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Q27571

- NOS_DROME

UniProt

Q27571 - NOS_DROME

Protein

Nitric oxide synthase

Gene

Nos

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full length protein and serve as dominant negative inhibitors of the enzyme activity.3 Publications

    Catalytic activityi

    2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

    Cofactori

    Heme group.By similarity
    Binds 1 FAD.By similarity
    Binds 1 FMN.By similarity

    Enzyme regulationi

    Stimulated by calcium/calmodulin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi328 – 3281Iron (heme axial ligand)By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi814 – 84532FMNPROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi957 – 96812FADBy similarityAdd
    BLAST
    Nucleotide bindingi1100 – 111011FADBy similarityAdd
    BLAST
    Nucleotide bindingi1175 – 119319NADPBy similarityAdd
    BLAST
    Nucleotide bindingi1273 – 128715NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. calmodulin binding Source: FlyBase
    2. flavin adenine dinucleotide binding Source: InterPro
    3. FMN binding Source: InterPro
    4. heme binding Source: FlyBase
    5. iron ion binding Source: InterPro
    6. NADP binding Source: InterPro
    7. NADPH-hemoprotein reductase activity Source: RefGenome
    8. nitric-oxide synthase activity Source: UniProtKB

    GO - Biological processi

    1. imaginal disc development Source: FlyBase
    2. negative regulation of cell proliferation Source: FlyBase
    3. negative regulation of DNA replication Source: FlyBase
    4. nervous system development Source: FlyBase
    5. nitric oxide biosynthetic process Source: UniProtKB
    6. nitric oxide mediated signal transduction Source: RefGenome
    7. positive regulation of guanylate cyclase activity Source: RefGenome
    8. regulation of heart rate Source: FlyBase
    9. regulation of organ growth Source: FlyBase
    10. synapse assembly Source: FlyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calmodulin-binding, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitric oxide synthase (EC:1.14.13.39)
    Alternative name(s):
    dNOS
    Gene namesi
    Name:Nos
    ORF Names:CG6713
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0011676. Nos.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13491349Nitric oxide synthasePRO_0000170951Add
    BLAST

    Proteomic databases

    PRIDEiQ27571.

    Expressioni

    Developmental stagei

    Isoform 3 is expressed in larvae only. Isoform 4, isoform 5, isoform 6 and isoform 10 are expressed throughout development from embryos to adults.1 Publication

    Gene expression databases

    BgeeiQ27571.

    Interactioni

    Protein-protein interaction databases

    BioGridi60568. 1 interaction.
    IntActiQ27571. 1 interaction.
    MINTiMINT-964951.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2I86model-@217-629[»]
    ProteinModelPortaliQ27571.
    SMRiQ27571. Positions 217-630.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini671 – 868198Flavodoxin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini928 – 1167240FAD-binding FR-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni641 – 66121Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 5128Gln-richAdd
    BLAST
    Compositional biasi76 – 794Poly-Gly
    Compositional biasi145 – 15612Poly-GlyAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NOS family.Curated
    Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation
    Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4362.
    GeneTreeiENSGT00620000087711.
    InParanoidiQ27571.
    KOiK13253.
    OMAiMALYYLK.
    OrthoDBiEOG79SDW7.
    PhylomeDBiQ27571.

    Family and domain databases

    Gene3Di1.20.990.10. 1 hit.
    3.40.50.360. 2 hits.
    3.90.340.10. 1 hit.
    InterProiIPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR012144. NOS_euk.
    IPR004030. NOS_N.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    PF02898. NO_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000333. NOS. 1 hit.
    PRINTSiPR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMiSSF52218. SSF52218. 1 hit.
    SSF56512. SSF56512. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    PS60001. NOS. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q27571-1) [UniParc]FASTAAdd to Basket

    Also known as: A, C, dNOS-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQHFTSIFE NLRFVTIKRS TNAQQQQQQQ QQQLQQQQQQ LQQQKAQTQQ     50
    QNSRKIKTQA TPTLNGNGLL SGNPNGGGGD SSPSHEVDHP GGAQGAQAAG 100
    GLPSSSGTPL RHHKRASIST ASPPIRERRG TNTSIVVELD GSGSGSGSGG 150
    GGVGVGQGAG CPPSGSCTAS GKSSRELSPS PKNQQQPRKM SQDYRSRAGS 200
    FMHLDDEGRS LLMRKPMRLK NIEGRPEVYD TLHCKGREIL SCSKATCTSS 250
    IMNIGNAAVE ARKSDLILEH AKDFLEQYFT SIKRTSSTAH ETRWKQVRQS 300
    IETTGHYQLT ETELIYGAKL AWRNSSRCIG RIQWSKLQVF DCRYVTTTSG 350
    MFEAICNHIK YATNKGNLRS AITIFPQRTD AKHDYRIWNN QLISYAGYKQ 400
    ADGKIIGDPM NVEFTEVCTK LGWKSKGSEW DILPLVVSAN GHDPDYFDYP 450
    PELILEVPLT HPKFEWFSDL GLRWYALPAV SSMLFDVGGI QFTATTFSGW 500
    YMSTEIGSRN LCDTNRRNML ETVALKMQLD TRTPTSLWKD KAVVEMNIAV 550
    LHSYQSRNVT IVDHHTASES FMKHFENESK LRNGCPADWI WIVPPLSGSI 600
    TPVFHQEMAL YYLKPSFEYQ DPAWRTHVWK KGRGESKGKK PRRKFNFKQI 650
    ARAVKFTSKL FGRALSKRIK ATVLYATETG KSEQYAKQLC ELLGHAFNAQ 700
    IYCMSDYDIS SIEHEALLIV VASTFGNGDP PENGELFSQE LYAMRVQESS 750
    EHGLQDSSIG SSKSFMKASS RQEFMKLPLQ QVKRIDRWDS LRGSTSDTFT 800
    EETFGPLSNV RFAVFALGSS AYPNFCAFGQ YVDNILGELG GERLLRVAYG 850
    DEMCGQEQSF RKWAPEVFKL ACETFCLDPE ESLSDASLAL QNDSLTVNTV 900
    RLVPSANKGS LDSSLSKYHN KKVHCCKAKA KPHNLTRLSE GAKTTMLLEI 950
    CAPGLEYEPG DHVGIFPANR TELVDGLLNR LVGVDNPDEV LQLQLLKEKQ 1000
    TSNGIFKCWE PHDKIPPDTL RNLLARFFDL TTPPSRQLLT LLAGFCEDTA 1050
    DKERLELLVN DSSAYEDWRH WRLPHLLDVL EEFPSCRPPA PLLLAQLTPL 1100
    QPRFYSISSS PRRVSDEIHL TVAIVKYRCE DGQGDERYGV CSNYLSGLRA 1150
    DDELFMFVRS ALGFHLPSDR SRPIILIGPG TGIAPFRSFW QEFQVLSDLD 1200
    PTAKLPKMWL FFGCRNRDVD LYAEEKAELQ KDQILDRVFL ALSREQAIPK 1250
    TYVQDLIEQE FDSLYQLIVQ ERGHIYVCGD VTMAEHVYQT IRKCIAGKEQ 1300
    KSEAEVETFL LTLRDESRYH EDIFGITLRT AEIHTKSRAT ARIRMASQP 1349
    Length:1,349
    Mass (Da):151,715
    Last modified:June 10, 2008 - v3
    Checksum:iE19D8CBAEFAF76FC
    GO
    Isoform 2 (identifier: Q27571-2) [UniParc]FASTAAdd to Basket

    Also known as: dNOS-2, E

    The sequence of this isoform differs from the canonical sequence as follows:
         417-521: Missing.

    Show »
    Length:1,244
    Mass (Da):139,754
    Checksum:iAD7AA548C03AE48F
    GO
    Isoform 3 (identifier: Q27571-3) [UniParc]FASTAAdd to Basket

    Also known as: dNOS-3

    The sequence of this isoform differs from the canonical sequence as follows:
         201-214: FMHLDDEGRSLLMR → RFFPARRPPVRAAL
         215-1349: Missing.

    Show »
    Length:214
    Mass (Da):22,460
    Checksum:iAA970488F5BFBF76
    GO
    Isoform 4 (identifier: Q27571-4) [UniParc]FASTAAdd to Basket

    Also known as: B, dNOS-4, F, J

    The sequence of this isoform differs from the canonical sequence as follows:
         736-756: LFSQELYAMRVQESSEHGLQD → VSTPPRKDHTELINGLGPAAF
         757-1349: Missing.

    Show »
    Length:756
    Mass (Da):84,261
    Checksum:i1ABA7993149272D0
    GO
    Isoform 5 (identifier: Q27571-5) [UniParc]FASTAAdd to Basket

    Also known as: dNOS-5, H

    The sequence of this isoform differs from the canonical sequence as follows:
         701-704: IYCM → VSLT
         705-1349: Missing.

    Show »
    Length:704
    Mass (Da):78,690
    Checksum:iEEF32F5F9BB8091E
    GO
    Isoform 6 (identifier: Q27571-6) [UniParc]FASTAAdd to Basket

    Also known as: dNOS-6, I

    The sequence of this isoform differs from the canonical sequence as follows:
         701-746: IYCMSDYDIS...FSQELYAMRV → CPVGSVSSDP...WQNKISCKHL
         747-1349: Missing.

    Show »
    Length:746
    Mass (Da):83,144
    Checksum:i8449B48E111D7132
    GO
    Isoform 10 (identifier: Q27571-7) [UniParc]FASTAAdd to Basket

    Also known as: dNOS-10, G

    The sequence of this isoform differs from the canonical sequence as follows:
         758-1291: Missing.

    Show »
    Length:815
    Mass (Da):91,268
    Checksum:i86C08065EBA6C062
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201S → A in AAC46882. (PubMed:7568075)Curated
    Sequence conflicti24 – 241Q → QQ in AAC46882. (PubMed:7568075)Curated
    Sequence conflicti105 – 1051S → L in AAC46882. (PubMed:7568075)Curated
    Sequence conflicti287 – 2871S → C in AAC46882. (PubMed:7568075)Curated
    Sequence conflicti373 – 3731T → S in AAF25682. (PubMed:11526108)Curated
    Sequence conflicti1197 – 11971S → R in AAC46882. (PubMed:7568075)Curated
    Sequence conflicti1197 – 11971S → R in AAF25682. (PubMed:11526108)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei201 – 21414FMHLD…SLLMR → RFFPARRPPVRAAL in isoform 3. CuratedVSP_003585Add
    BLAST
    Alternative sequencei215 – 13491135Missing in isoform 3. CuratedVSP_003586Add
    BLAST
    Alternative sequencei417 – 521105Missing in isoform 2. 1 PublicationVSP_003587Add
    BLAST
    Alternative sequencei701 – 74646IYCMS…YAMRV → CPVGSVSSDPQDPVQLGLVV VLVSSTCVCKKHLPAAWQNK ISCKHL in isoform 6. CuratedVSP_003590Add
    BLAST
    Alternative sequencei701 – 7044IYCM → VSLT in isoform 5. CuratedVSP_003588
    Alternative sequencei705 – 1349645Missing in isoform 5. CuratedVSP_003589Add
    BLAST
    Alternative sequencei736 – 75621LFSQE…HGLQD → VSTPPRKDHTELINGLGPAA F in isoform 4. CuratedVSP_003592Add
    BLAST
    Alternative sequencei747 – 1349603Missing in isoform 6. CuratedVSP_003591Add
    BLAST
    Alternative sequencei757 – 1349593Missing in isoform 4. CuratedVSP_003593Add
    BLAST
    Alternative sequencei758 – 1291534Missing in isoform 10. CuratedVSP_003594Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25117 mRNA. Translation: AAC46882.1.
    AF215700
    , AF215691, AF215692, AF215693, AF215694, AF215695, AF215696, AF215697, AF215698, AF215699 Genomic DNA. Translation: AAF25682.1.
    AE014134 Genomic DNA. Translation: AAF53014.1.
    AE014134 Genomic DNA. Translation: AAZ66450.1.
    AE014134 Genomic DNA. Translation: AAZ66451.1.
    AE014134 Genomic DNA. Translation: AAZ66452.1.
    AE014134 Genomic DNA. Translation: AAZ66453.1.
    AE014134 Genomic DNA. Translation: AAZ66454.1.
    AE014134 Genomic DNA. Translation: AAZ66455.1.
    AE014134 Genomic DNA. Translation: AAZ66456.1.
    AE014134 Genomic DNA. Translation: AAZ66457.1.
    BT010016 mRNA. Translation: AAQ22485.1.
    PIRiT13254.
    RefSeqiNP_001027238.1. NM_001032067.1. [Q27571-5]
    NP_001027239.1. NM_001032068.1. [Q27571-7]
    NP_001027240.1. NM_001032069.1. [Q27571-4]
    NP_001027241.1. NM_001032070.1. [Q27571-2]
    NP_001027243.1. NM_001032072.1. [Q27571-1]
    NP_001027244.1. NM_001032073.1. [Q27571-4]
    NP_001027245.1. NM_001032074.1. [Q27571-4]
    NP_001027246.1. NM_001032075.1. [Q27571-6]
    NP_523541.2. NM_078817.3. [Q27571-1]
    UniGeneiDm.2707.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080188; FBpp0079777; FBgn0011676. [Q27571-1]
    FBtr0100486; FBpp0099922; FBgn0011676. [Q27571-1]
    GeneIDi34495.
    KEGGidme:Dmel_CG6713.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25117 mRNA. Translation: AAC46882.1 .
    AF215700
    , AF215691 , AF215692 , AF215693 , AF215694 , AF215695 , AF215696 , AF215697 , AF215698 , AF215699 Genomic DNA. Translation: AAF25682.1 .
    AE014134 Genomic DNA. Translation: AAF53014.1 .
    AE014134 Genomic DNA. Translation: AAZ66450.1 .
    AE014134 Genomic DNA. Translation: AAZ66451.1 .
    AE014134 Genomic DNA. Translation: AAZ66452.1 .
    AE014134 Genomic DNA. Translation: AAZ66453.1 .
    AE014134 Genomic DNA. Translation: AAZ66454.1 .
    AE014134 Genomic DNA. Translation: AAZ66455.1 .
    AE014134 Genomic DNA. Translation: AAZ66456.1 .
    AE014134 Genomic DNA. Translation: AAZ66457.1 .
    BT010016 mRNA. Translation: AAQ22485.1 .
    PIRi T13254.
    RefSeqi NP_001027238.1. NM_001032067.1. [Q27571-5 ]
    NP_001027239.1. NM_001032068.1. [Q27571-7 ]
    NP_001027240.1. NM_001032069.1. [Q27571-4 ]
    NP_001027241.1. NM_001032070.1. [Q27571-2 ]
    NP_001027243.1. NM_001032072.1. [Q27571-1 ]
    NP_001027244.1. NM_001032073.1. [Q27571-4 ]
    NP_001027245.1. NM_001032074.1. [Q27571-4 ]
    NP_001027246.1. NM_001032075.1. [Q27571-6 ]
    NP_523541.2. NM_078817.3. [Q27571-1 ]
    UniGenei Dm.2707.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2I86 model - @ 217-629 [» ]
    ProteinModelPortali Q27571.
    SMRi Q27571. Positions 217-630.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60568. 1 interaction.
    IntActi Q27571. 1 interaction.
    MINTi MINT-964951.

    Proteomic databases

    PRIDEi Q27571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080188 ; FBpp0079777 ; FBgn0011676 . [Q27571-1 ]
    FBtr0100486 ; FBpp0099922 ; FBgn0011676 . [Q27571-1 ]
    GeneIDi 34495.
    KEGGi dme:Dmel_CG6713.

    Organism-specific databases

    CTDi 34495.
    FlyBasei FBgn0011676. Nos.

    Phylogenomic databases

    eggNOGi COG4362.
    GeneTreei ENSGT00620000087711.
    InParanoidi Q27571.
    KOi K13253.
    OMAi MALYYLK.
    OrthoDBi EOG79SDW7.
    PhylomeDBi Q27571.

    Miscellaneous databases

    GenomeRNAii 34495.
    NextBioi 788761.
    PROi Q27571.

    Gene expression databases

    Bgeei Q27571.

    Family and domain databases

    Gene3Di 1.20.990.10. 1 hit.
    3.40.50.360. 2 hits.
    3.90.340.10. 1 hit.
    InterProi IPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR012144. NOS_euk.
    IPR004030. NOS_N.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    PF02898. NO_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000333. NOS. 1 hit.
    PRINTSi PR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMi SSF52218. SSF52218. 1 hit.
    SSF56512. SSF56512. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    PS60001. NOS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase."
      Regulski M., Tully T.
      Proc. Natl. Acad. Sci. U.S.A. 92:9072-9076(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION.
      Tissue: Head.
    2. "The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators."
      Stasiv Y., Regulski M., Kuzin B., Tully T., Enikolopov G.
      J. Biol. Chem. 276:42241-42251(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ALTERNATIVE SPLICING, DEVELOPMENTAL STAGE.
      Tissue: Embryo and Larva.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Berkeley.
      Tissue: Embryo.
    6. "Characterization of Drosophila nitric oxide synthase: a biochemical study."
      Sengupta R., Sahoo R., Mukherjee S., Regulski M., Tully T., Stuehr D.J., Ghosh S.
      Biochem. Biophys. Res. Commun. 306:590-597(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNOS_DROME
    AccessioniPrimary (citable) accession number: Q27571
    Secondary accession number(s): A4V0K9
    , A4V0L0, Q4ABG3, Q4ABG4, Q4ABG5, Q4ABG6, Q4ABG7, Q7YU33, Q9U096, Q9VKP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3