK PRRKFNFKQI
660 670 680 690 700
ARAVKFTSKL FGRALSKRIK ATVLYATETG KSEQYAKQLC ELLGHAFNAQ
710 720 730 740 750
IYCMSDYDIS SIEHEALLIV VASTFGNGDP PENGELFSQE LYAMRVQESS
760 770 780 790 800
EHGLQDSSIG SSKSFMKASS RQEFMKLPLQ QVKRIDRWDS LRGSTSDTFT
810 820 830 840 850
EETFGPLSNV RFAVFALGSS AYPNFCAFGQ YVDNILGELG GERLLRVAYG
860 870 880 890 900
DEMCGQEQSF RKWAPEVFKL ACETFCLDPE ESLSDASLAL QNDSLTVNTV
910 920 930 940 950
RLVPSANKGS LDSSLSKYHN KKVHCCKAKA KPHNLTRLSE GAKTTMLLEI
960 970 980 990 1000
CAPGLEYEPG DHVGIFPANR TELVDGLLNR LVGVDNPDEV LQLQLLKEKQ
1010 1020 1030 1040 1050
TSNGIFKCWE PHDKIPPDTL RNLLARFFDL TTPPSRQLLT LLAGFCEDTA
1060 1070 1080 1090 1100
DKERLELLVN DSSAYEDWRH WRLPHLLDVL EEFPSCRPPA PLLLAQLTPL
1110 1120 1130 1140 1150
QPRFYSISSS PRRVSDEIHL TVAIVKYRCE DGQGDERYGV CSNYLSGLRA
1160 1170 1180 1190 1200
DDELFMFVRS ALGFHLPSDR SRPIILIGPG TGIAPFRSFW QEFQVLSDLD
1210 1220 1230 1240 1250
PTAKLPKMWL FFGCRNRDVD LYAEEKAELQ KDQILDRVFL ALSREQAIPK
1260 1270 1280 1290 1300
TYVQDLIEQE FDSLYQLIVQ ERGHIYVCGD VTMAEHVYQT IRKCIAGKEQ
1310 1320 1330 1340
KSEAEVETFL LTLRDESRYH EDIFGITLRT AEIHTKSRAT ARIRMASQP
Length:1,349
Mass (Da):151,715
Last modified:June 10, 2008 - v3
Checksum:iE19D8CBAEFAF76FC
GO
Isoform 2 (identifier: Q27571-2) [UniParc]FASTAAdd to Basket

Also known as: dNOS-2, E

The sequence of this isoform differs from the canonical sequence as follows:
     417-521: Missing.

Show »
Length:1,244
Mass (Da):139,754
Checksum:iAD7AA548C03AE48F
GO
Isoform 3 (identifier: Q27571-3) [UniParc]FASTAAdd to Basket

Also known as: dNOS-3

The sequence of this isoform differs from the canonical sequence as follows:
     201-214: FMHLDDEGRSLLMR → RFFPARRPPVRAAL
     215-1349: Missing.

Show »
Length:214
Mass (Da):22,460
Checksum:iAA970488F5BFBF76
GO
Isoform 4 (identifier: Q27571-4) [UniParc]FASTAAdd to Basket

Also known as: B, dNOS-4, F, J

The sequence of this isoform differs from the canonical sequence as follows:
     736-756: LFSQELYAMRVQESSEHGLQD → VSTPPRKDHTELINGLGPAAF
     757-1349: Missing.

Show »
Length:756
Mass (Da):84,261
Checksum:i1ABA7993149272D0
GO
Isoform 5 (identifier: Q27571-5) [UniParc]FASTAAdd to Basket

Also known as: dNOS-5, H

The sequence of this isoform differs from the canonical sequence as follows:
     701-704: IYCM → VSLT
     705-1349: Missing.

Show »
Length:704
Mass (Da):78,690
Checksum:iEEF32F5F9BB8091E
GO
Isoform 6 (identifier: Q27571-6) [UniParc]FASTAAdd to Basket

Also known as: dNOS-6, I

The sequence of this isoform differs from the canonical sequence as follows:
     701-746: IYCMSDYDIS...FSQELYAMRV → CPVGSVSSDP...WQNKISCKHL
     747-1349: Missing.

Show »
Length:746
Mass (Da):83,144
Checksum:i8449B48E111D7132
GO
Isoform 10 (identifier: Q27571-7) [UniParc]FASTAAdd to Basket

Also known as: dNOS-10, G

The sequence of this isoform differs from the canonical sequence as follows:
     758-1291: Missing.

Show »
Length:815
Mass (Da):91,268
Checksum:i86C08065EBA6C062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201S → A in AAC46882. (PubMed:7568075)Curated
Sequence conflicti24 – 241Q → QQ in AAC46882. (PubMed:7568075)Curated
Sequence conflicti105 – 1051S → L in AAC46882. (PubMed:7568075)Curated
Sequence conflicti287 – 2871S → C in AAC46882. (PubMed:7568075)Curated
Sequence conflicti373 – 3731T → S in AAF25682. (PubMed:11526108)Curated
Sequence conflicti1197 – 11971S → R in AAC46882. (PubMed:7568075)Curated
Sequence conflicti1197 – 11971S → R in AAF25682. (PubMed:11526108)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 21414FMHLD…SLLMR → RFFPARRPPVRAAL in isoform 3. CuratedVSP_003585Add
BLAST
Alternative sequencei215 – 13491135Missing in isoform 3. CuratedVSP_003586Add
BLAST
Alternative sequencei417 – 521105Missing in isoform 2. 1 PublicationVSP_003587Add
BLAST
Alternative sequencei701 – 74646IYCMS…YAMRV → CPVGSVSSDPQDPVQLGLVV VLVSSTCVCKKHLPAAWQNK ISCKHL in isoform 6. CuratedVSP_003590Add
BLAST
Alternative sequencei701 – 7044IYCM → VSLT in isoform 5. CuratedVSP_003588
Alternative sequencei705 – 1349645Missing in isoform 5. CuratedVSP_003589Add
BLAST
Alternative sequencei736 – 75621LFSQE…HGLQD → VSTPPRKDHTELINGLGPAA F in isoform 4. CuratedVSP_003592Add
BLAST
Alternative sequencei747 – 1349603Missing in isoform 6. CuratedVSP_003591Add
BLAST
Alternative sequencei757 – 1349593Missing in isoform 4. CuratedVSP_003593Add
BLAST
Alternative sequencei758 – 1291534Missing in isoform 10. CuratedVSP_003594Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25117 mRNA. Translation: AAC46882.1.
AF215700
, AF215691, AF215692, AF215693, AF215694, AF215695, AF215696, AF215697, AF215698, AF215699 Genomic DNA. Translation: AAF25682.1.
AE014134 Genomic DNA. Translation: AAF53014.1.
AE014134 Genomic DNA. Translation: AAZ66450.1.
AE014134 Genomic DNA. Translation: AAZ66451.1.
AE014134 Genomic DNA. Translation: AAZ66452.1.
AE014134 Genomic DNA. Translation: AAZ66453.1.
AE014134 Genomic DNA. Translation: AAZ66454.1.
AE014134 Genomic DNA. Translation: AAZ66455.1.
AE014134 Genomic DNA. Translation: AAZ66456.1.
AE014134 Genomic DNA. Translation: AAZ66457.1.
BT010016 mRNA. Translation: AAQ22485.1.
PIRiT13254.
RefSeqiNP_001027240.1. NM_001032069.2. [Q27571-4]
NP_001027243.2. NM_001032072.2.
NP_523541.2. NM_078817.4. [Q27571-1]
UniGeneiDm.2707.

Genome annotation databases

EnsemblMetazoaiFBtr0080188; FBpp0079777; FBgn0011676. [Q27571-1]
FBtr0100486; FBpp0099922; FBgn0011676. [Q27571-1]
GeneIDi34495.
KEGGidme:Dmel_CG6713.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25117 mRNA. Translation: AAC46882.1 .
AF215700
, AF215691 , AF215692 , AF215693 , AF215694 , AF215695 , AF215696 , AF215697 , AF215698 , AF215699 Genomic DNA. Translation: AAF25682.1 .
AE014134 Genomic DNA. Translation: AAF53014.1 .
AE014134 Genomic DNA. Translation: AAZ66450.1 .
AE014134 Genomic DNA. Translation: AAZ66451.1 .
AE014134 Genomic DNA. Translation: AAZ66452.1 .
AE014134 Genomic DNA. Translation: AAZ66453.1 .
AE014134 Genomic DNA. Translation: AAZ66454.1 .
AE014134 Genomic DNA. Translation: AAZ66455.1 .
AE014134 Genomic DNA. Translation: AAZ66456.1 .
AE014134 Genomic DNA. Translation: AAZ66457.1 .
BT010016 mRNA. Translation: AAQ22485.1 .
PIRi T13254.
RefSeqi NP_001027240.1. NM_001032069.2. [Q27571-4 ]
NP_001027243.2. NM_001032072.2.
NP_523541.2. NM_078817.4. [Q27571-1 ]
UniGenei Dm.2707.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I86 model - @ 217-629 [» ]
ProteinModelPortali Q27571.
SMRi Q27571. Positions 217-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60568. 1 interaction.
IntActi Q27571. 1 interaction.
MINTi MINT-964951.

Proteomic databases

PRIDEi Q27571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080188 ; FBpp0079777 ; FBgn0011676 . [Q27571-1 ]
FBtr0100486 ; FBpp0099922 ; FBgn0011676 . [Q27571-1 ]
GeneIDi 34495.
KEGGi dme:Dmel_CG6713.

Organism-specific databases

CTDi 34495.
FlyBasei FBgn0011676. Nos.

Phylogenomic databases

eggNOGi COG4362.
GeneTreei ENSGT00620000087711.
InParanoidi Q27571.
KOi K13253.
OMAi MALYYLK.
OrthoDBi EOG79SDW7.
PhylomeDBi Q27571.

Enzyme and pathway databases

Reactomei REACT_180850. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
REACT_181468. Phagosomal maturation (early endosomal stage).
REACT_231836. NOSTRIN mediated eNOS trafficking.
REACT_236156. VEGFR2 mediated vascular permeability.
REACT_239121. NOSIP mediated eNOS trafficking.
REACT_243630. Nitric oxide stimulates guanylate cyclase.
REACT_246558. eNOS activation.

Miscellaneous databases

GenomeRNAii 34495.
NextBioi 788761.
PROi Q27571.

Gene expression databases

Bgeei Q27571.
ExpressionAtlasi Q27571. differential.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000333. NOS. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase."
    Regulski M., Tully T.
    Proc. Natl. Acad. Sci. U.S.A. 92:9072-9076(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION.
    Tissue: Head.
  2. "The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators."
    Stasiv Y., Regulski M., Kuzin B., Tully T., Enikolopov G.
    J. Biol. Chem. 276:42241-42251(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE.
    Tissue: Embryo and Larva.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Characterization of Drosophila nitric oxide synthase: a biochemical study."
    Sengupta R., Sahoo R., Mukherjee S., Regulski M., Tully T., Stuehr D.J., Ghosh S.
    Biochem. Biophys. Res. Commun. 306:590-597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNOS_DROME
AccessioniPrimary (citable) accession number: Q27571
Secondary accession number(s): A4V0K9
, A4V0L0, Q4ABG3, Q4ABG4, Q4ABG5, Q4ABG6, Q4ABG7, Q7YU33, Q9U096, Q9VKP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 10, 2008
Last modified: November 26, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3