Reviewed, UniProtKB/Swiss-Prot Q27536 (GALT_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

ORF Names:

ZK1058.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit Potential. Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Probable galactose-1-phosphate uridylyltransferase		PRO_0000169885
Sites
	Active site	167	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	165	1	Zinc Potential
	Metal binding	300	1	Iron Potential

Sequences

	Sequence		Length	Mass (Da)
	Q27536-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F1B433A926C47C4C	FASTA	352	41,043
	10 20 30 40 50 60 MSKQNNFRRY NPLIDEWVIV AVNRINRPWQ GAKTEKSTTI STSSNTEQSI LNPLAPGGTR 70 80 90 100 110 120 SSGIANENYV STYVFDNDFP SFTEFEECAG KDENDDLFKQ HEVKGVCKVI CYHPNSQLTL 130 140 150 160 170 180 ATMDVKEVRV VIDIWNQQYL ELGPKYEWVQ IFENRGAVVG CSNMHPHGQL WASNYLPTLP 190 200 210 220 230 240 MKKHESQKKH FEKHGKVMLM DYLEQETLKK ERIIMRNEHW TWLVPYWAFW PYETMLLPNR 250 260 270 280 290 300 HVERFTDLGE VEKQSLSEIL RSLLIKYDNV FECSFPYMMG WSGAPTGSFL TENCSFWQLH 310 320 330 340 350 LSFFPPLLRS ATVPKFLAGY EVFAEKQRDL SPEIAAKTLS EIDEEHYSKK LQ

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z35604 Genomic DNA. Translation: CAA84679.1.
PIR	T27677.
RefSeq	NP_497789.1.
UniGene	Cel.9506
3D structure databases
SMR	Q27536. Positions 5-350.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q27536. 1 interaction.
STRING	Q27536.
Genome annotation databases
Ensembl	ZK1058.3; ZK1058.3; ZK1058.3; Caenorhabditis elegans. [Genome view]
GeneID	175506.
KEGG	cel:ZK1058.3.
NMPDR	fig|6239.3.peg.9256.
UCSC	ZK1058.3. c. elegans.
Organism-specific databases
CTD	175506.
WormBase	WBGene00014203. ZK1058.3.
WormPep	ZK1058.3. CE01103. [WorfDB]
Phylogenomic databases
eggNOG	meNOG05737.
HOGENOM	HBG600409.
InParanoid	Q27536.
OMA	DHWQLHA.
PhylomeDB	Q27536.
Enzyme and pathway databases
BRENDA	2.7.7.12. 672.
Gene expression databases
ArrayExpress	Q27536.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	888452.

Entry information

Entry name

GALT_CAEEL

Accession

Primary (citable) accession number: Q27536

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project