Reviewed, UniProtKB/Swiss-Prot Q27543 (K6PF_CALFI)

Names and origin

Protein names

Recommended name:
    6-phosphofructokinase
      Short name=Phosphofructokinase
    EC=2.7.1.11
Alternative name(s):
    Phosphohexokinase

Gene names

Name:

PFK

Organism

Calanus finmarchicus (Calanus tonsus)

Taxonomic identifier

6837 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Crustacea › Maxillopoda › Copepoda › Calanoida › Calanidae › Calanus

Protein attributes

Sequence length	184 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
Sequence similarities	Belongs to the phosphofructokinase family. Two domains subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphofructokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›184	›184	6-phosphofructokinase		PRO_0000112028
Regions
	Nucleotide binding	77 – 81	5	ATP By similarity
	Nucleotide binding	94 – 110	17	ATP By similarity
Sites
	Active site	50	1	Proton acceptor By similarity
	Binding site	85	1	Substrate By similarity
	Binding site	176	1	Substrate By similarity
	Binding site	182	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	184	1

Sequences

	Sequence		Length	Mass (Da)
	Q27543-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E9B71F095A5DF2AD	FASTA	184	20,208
	10 20 30 40 50 60 GGDGSLTGAN RFKGEWSSLV KELLETGKIT KEVAEKHSHL NIVGMVGSID NDFCGTDMTI 70 80 90 100 110 120 GTDSALHRIV EVADNIIPTA YSHQRAFVLE VMGRHCGYLA LVAGIVTEAD FVFAPEWPPE 130 140 150 160 170 180 EDWPEKLCKK LELERQSGQR LNIIIVAEGA IDRQGNPITA EGVKKIIVDR LEMDTRTTVL GHIQ

References

[1]	"Nuclear genes from the copepod Calanus finmarchicus." Crawford D.L. Mol. Mar. Biol. Biotechnol. 4:241-247(1995) [PubMed: 7670600] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U21244 mRNA. Translation: AAA85287.1.
3D structure databases
HSSP	HSSP built from PDB template 3PFK based on UniProtKB P00512.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.1.11. 297876.
Family and domain databases
InterPro	IPR000023. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. [Graphical view]
Pfam	PF00365. PFK. 1 hit. [Graphical view]
PRINTS	PR00476. PHFRCTKINASE.
ProDom	PD000707. Ppfruckinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00433. PHOSPHOFRUCTOKINASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

K6PF_CALFI

Accession

Primary (citable) accession number: Q27543

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)