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Protein

Proteasome subunit alpha type-1

Gene

psmA1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: dictyBase
  • ubiquitin-dependent protein catabolic process Source: dictyBase

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.976

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit C2
Gene namesi
Name:psmA1
Synonyms:prtC
ORF Names:DDB_G0282363
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282363 psmA1

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • phagocytic vesicle Source: dictyBase
  • proteasome core complex, alpha-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240671 – 248Proteasome subunit alpha type-1Add BLAST248

Proteomic databases

PaxDbiQ27562

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0214956

Structurei

3D structure databases

ProteinModelPortaliQ27562
SMRiQ27562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
InParanoidiQ27562
KOiK02725
OMAiFMKQQCL
PhylomeDBiQ27562

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q27562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRNQYDSDI TTFSPSGRIH QIEYAMEAVK QGGAAVALKS KQFAVLVSLK
60 70 80 90 100
RSSSELGSYQ KKIFVVDDHV GIAISGLTAD ARMLCNYMRN ECSNYNYVYE
110 120 130 140 150
SQMRVERLVT KVADKHQVHT QRYGRRPYGV GLLVAGYDQL GAHIYQTCPS
160 170 180 190 200
GNFYDYKSIS IGSRSQSAKT YLEKHFESFE ECTLEQLITH GLRALRETIP
210 220 230 240
NTDDTLNSKN VSIGIVGEGQ PFKIIEEADA QPYLNLLENE EPVEMQTN
Length:248
Mass (Da):27,988
Last modified:November 1, 1996 - v1
Checksum:i42C717B37BDA0F3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60168 Genomic DNA Translation: AAB03506.1
AAFI02000047 Genomic DNA Translation: EAL66041.1
RefSeqiXP_640037.1, XM_634945.1

Genome annotation databases

EnsemblProtistsiEAL66041; EAL66041; DDB_G0282363
GeneIDi8623563
KEGGiddi:DDB_G0282363

Entry informationi

Entry nameiPSA1_DICDI
AccessioniPrimary (citable) accession number: Q27562
Secondary accession number(s): Q54SK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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