ID   GALT_CAEEL              Reviewed;         352 AA.
AC   Q27536;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Probable galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   ORFNames=ZK1058.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: UDP-glucose + alpha-D-galactose 1-phosphate =
CC       alpha-D-glucose 1-phosphate + UDP-galactose.
CC   -!- COFACTOR: Binds 1 iron ion per subunit (Potential).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (Potential).
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate
CC       uridylyltransferase type 1 family.
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DR   EMBL; Z35604; CAA84679.1; -; Genomic_DNA.
DR   PIR; T27677; T27677.
DR   RefSeq; NP_497789.1; -.
DR   UniGene; Cel.9506; -.
DR   HSSP; P09148; 1HXQ.
DR   Ensembl; ZK1058.3; Caenorhabditis elegans.
DR   GeneID; 175506; -.
DR   KEGG; cel:ZK1058.3; -.
DR   NMPDR; fig|6239.3.peg.9256; -.
DR   WormBase; WBGene00014203; ZK1058.3.
DR   WormPep; ZK1058.3; CE01103.
DR   OMA; Q27536; DHWQLHA.
DR   BRENDA; 2.7.7.12; 672.
DR   NextBio; 888452; -.
DR   ArrayExpress; Q27536; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltran...; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001937; GalP_UDPtransf1.
DR   InterPro; IPR019779; GalP_UDPtransf1_His-AS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   InterPro; IPR011151; His_triad_motif.
DR   Gene3D; G3DSA:3.30.428.10; His_triad_motif; 2.
DR   PANTHER; PTHR11943; GalP_UDPtransf1; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF000808; GalT; 1.
DR   ProDom; PD005051; GalP_Utransf; 2.
DR   TIGRFAMs; TIGR00209; galT_1; 1.
DR   PROSITE; PS00117; GAL_P_UDP_TRANSF_I; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Complete proteome; Galactose metabolism;
KW   Iron; Metal-binding; Nucleotidyltransferase; Transferase; Zinc.
FT   CHAIN         1    352       Probable galactose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000169885.
FT   ACT_SITE    167    167       Tele-UMP-histidine intermediate (By
FT                                similarity).
FT   METAL       165    165       Zinc (Potential).
FT   METAL       300    300       Iron (Potential).
SQ   SEQUENCE   352 AA;  41043 MW;  F1B433A926C47C4C CRC64;
     MSKQNNFRRY NPLIDEWVIV AVNRINRPWQ GAKTEKSTTI STSSNTEQSI LNPLAPGGTR
     SSGIANENYV STYVFDNDFP SFTEFEECAG KDENDDLFKQ HEVKGVCKVI CYHPNSQLTL
     ATMDVKEVRV VIDIWNQQYL ELGPKYEWVQ IFENRGAVVG CSNMHPHGQL WASNYLPTLP
     MKKHESQKKH FEKHGKVMLM DYLEQETLKK ERIIMRNEHW TWLVPYWAFW PYETMLLPNR
     HVERFTDLGE VEKQSLSEIL RSLLIKYDNV FECSFPYMMG WSGAPTGSFL TENCSFWQLH
     LSFFPPLLRS ATVPKFLAGY EVFAEKQRDL SPEIAAKTLS EIDEEHYSKK LQ
//