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Protein

Probable cation-transporting ATPase W08D2.5

Gene

W08D2.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4654-aspartylphosphate intermediateBy similarity1
Metal bindingi880MagnesiumBy similarity1
Metal bindingi884MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: GO_Central
  • protein folding Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase W08D2.5 (EC:3.6.3.-)
Gene namesi
ORF Names:W08D2.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiW08D2.5a; CE32950; WBGene00012341; catp-6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 178CytoplasmicSequence analysisAdd BLAST136
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 206ExtracellularSequence analysis7
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 379CytoplasmicSequence analysisAdd BLAST152
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 413ExtracellularSequence analysisAdd BLAST13
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 939CytoplasmicSequence analysisAdd BLAST505
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 965ExtracellularSequence analysis5
Transmembranei966 – 986HelicalSequence analysisAdd BLAST21
Topological domaini987 – 1002CytoplasmicSequence analysisAdd BLAST16
Transmembranei1003 – 1023HelicalSequence analysisAdd BLAST21
Topological domaini1024 – 1047ExtracellularSequence analysisAdd BLAST24
Transmembranei1048 – 1068HelicalSequence analysisAdd BLAST21
Topological domaini1069 – 1086CytoplasmicSequence analysisAdd BLAST18
Transmembranei1087 – 1107HelicalSequence analysisAdd BLAST21
Topological domaini1108 – 1121ExtracellularSequence analysisAdd BLAST14
Transmembranei1122 – 1142HelicalSequence analysisAdd BLAST21
Topological domaini1143 – 1256CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: WormBase
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: WormBase
  • vacuolar membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463581 – 1256Probable cation-transporting ATPase W08D2.5Add BLAST1256

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ27533.
PaxDbiQ27533.
PRIDEiQ27533.

Expressioni

Gene expression databases

BgeeiWBGene00012341.
ExpressionAtlasiQ27533. differential.

Interactioni

Protein-protein interaction databases

IntActiQ27533. 1 interactor.
MINTiMINT-3384237.
STRINGi6239.W08D2.5a.

Structurei

3D structure databases

ProteinModelPortaliQ27533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
InParanoidiQ27533.
KOiK14951.
OMAiPMCALTI.
OrthoDBiEOG091G01IL.
PhylomeDBiQ27533.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLESGDHTL TLFAYRTGPF RTILFYALTV LTLGIFRLIL HWKQKWDVKM
60 70 80 90 100
RMVPCTFEAA EYIYIIDNHN VSELQPVLRK SNATIPTENG EMRKVPELRW
110 120 130 140 150
FVYRKLEYVW IDDLNSDESV DEISDNDNCW KTSFEIANRI PCRSLLAVSE
160 170 180 190 200
SNFGLTLSEI SRRLEFYGRN EIVVQLRPIL YLLVMEVITP FYVFQIFSVT
210 220 230 240 250
VWYNDEYAYY ASLIVILSLG SIVMDVYQIR TQEIRLRSMV HSTESVEVIR
260 270 280 290 300
EGTEMTIGSD QLVPGDILLI PPHGCLMQCD SVLMNGTVIV NESVLTGESV
310 320 330 340 350
PITKVALTDE TNDSVFNIEK NSKNVLFCGT QVLQTRFYRG KKVKAIVLRT
360 370 380 390 400
AYSTLKGQLV RSIMYPKPVD FRFTKDLFKF ILFLACISGC GFIYTIIVMI
410 420 430 440 450
MRGNTLRRII VRSLDIITIT VPPALPAAMS VGIINAQLRL KKKEIFCISP
460 470 480 490 500
STINTCGAIN VVCFDKTGTL TEDGLDFHVV RPVMSAVNQE IQKVKLEKSN
510 520 530 540 550
RTEFMGEMTE LTSRNGLPFD GDLVKAIATC HSLTRINGVL HGDPLDLILF
560 570 580 590 600
QKTGWTMEEG IEGDIEEETQ RFDNVQPSII KPTDDKSAEY SVIRQFTFSS
610 620 630 640 650
SLQRMSVIVF DPREDRPDNM MLYSKGSPEM ILSLCDPNTV PEDYLLQVNS
660 670 680 690 700
YAQHGFRLIA VARRPLDLNF NKASKVKRDA VECDLEMLGL IVMENRVKPV
710 720 730 740 750
TLGVINQLNR ANIRTVMVTG DNLLTGLSVA RECGIIRPSK RAFLVEHVPG
760 770 780 790 800
ELDEYGRTKI FVKQSVSSSD EVIEDDASVS ISMCSSTWKG SSEGDGFSPT
810 820 830 840 850
NTEVETPNPV TADSLGHLIA SSYHLAISGP TFAVIVHEYP ELVDQLCSVC
860 870 880 890 900
DVFARMAPDQ KQSLVEQLQQ IDYTVAMCGD GANDCAALKA AHAGISLSDA
910 920 930 940 950
EASIAAPFTS KVPDIRCVPT VISEGRAALV TSFGIFKYMA GYSLTQFVTV
960 970 980 990 1000
MHLYWISNIL TDGQFMYIDM FLITMFALLF GNTPAFYRLA HTPPPTRLLS
1010 1020 1030 1040 1050
IASMTSVVGQ LIIIGVVQFI VFFSTSQQPW FTPYQPPVDD EVEDKRSMQG
1060 1070 1080 1090 1100
TALFCVSMFQ YIILALVYSK GPPFRGNLWS NKPMCALTIF ATLLCLFIVI
1110 1120 1130 1140 1150
WPTELVLKTL GNVELPSLTF RIFIVIVGAV NAAVSYGFET LFVDFFLLGY
1160 1170 1180 1190 1200
WERYKKKRSI EAIIDYVPTT NSDHIRRPSI NGVTSSRTES TLLSAEGQQL
1210 1220 1230 1240 1250
HMTTSKNGKG GENPHSSALF ERLISRIGGE PTWLTNPIPP HSLSEPEEPE

KLERTY
Length:1,256
Mass (Da):140,902
Last modified:May 9, 2003 - v2
Checksum:iCC2DE9F6AE3AECA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70271 Genomic DNA. Translation: CAA94236.2.
PIRiT26283.
RefSeqiNP_001255430.1. NM_001268501.1.
UniGeneiCel.38726.

Genome annotation databases

EnsemblMetazoaiW08D2.5a; W08D2.5a; WBGene00012341.
GeneIDi177822.
KEGGicel:CELE_W08D2.5.
UCSCiW08D2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70271 Genomic DNA. Translation: CAA94236.2.
PIRiT26283.
RefSeqiNP_001255430.1. NM_001268501.1.
UniGeneiCel.38726.

3D structure databases

ProteinModelPortaliQ27533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ27533. 1 interactor.
MINTiMINT-3384237.
STRINGi6239.W08D2.5a.

Proteomic databases

EPDiQ27533.
PaxDbiQ27533.
PRIDEiQ27533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW08D2.5a; W08D2.5a; WBGene00012341.
GeneIDi177822.
KEGGicel:CELE_W08D2.5.
UCSCiW08D2.5. c. elegans.

Organism-specific databases

CTDi177822.
WormBaseiW08D2.5a; CE32950; WBGene00012341; catp-6.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
InParanoidiQ27533.
KOiK14951.
OMAiPMCALTI.
OrthoDBiEOG091G01IL.
PhylomeDBiQ27533.

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ27533.

Gene expression databases

BgeeiWBGene00012341.
ExpressionAtlasiQ27533. differential.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYH2M_CAEEL
AccessioniPrimary (citable) accession number: Q27533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 9, 2003
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.