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Protein

Probable arginine kinase ZC434.8

Gene

ZC434.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei189ATPPROSITE-ProRule annotation1
Binding sitei229SubstrateBy similarity1
Binding sitei233ATPPROSITE-ProRule annotation1
Binding sitei275SubstrateBy similarity1
Binding sitei317SubstrateBy similarity1
Binding sitei327ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 129ATPPROSITE-ProRule annotation5
Nucleotide bindingi284 – 288ATPPROSITE-ProRule annotation5
Nucleotide bindingi312 – 317ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-71288. Creatine metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine kinase ZC434.8 (EC:2.7.3.3)
Short name:
AK
Gene namesi
ORF Names:ZC434.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZC434.8; CE06583; WBGene00013894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119891 – 360Probable arginine kinase ZC434.8Add BLAST360

Proteomic databases

EPDiQ27535.
PaxDbiQ27535.
PeptideAtlasiQ27535.
PRIDEiQ27535.

PTM databases

iPTMnetiQ27535.

Expressioni

Gene expression databases

BgeeiWBGene00013894.

Interactioni

Protein-protein interaction databases

BioGridi38324. 6 interactors.
DIPiDIP-25633N.
IntActiQ27535. 1 interactor.
MINTiMINT-1047932.
STRINGi6239.ZC434.8.2.

Structurei

3D structure databases

ProteinModelPortaliQ27535.
SMRiQ27535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 92Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini122 – 359Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 69Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3581. Eukaryota.
COG3869. LUCA.
GeneTreeiENSGT00550000074561.
HOGENOMiHOG000232165.
InParanoidiQ27535.
KOiK00933.
OMAiTNYKMME.
OrthoDBiEOG091G0HZ0.
PhylomeDBiQ27535.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiView protein in InterPro
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR036802. ATP-guanido_PTrfase_N_sf.
IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiView protein in Pfam
PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
SUPFAMiSSF48034. SSF48034. 1 hit.
SSF55931. SSF55931. 1 hit.
PROSITEiView protein in PROSITE
PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATPEVQKS IEEVYTKLQG ASDCSSLLKK HLTKDVVAKN KSKKTRLGAT
60 70 80 90 100
LLDVIQSGGE NLDSGVGIYA PDAESYTLFA DLFNPVIEEY HNGFKATDTQ
110 120 130 140 150
PAMDLGEKNV GELADLDPEG KFIVSTRIRC GRSLQGYPFN PCLSETNYKM
160 170 180 190 200
METRMKEIFN SITDPELKGT YYPLTGMDEE TKKKLIADHF LFKEGDRFLK
210 220 230 240 250
AANANRYWPN GRGIFHNEKK TFLVWVNEED HLRIISMQNG GNVGEVLARL
260 270 280 290 300
IKGLNLVAAK APFARHPRLG WLTFCPTNLG TTVRASVHIK LPKISAKDDF
310 320 330 340 350
KKICSDMKLQ IRGIHGEHSE SKEGIYDISN KQRLGLTEYQ AVRQMYDGLK
360
KLIELEKAAA
Length:360
Mass (Da):40,382
Last modified:November 1, 1996 - v1
Checksum:i176760B381EF26D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75714 Genomic DNA. Translation: CAB00062.1.
PIRiT27569.
RefSeqiNP_492714.1. NM_060313.7.
UniGeneiCel.7229.

Genome annotation databases

EnsemblMetazoaiZC434.8.1; ZC434.8.1; WBGene00013894.
ZC434.8.2; ZC434.8.2; WBGene00013894.
GeneIDi172907.
KEGGicel:CELE_ZC434.8.
UCSCiZC434.8.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiKARG2_CAEEL
AccessioniPrimary (citable) accession number: Q27535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families