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Protein

Probable cation-transporting ATPase W08D2.5

Gene

W08D2.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 46514-aspartylphosphate intermediateBy similarity
Metal bindingi880 – 8801MagnesiumBy similarity
Metal bindingi884 – 8841MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: InterPro
  • protein folding Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase W08D2.5 (EC:3.6.3.-)
Gene namesi
ORF Names:W08D2.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiW08D2.5a; CE32950; WBGene00012341; catp-6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 178136CytoplasmicSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 2067ExtracellularSequence analysis
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 379152CytoplasmicSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 41313ExtracellularSequence analysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence analysisAdd
BLAST
Topological domaini435 – 939505CytoplasmicSequence analysisAdd
BLAST
Transmembranei940 – 96021HelicalSequence analysisAdd
BLAST
Topological domaini961 – 9655ExtracellularSequence analysis
Transmembranei966 – 98621HelicalSequence analysisAdd
BLAST
Topological domaini987 – 100216CytoplasmicSequence analysisAdd
BLAST
Transmembranei1003 – 102321HelicalSequence analysisAdd
BLAST
Topological domaini1024 – 104724ExtracellularSequence analysisAdd
BLAST
Transmembranei1048 – 106821HelicalSequence analysisAdd
BLAST
Topological domaini1069 – 108618CytoplasmicSequence analysisAdd
BLAST
Transmembranei1087 – 110721HelicalSequence analysisAdd
BLAST
Topological domaini1108 – 112114ExtracellularSequence analysisAdd
BLAST
Transmembranei1122 – 114221HelicalSequence analysisAdd
BLAST
Topological domaini1143 – 1256114CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: WormBase
  • vacuolar membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12561256Probable cation-transporting ATPase W08D2.5PRO_0000046358Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ27533.
PaxDbiQ27533.

Expressioni

Gene expression databases

ExpressionAtlasiQ27533. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ27533. 1 interaction.
MINTiMINT-3384237.
STRINGi6239.W08D2.5a.

Structurei

3D structure databases

ProteinModelPortaliQ27533.
SMRiQ27533. Positions 142-963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
InParanoidiQ27533.
KOiK14951.
OMAiCAYLYET.
PhylomeDBiQ27533.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLESGDHTL TLFAYRTGPF RTILFYALTV LTLGIFRLIL HWKQKWDVKM
60 70 80 90 100
RMVPCTFEAA EYIYIIDNHN VSELQPVLRK SNATIPTENG EMRKVPELRW
110 120 130 140 150
FVYRKLEYVW IDDLNSDESV DEISDNDNCW KTSFEIANRI PCRSLLAVSE
160 170 180 190 200
SNFGLTLSEI SRRLEFYGRN EIVVQLRPIL YLLVMEVITP FYVFQIFSVT
210 220 230 240 250
VWYNDEYAYY ASLIVILSLG SIVMDVYQIR TQEIRLRSMV HSTESVEVIR
260 270 280 290 300
EGTEMTIGSD QLVPGDILLI PPHGCLMQCD SVLMNGTVIV NESVLTGESV
310 320 330 340 350
PITKVALTDE TNDSVFNIEK NSKNVLFCGT QVLQTRFYRG KKVKAIVLRT
360 370 380 390 400
AYSTLKGQLV RSIMYPKPVD FRFTKDLFKF ILFLACISGC GFIYTIIVMI
410 420 430 440 450
MRGNTLRRII VRSLDIITIT VPPALPAAMS VGIINAQLRL KKKEIFCISP
460 470 480 490 500
STINTCGAIN VVCFDKTGTL TEDGLDFHVV RPVMSAVNQE IQKVKLEKSN
510 520 530 540 550
RTEFMGEMTE LTSRNGLPFD GDLVKAIATC HSLTRINGVL HGDPLDLILF
560 570 580 590 600
QKTGWTMEEG IEGDIEEETQ RFDNVQPSII KPTDDKSAEY SVIRQFTFSS
610 620 630 640 650
SLQRMSVIVF DPREDRPDNM MLYSKGSPEM ILSLCDPNTV PEDYLLQVNS
660 670 680 690 700
YAQHGFRLIA VARRPLDLNF NKASKVKRDA VECDLEMLGL IVMENRVKPV
710 720 730 740 750
TLGVINQLNR ANIRTVMVTG DNLLTGLSVA RECGIIRPSK RAFLVEHVPG
760 770 780 790 800
ELDEYGRTKI FVKQSVSSSD EVIEDDASVS ISMCSSTWKG SSEGDGFSPT
810 820 830 840 850
NTEVETPNPV TADSLGHLIA SSYHLAISGP TFAVIVHEYP ELVDQLCSVC
860 870 880 890 900
DVFARMAPDQ KQSLVEQLQQ IDYTVAMCGD GANDCAALKA AHAGISLSDA
910 920 930 940 950
EASIAAPFTS KVPDIRCVPT VISEGRAALV TSFGIFKYMA GYSLTQFVTV
960 970 980 990 1000
MHLYWISNIL TDGQFMYIDM FLITMFALLF GNTPAFYRLA HTPPPTRLLS
1010 1020 1030 1040 1050
IASMTSVVGQ LIIIGVVQFI VFFSTSQQPW FTPYQPPVDD EVEDKRSMQG
1060 1070 1080 1090 1100
TALFCVSMFQ YIILALVYSK GPPFRGNLWS NKPMCALTIF ATLLCLFIVI
1110 1120 1130 1140 1150
WPTELVLKTL GNVELPSLTF RIFIVIVGAV NAAVSYGFET LFVDFFLLGY
1160 1170 1180 1190 1200
WERYKKKRSI EAIIDYVPTT NSDHIRRPSI NGVTSSRTES TLLSAEGQQL
1210 1220 1230 1240 1250
HMTTSKNGKG GENPHSSALF ERLISRIGGE PTWLTNPIPP HSLSEPEEPE

KLERTY
Length:1,256
Mass (Da):140,902
Last modified:May 9, 2003 - v2
Checksum:iCC2DE9F6AE3AECA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70271 Genomic DNA. Translation: CAA94236.2.
PIRiT26283.
RefSeqiNP_001255430.1. NM_001268501.1.
UniGeneiCel.38726.

Genome annotation databases

EnsemblMetazoaiW08D2.5a; W08D2.5a; WBGene00012341.
GeneIDi177822.
KEGGicel:CELE_W08D2.5.
UCSCiW08D2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70271 Genomic DNA. Translation: CAA94236.2.
PIRiT26283.
RefSeqiNP_001255430.1. NM_001268501.1.
UniGeneiCel.38726.

3D structure databases

ProteinModelPortaliQ27533.
SMRiQ27533. Positions 142-963.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ27533. 1 interaction.
MINTiMINT-3384237.
STRINGi6239.W08D2.5a.

Proteomic databases

EPDiQ27533.
PaxDbiQ27533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW08D2.5a; W08D2.5a; WBGene00012341.
GeneIDi177822.
KEGGicel:CELE_W08D2.5.
UCSCiW08D2.5. c. elegans.

Organism-specific databases

CTDi177822.
WormBaseiW08D2.5a; CE32950; WBGene00012341; catp-6.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
InParanoidiQ27533.
KOiK14951.
OMAiCAYLYET.
PhylomeDBiQ27533.

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ27533.

Gene expression databases

ExpressionAtlasiQ27533. baseline.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYH2M_CAEEL
AccessioniPrimary (citable) accession number: Q27533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 9, 2003
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.