SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q27571

- NOS_DROME

UniProt

Q27571 - NOS_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nitric oxide synthase

Gene
Nos, CG6713
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full length protein and serve as dominant negative inhibitors of the enzyme activity.3 Publications

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactori

Heme group By similarity.
Binds 1 FAD By similarity.
Binds 1 FMN By similarity.

Enzyme regulationi

Stimulated by calcium/calmodulin.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi328 – 3281Iron (heme axial ligand) By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi814 – 84532FMN By similarityAdd
BLAST
Nucleotide bindingi957 – 96812FAD By similarityAdd
BLAST
Nucleotide bindingi1100 – 111011FAD By similarityAdd
BLAST
Nucleotide bindingi1175 – 119319NADP By similarityAdd
BLAST
Nucleotide bindingi1273 – 128715NADP By similarityAdd
BLAST

GO - Molecular functioni

  1. calmodulin binding Source: FlyBase
  2. flavin adenine dinucleotide binding Source: InterPro
  3. FMN binding Source: InterPro
  4. heme binding Source: FlyBase
  5. iron ion binding Source: InterPro
  6. NADP binding Source: InterPro
  7. NADPH-hemoprotein reductase activity Source: RefGenome
  8. nitric-oxide synthase activity Source: UniProtKB

GO - Biological processi

  1. imaginal disc development Source: FlyBase
  2. negative regulation of cell proliferation Source: FlyBase
  3. negative regulation of DNA replication Source: FlyBase
  4. nervous system development Source: FlyBase
  5. nitric oxide biosynthetic process Source: UniProtKB
  6. nitric oxide mediated signal transduction Source: RefGenome
  7. positive regulation of guanylate cyclase activity Source: RefGenome
  8. regulation of heart rate Source: FlyBase
  9. regulation of organ growth Source: FlyBase
  10. synapse assembly Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthase (EC:1.14.13.39)
Alternative name(s):
dNOS
Gene namesi
Name:Nos
ORF Names:CG6713
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011676. Nos.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13491349Nitric oxide synthasePRO_0000170951Add
BLAST

Proteomic databases

PRIDEiQ27571.

Expressioni

Developmental stagei

Isoform 3 is expressed in larvae only. Isoform 4, isoform 5, isoform 6 and isoform 10 are expressed throughout development from embryos to adults.1 Publication

Gene expression databases

BgeeiQ27571.

Interactioni

Protein-protein interaction databases

BioGridi60568. 1 interaction.
IntActiQ27571. 1 interaction.
MINTiMINT-964951.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I86model-@217-629[»]
ProteinModelPortaliQ27571.
SMRiQ27571. Positions 217-630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini671 – 868198Flavodoxin-likeAdd
BLAST
Domaini928 – 1167240FAD-binding FR-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 66121Calmodulin-binding Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 5128Gln-richAdd
BLAST
Compositional biasi76 – 794Poly-Gly
Compositional biasi145 – 15612Poly-GlyAdd
BLAST

Sequence similaritiesi

Belongs to the NOS family.

Phylogenomic databases

eggNOGiCOG4362.
GeneTreeiENSGT00620000087711.
InParanoidiQ27571.
KOiK13253.
OMAiMALYYLK.
OrthoDBiEOG79SDW7.
PhylomeDBiQ27571.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q27571-1) [UniParc]FASTAAdd to Basket

Also known as: A, C, dNOS-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQHFTSIFE NLRFVTIKRS TNAQQQQQQQ QQQLQQQQQQ LQQQKAQTQQ     50
QNSRKIKTQA TPTLNGNGLL SGNPNGGGGD SSPSHEVDHP GGAQGAQAAG 100
GLPSSSGTPL RHHKRASIST ASPPIRERRG TNTSIVVELD GSGSGSGSGG 150
GGVGVGQGAG CPPSGSCTAS GKSSRELSPS PKNQQQPRKM SQDYRSRAGS 200
FMHLDDEGRS LLMRKPMRLK NIEGRPEVYD TLHCKGREIL SCSKATCTSS 250
IMNIGNAAVE ARKSDLILEH AKDFLEQYFT SIKRTSSTAH ETRWKQVRQS 300
IETTGHYQLT ETELIYGAKL AWRNSSRCIG RIQWSKLQVF DCRYVTTTSG 350
MFEAICNHIK YATNKGNLRS AITIFPQRTD AKHDYRIWNN QLISYAGYKQ 400
ADGKIIGDPM NVEFTEVCTK LGWKSKGSEW DILPLVVSAN GHDPDYFDYP 450
PELILEVPLT HPKFEWFSDL GLRWYALPAV SSMLFDVGGI QFTATTFSGW 500
YMSTEIGSRN LCDTNRRNML ETVALKMQLD TRTPTSLWKD KAVVEMNIAV 550
LHSYQSRNVT IVDHHTASES FMKHFENESK LRNGCPADWI WIVPPLSGSI 600
TPVFHQEMAL YYLKPSFEYQ DPAWRTHVWK KGRGESKGKK PRRKFNFKQI 650
ARAVKFTSKL FGRALSKRIK ATVLYATETG KSEQYAKQLC ELLGHAFNAQ 700
IYCMSDYDIS SIEHEALLIV VASTFGNGDP PENGELFSQE LYAMRVQESS 750
EHGLQDSSIG SSKSFMKASS RQEFMKLPLQ QVKRIDRWDS LRGSTSDTFT 800
EETFGPLSNV RFAVFALGSS AYPNFCAFGQ YVDNILGELG GERLLRVAYG 850
DEMCGQEQSF RKWAPEVFKL ACETFCLDPE ESLSDASLAL QNDSLTVNTV 900
RLVPSANKGS LDSSLSKYHN KKVHCCKAKA KPHNLTRLSE GAKTTMLLEI 950
CAPGLEYEPG DHVGIFPANR TELVDGLLNR LVGVDNPDEV LQLQLLKEKQ 1000
TSNGIFKCWE PHDKIPPDTL RNLLARFFDL TTPPSRQLLT LLAGFCEDTA 1050
DKERLELLVN DSSAYEDWRH WRLPHLLDVL EEFPSCRPPA PLLLAQLTPL 1100
QPRFYSISSS PRRVSDEIHL TVAIVKYRCE DGQGDERYGV CSNYLSGLRA 1150
DDELFMFVRS ALGFHLPSDR SRPIILIGPG TGIAPFRSFW QEFQVLSDLD 1200
PTAKLPKMWL FFGCRNRDVD LYAEEKAELQ KDQILDRVFL ALSREQAIPK 1250
TYVQDLIEQE FDSLYQLIVQ ERGHIYVCGD VTMAEHVYQT IRKCIAGKEQ 1300
KSEAEVETFL LTLRDESRYH EDIFGITLRT AEIHTKSRAT ARIRMASQP 1349
Length:1,349
Mass (Da):151,715
Last modified:June 10, 2008 - v3
Checksum:iE19D8CBAEFAF76FC
GO
Isoform 2 (identifier: Q27571-2) [UniParc]FASTAAdd to Basket

Also known as: dNOS-2, E

The sequence of this isoform differs from the canonical sequence as follows:
     417-521: Missing.

Show »
Length:1,244
Mass (Da):139,754
Checksum:iAD7AA548C03AE48F
GO
Isoform 3 (identifier: Q27571-3) [UniParc]FASTAAdd to Basket

Also known as: dNOS-3

The sequence of this isoform differs from the canonical sequence as follows:
     201-214: FMHLDDEGRSLLMR → RFFPARRPPVRAAL
     215-1349: Missing.

Show »
Length:214
Mass (Da):22,460
Checksum:iAA970488F5BFBF76
GO
Isoform 4 (identifier: Q27571-4) [UniParc]FASTAAdd to Basket

Also known as: B, dNOS-4, F, J

The sequence of this isoform differs from the canonical sequence as follows:
     736-756: LFSQELYAMRVQESSEHGLQD → VSTPPRKDHTELINGLGPAAF
     757-1349: Missing.

Show »
Length:756
Mass (Da):84,261
Checksum:i1ABA7993149272D0
GO
Isoform 5 (identifier: Q27571-5) [UniParc]FASTAAdd to Basket

Also known as: dNOS-5, H

The sequence of this isoform differs from the canonical sequence as follows:
     701-704: IYCM → VSLT
     705-1349: Missing.

Show »
Length:704
Mass (Da):78,690
Checksum:iEEF32F5F9BB8091E
GO
Isoform 6 (identifier: Q27571-6) [UniParc]FASTAAdd to Basket

Also known as: dNOS-6, I

The sequence of this isoform differs from the canonical sequence as follows:
     701-746: IYCMSDYDIS...FSQELYAMRV → CPVGSVSSDP...WQNKISCKHL
     747-1349: Missing.

Show »
Length:746
Mass (Da):83,144
Checksum:i8449B48E111D7132
GO
Isoform 10 (identifier: Q27571-7) [UniParc]FASTAAdd to Basket

Also known as: dNOS-10, G

The sequence of this isoform differs from the canonical sequence as follows:
     758-1291: Missing.

Show »
Length:815
Mass (Da):91,268
Checksum:i86C08065EBA6C062
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 21414FMHLD…SLLMR → RFFPARRPPVRAAL in isoform 3. VSP_003585Add
BLAST
Alternative sequencei215 – 13491135Missing in isoform 3. VSP_003586Add
BLAST
Alternative sequencei417 – 521105Missing in isoform 2. VSP_003587Add
BLAST
Alternative sequencei701 – 74646IYCMS…YAMRV → CPVGSVSSDPQDPVQLGLVV VLVSSTCVCKKHLPAAWQNK ISCKHL in isoform 6. VSP_003590Add
BLAST
Alternative sequencei701 – 7044IYCM → VSLT in isoform 5. VSP_003588
Alternative sequencei705 – 1349645Missing in isoform 5. VSP_003589Add
BLAST
Alternative sequencei736 – 75621LFSQE…HGLQD → VSTPPRKDHTELINGLGPAA F in isoform 4. VSP_003592Add
BLAST
Alternative sequencei747 – 1349603Missing in isoform 6. VSP_003591Add
BLAST
Alternative sequencei757 – 1349593Missing in isoform 4. VSP_003593Add
BLAST
Alternative sequencei758 – 1291534Missing in isoform 10. VSP_003594Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201S → A in AAC46882. 1 Publication
Sequence conflicti24 – 241Q → QQ in AAC46882. 1 Publication
Sequence conflicti105 – 1051S → L in AAC46882. 1 Publication
Sequence conflicti287 – 2871S → C in AAC46882. 1 Publication
Sequence conflicti373 – 3731T → S in AAF25682. 1 Publication
Sequence conflicti1197 – 11971S → R in AAC46882. 1 Publication
Sequence conflicti1197 – 11971S → R in AAF25682. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25117 mRNA. Translation: AAC46882.1.
AF215700
, AF215691, AF215692, AF215693, AF215694, AF215695, AF215696, AF215697, AF215698, AF215699 Genomic DNA. Translation: AAF25682.1.
AE014134 Genomic DNA. Translation: AAF53014.1.
AE014134 Genomic DNA. Translation: AAZ66450.1.
AE014134 Genomic DNA. Translation: AAZ66451.1.
AE014134 Genomic DNA. Translation: AAZ66452.1.
AE014134 Genomic DNA. Translation: AAZ66453.1.
AE014134 Genomic DNA. Translation: AAZ66454.1.
AE014134 Genomic DNA. Translation: AAZ66455.1.
AE014134 Genomic DNA. Translation: AAZ66456.1.
AE014134 Genomic DNA. Translation: AAZ66457.1.
BT010016 mRNA. Translation: AAQ22485.1.
PIRiT13254.
RefSeqiNP_001027238.1. NM_001032067.1. [Q27571-5]
NP_001027239.1. NM_001032068.1. [Q27571-7]
NP_001027240.1. NM_001032069.1. [Q27571-4]
NP_001027241.1. NM_001032070.1. [Q27571-2]
NP_001027243.1. NM_001032072.1. [Q27571-1]
NP_001027244.1. NM_001032073.1. [Q27571-4]
NP_001027245.1. NM_001032074.1. [Q27571-4]
NP_001027246.1. NM_001032075.1. [Q27571-6]
NP_523541.2. NM_078817.3. [Q27571-1]
UniGeneiDm.2707.

Genome annotation databases

EnsemblMetazoaiFBtr0080188; FBpp0079777; FBgn0011676. [Q27571-1]
FBtr0100486; FBpp0099922; FBgn0011676. [Q27571-1]
GeneIDi34495.
KEGGidme:Dmel_CG6713.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25117 mRNA. Translation: AAC46882.1 .
AF215700
, AF215691 , AF215692 , AF215693 , AF215694 , AF215695 , AF215696 , AF215697 , AF215698 , AF215699 Genomic DNA. Translation: AAF25682.1 .
AE014134 Genomic DNA. Translation: AAF53014.1 .
AE014134 Genomic DNA. Translation: AAZ66450.1 .
AE014134 Genomic DNA. Translation: AAZ66451.1 .
AE014134 Genomic DNA. Translation: AAZ66452.1 .
AE014134 Genomic DNA. Translation: AAZ66453.1 .
AE014134 Genomic DNA. Translation: AAZ66454.1 .
AE014134 Genomic DNA. Translation: AAZ66455.1 .
AE014134 Genomic DNA. Translation: AAZ66456.1 .
AE014134 Genomic DNA. Translation: AAZ66457.1 .
BT010016 mRNA. Translation: AAQ22485.1 .
PIRi T13254.
RefSeqi NP_001027238.1. NM_001032067.1. [Q27571-5 ]
NP_001027239.1. NM_001032068.1. [Q27571-7 ]
NP_001027240.1. NM_001032069.1. [Q27571-4 ]
NP_001027241.1. NM_001032070.1. [Q27571-2 ]
NP_001027243.1. NM_001032072.1. [Q27571-1 ]
NP_001027244.1. NM_001032073.1. [Q27571-4 ]
NP_001027245.1. NM_001032074.1. [Q27571-4 ]
NP_001027246.1. NM_001032075.1. [Q27571-6 ]
NP_523541.2. NM_078817.3. [Q27571-1 ]
UniGenei Dm.2707.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I86 model - @ 217-629 [» ]
ProteinModelPortali Q27571.
SMRi Q27571. Positions 217-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60568. 1 interaction.
IntActi Q27571. 1 interaction.
MINTi MINT-964951.

Proteomic databases

PRIDEi Q27571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080188 ; FBpp0079777 ; FBgn0011676 . [Q27571-1 ]
FBtr0100486 ; FBpp0099922 ; FBgn0011676 . [Q27571-1 ]
GeneIDi 34495.
KEGGi dme:Dmel_CG6713.

Organism-specific databases

CTDi 34495.
FlyBasei FBgn0011676. Nos.

Phylogenomic databases

eggNOGi COG4362.
GeneTreei ENSGT00620000087711.
InParanoidi Q27571.
KOi K13253.
OMAi MALYYLK.
OrthoDBi EOG79SDW7.
PhylomeDBi Q27571.

Miscellaneous databases

GenomeRNAii 34495.
NextBioi 788761.
PROi Q27571.

Gene expression databases

Bgeei Q27571.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000333. NOS. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase."
    Regulski M., Tully T.
    Proc. Natl. Acad. Sci. U.S.A. 92:9072-9076(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION.
    Tissue: Head.
  2. "The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators."
    Stasiv Y., Regulski M., Kuzin B., Tully T., Enikolopov G.
    J. Biol. Chem. 276:42241-42251(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE.
    Tissue: Embryo and Larva.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Characterization of Drosophila nitric oxide synthase: a biochemical study."
    Sengupta R., Sahoo R., Mukherjee S., Regulski M., Tully T., Stuehr D.J., Ghosh S.
    Biochem. Biophys. Res. Commun. 306:590-597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNOS_DROME
AccessioniPrimary (citable) accession number: Q27571
Secondary accession number(s): A4V0K9
, A4V0L0, Q4ABG3, Q4ABG4, Q4ABG5, Q4ABG6, Q4ABG7, Q7YU33, Q9U096, Q9VKP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi