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Protein

Superoxide dismutase [Cu-Zn]

Gene

sod-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sod-5Imported
ORF Names:CELE_ZK430.3Imported, ZK430.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK430.3; CE05080; WBGene00007036; sod-5.

PTM / Processingi

Proteomic databases

EPDiQ27538.
PaxDbiQ27538.
PRIDEiQ27538.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK430.3.

Structurei

3D structure databases

ProteinModelPortaliQ27538.
SMRiQ27538. Positions 22-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 172141Sod_CuInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
InParanoidiQ27538.
KOiK04565.
OMAiGAPEDEC.
OrthoDBiEOG776SR4.
PhylomeDBiQ27538.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDILSDIANA VLPQDVVSKV ESKRAVAVLR GTAVFGTVWL TQKAEGEETE
60 70 80 90 100
FEGEIKGLSP GLHGFHIHQY GDSTDGCTSA GPHFNPCKMN HGGRDSVVRH
110 120 130 140 150
VGDLGNVEAG ADGVAKIKFS DKVVSLFGAN TVIGRSMVVH VDRDDLGQGI
160 170
DDKAEESLKT GNAGARAACG VIALAAPA
Length:178
Mass (Da):18,507
Last modified:November 1, 1996 - v1
Checksum:i7A7D93D8E8DB5329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD61672.1.
PIRiJE0098.
T27860.
RefSeqiNP_494779.1. NM_062378.3.
UniGeneiCel.13783.

Genome annotation databases

EnsemblMetazoaiZK430.3; ZK430.3; WBGene00007036.
GeneIDi173776.
KEGGicel:CELE_ZK430.3.
UCSCiZK430.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD61672.1.
PIRiJE0098.
T27860.
RefSeqiNP_494779.1. NM_062378.3.
UniGeneiCel.13783.

3D structure databases

ProteinModelPortaliQ27538.
SMRiQ27538. Positions 22-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK430.3.

Proteomic databases

EPDiQ27538.
PaxDbiQ27538.
PRIDEiQ27538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK430.3; ZK430.3; WBGene00007036.
GeneIDi173776.
KEGGicel:CELE_ZK430.3.
UCSCiZK430.3. c. elegans.

Organism-specific databases

CTDi173776.
WormBaseiZK430.3; CE05080; WBGene00007036; sod-5.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
InParanoidiQ27538.
KOiK04565.
OMAiGAPEDEC.
OrthoDBiEOG776SR4.
PhylomeDBiQ27538.

Miscellaneous databases

NextBioi881049.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27538_CAEEL
AccessioniPrimary (citable) accession number: Q27538
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.