Probable cation-transporting ATPase W08D2.5

Preferred order of sections

Names and origin

Protein names

Recommended name:
Probable cation-transporting ATPase W08D2.5
EC=3.6.3.-

Gene names

ORF Names:

W08D2.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1256 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro protein folding Inferred from genetic interaction. Source: WormBase
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1256

1256

Probable cation-transporting ATPase W08D2.5

PRO_0000046358

Regions

Topological domain

1 – 21

21

Extracellular Potential

Transmembrane

22 – 42

21

Helical; Potential

Topological domain

43 – 178

136

Cytoplasmic Potential

Transmembrane

179 – 199

21

Helical; Potential

Topological domain

200 – 206

7

Extracellular Potential

Transmembrane

207 – 227

21

Helical; Potential

Topological domain

228 – 379

152

Cytoplasmic Potential

Transmembrane

380 – 400

21

Helical; Potential

Topological domain

401 – 413

13

Extracellular Potential

Transmembrane

414 – 434

21

Helical; Potential

Topological domain

435 – 939

505

Cytoplasmic Potential

Transmembrane

940 – 960

21

Helical; Potential

Topological domain

961 – 965

5

Extracellular Potential

Transmembrane

966 – 986

21

Helical; Potential

Topological domain

987 – 1002

16

Cytoplasmic Potential

Transmembrane

1003 – 1023

21

Helical; Potential

Topological domain

1024 – 1047

24

Extracellular Potential

Transmembrane

1048 – 1068

21

Helical; Potential

Topological domain

1069 – 1086

18

Cytoplasmic Potential

Transmembrane

1087 – 1107

21

Helical; Potential

Topological domain

1108 – 1121

14

Extracellular Potential

Transmembrane

1122 – 1142

21

Helical; Potential

Topological domain

1143 – 1256

114

Cytoplasmic Potential

Sites

Active site

465

1

4-aspartylphosphate intermediate By similarity

Metal binding

880

1

Magnesium By similarity

Metal binding

884

1

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q27533 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: CC2DE9F6AE3AECA3
Show »

FASTA

1,256

140,902

        10         20         30         40         50         60 
MTLESGDHTL TLFAYRTGPF RTILFYALTV LTLGIFRLIL HWKQKWDVKM RMVPCTFEAA 

        70         80         90        100        110        120 
EYIYIIDNHN VSELQPVLRK SNATIPTENG EMRKVPELRW FVYRKLEYVW IDDLNSDESV 

       130        140        150        160        170        180 
DEISDNDNCW KTSFEIANRI PCRSLLAVSE SNFGLTLSEI SRRLEFYGRN EIVVQLRPIL 

       190        200        210        220        230        240 
YLLVMEVITP FYVFQIFSVT VWYNDEYAYY ASLIVILSLG SIVMDVYQIR TQEIRLRSMV 

       250        260        270        280        290        300 
HSTESVEVIR EGTEMTIGSD QLVPGDILLI PPHGCLMQCD SVLMNGTVIV NESVLTGESV 

       310        320        330        340        350        360 
PITKVALTDE TNDSVFNIEK NSKNVLFCGT QVLQTRFYRG KKVKAIVLRT AYSTLKGQLV 

       370        380        390        400        410        420 
RSIMYPKPVD FRFTKDLFKF ILFLACISGC GFIYTIIVMI MRGNTLRRII VRSLDIITIT 

       430        440        450        460        470        480 
VPPALPAAMS VGIINAQLRL KKKEIFCISP STINTCGAIN VVCFDKTGTL TEDGLDFHVV 

       490        500        510        520        530        540 
RPVMSAVNQE IQKVKLEKSN RTEFMGEMTE LTSRNGLPFD GDLVKAIATC HSLTRINGVL 

       550        560        570        580        590        600 
HGDPLDLILF QKTGWTMEEG IEGDIEEETQ RFDNVQPSII KPTDDKSAEY SVIRQFTFSS 

       610        620        630        640        650        660 
SLQRMSVIVF DPREDRPDNM MLYSKGSPEM ILSLCDPNTV PEDYLLQVNS YAQHGFRLIA 

       670        680        690        700        710        720 
VARRPLDLNF NKASKVKRDA VECDLEMLGL IVMENRVKPV TLGVINQLNR ANIRTVMVTG 

       730        740        750        760        770        780 
DNLLTGLSVA RECGIIRPSK RAFLVEHVPG ELDEYGRTKI FVKQSVSSSD EVIEDDASVS 

       790        800        810        820        830        840 
ISMCSSTWKG SSEGDGFSPT NTEVETPNPV TADSLGHLIA SSYHLAISGP TFAVIVHEYP 

       850        860        870        880        890        900 
ELVDQLCSVC DVFARMAPDQ KQSLVEQLQQ IDYTVAMCGD GANDCAALKA AHAGISLSDA 

       910        920        930        940        950        960 
EASIAAPFTS KVPDIRCVPT VISEGRAALV TSFGIFKYMA GYSLTQFVTV MHLYWISNIL 

       970        980        990       1000       1010       1020 
TDGQFMYIDM FLITMFALLF GNTPAFYRLA HTPPPTRLLS IASMTSVVGQ LIIIGVVQFI 

      1030       1040       1050       1060       1070       1080 
VFFSTSQQPW FTPYQPPVDD EVEDKRSMQG TALFCVSMFQ YIILALVYSK GPPFRGNLWS 

      1090       1100       1110       1120       1130       1140 
NKPMCALTIF ATLLCLFIVI WPTELVLKTL GNVELPSLTF RIFIVIVGAV NAAVSYGFET 

      1150       1160       1170       1180       1190       1200 
LFVDFFLLGY WERYKKKRSI EAIIDYVPTT NSDHIRRPSI NGVTSSRTES TLLSAEGQQL 

      1210       1220       1230       1240       1250 
HMTTSKNGKG GENPHSSALF ERLISRIGGE PTWLTNPIPP HSLSEPEEPE KLERTY

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References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z70271 Genomic DNA. Translation: CAA94236.2.
PIR	T26283.
RefSeq	NP_501755.2. NM_069354.4.
UniGene	Cel.5201.
3D structure databases
ProteinModelPortal	Q27533.
SMR	Q27533. Positions 232-365, 860-923.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-3384237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	W08D2.5a; W08D2.5a; W08D2.5.
GeneID	177822.
KEGG	cel:W08D2.5.
NMPDR	fig\|6239.3.peg.14673.
UCSC	W08D2.5. c. elegans.
Organism-specific databases
CTD	177822.
WormBase	W08D2.5a; CE32950; WBGene00012341; catp-6.
Phylogenomic databases
eggNOG	meNOG06533.
GeneTree	EMGT00070000025723.
HOGENOM	HBG735026.
InParanoid	Q27533.
OMA	VTCHSIT.
PhylomeDB	Q27533.
Gene expression databases
ArrayExpress	Q27533.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006544. ATPase_P-typ_unknown-pump-sp. IPR023214. HAD-like_dom. IPR000150. Hypothet_cof. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K14951.
Pfam	PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01494. ATPase_P-type. 2 hits. TIGR01657. P-ATPase-V. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	898530.

Entry information

Entry name

YH2M_CAEEL

Accession

Primary (citable) accession number: Q27533

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 9, 2003
Last modified:	December 14, 2011
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents