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Protein

Acetyl-coenzyme A synthetase

Gene

ACS

Organism
Cryptosporidium parvum
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei347Coenzyme ABy similarity1
Binding sitei536ATPBy similarity1
Binding sitei551ATPBy similarity1
Binding sitei559Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei562ATPBy similarity1
Binding sitei628Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 425ATPBy similarity3
Nucleotide bindingi447 – 452ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:ACS
OrganismiCryptosporidium parvum
Taxonomic identifieri5807 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084101 – 694Acetyl-coenzyme A synthetaseAdd BLAST694

Interactioni

Protein-protein interaction databases

STRINGi353152.XP_628182.1.

Structurei

3D structure databases

ProteinModelPortaliQ27549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 232Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKRPRSPC SNNNDELNDS SVLTENMDTV ATRSKNLPFH ETYKSKPTPA
60 70 80 90 100
DKPYRVDGID KYKELYEQSI RDPEGFWSQM ARKELRWLRD FTKVRSSGTC
110 120 130 140 150
LQDRLAWFLN GKLNVCDNCV DRWAEIQPNT TALIWEGDDP SSIRHISYIE
160 170 180 190 200
LFRNVCKMAN VLKRFGIKKG DSVGIYMPMI PETIYTMLAC ARIGAVHMVV
210 220 230 240 250
FAGFAAQNLL ERLVNARCKI VVTADQGSRG KKIINLKDVV DKALEKIPEI
260 270 280 290 300
KTCIVFRHLN GPIEFVKGRD FDGETLMRSE KPYCPLEDMD SEDPLFYLYT
310 320 330 340 350
SGSTGTPKGV QHSTAGYLLY AAVTQKYLFN IHPGDIFGCA GDIGWITGHS
360 370 380 390 400
YLVYAPLCNG ITTLIFEGVP TYPNAGRYWE MVERHRITHF YAAPTAIRTL
410 420 430 440 450
KRLGDDFVKK HDRSSLRVLG SVGEPINPSA WRWYHSVVGE ERCSIVDTYW
460 470 480 490 500
QTETGGIVIA PIPGCFDTKP GSATFPFFGI EPAILDPDTG KEIDGPGSGV
510 520 530 540 550
LCIKNSWPGM FRGIFGAHYL HEIYTKPFPK YYFTGDGVLR DQDGYLWITG
560 570 580 590 600
RIDDTINVSG HRLSSKEIED ALTNHFGIAE AAAVAIDHDV KGNALVCFVV
610 620 630 640 650
LKDSGNRTFD LNNSSPHPFE YELRMCVRTQ IGPVATPDHI IVVENIPKTR
660 670 680 690
SGKVVRRLLR KIATGCNDYG DISTVANPEC IKSIESSWAQ YLKR
Length:694
Mass (Da):77,971
Last modified:November 1, 1996 - v1
Checksum:i5BA42E16E9AEE63C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24082 Genomic DNA. Translation: AAC47128.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24082 Genomic DNA. Translation: AAC47128.1.

3D structure databases

ProteinModelPortaliQ27549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353152.XP_628182.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSA_CRYPV
AccessioniPrimary (citable) accession number: Q27549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.