Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone H3.3-like type 2

Gene

his-74

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3.3-like type 2
Gene namesi
Name:his-74
ORF Names:W05B10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiW05B10.1; CE06544; WBGene00012276; his-74.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002686342 – 136Histone H3.3-like type 2Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysine; alternateBy similarity1
Modified residuei5N6-methylated lysine; alternateBy similarity1
Modified residuei10N6-acetyllysine; alternateBy similarity1
Modified residuei10N6-methylated lysine; alternateBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Modified residuei37N6-methylated lysineBy similarity1
Modified residuei80N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity
Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ27532.
PaxDbiQ27532.
PeptideAtlasiQ27532.
PRIDEiQ27532.

Expressioni

Gene expression databases

BgeeiWBGene00012276.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi44754. 1 interactor.
DIPiDIP-24615N.
MINTiMINT-1043969.
STRINGi6239.W05B10.1.

Structurei

3D structure databases

ProteinModelPortaliQ27532.
SMRiQ27532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27532.
KOiK11253.
OMAiKPHRFRK.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27532.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00959. HISTONE_H3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKQTARK STGGKAPRKA LATKAARKSA IVTGSVKKVH RFRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLLRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDMQLARR IRGERS
Length:136
Mass (Da):15,349
Last modified:January 23, 2007 - v3
Checksum:iD93AECF349E14D2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74476 Genomic DNA. Translation: CAA98963.1.
PIRiT26178.
RefSeqiNP_506164.1. NM_073763.4.
UniGeneiCel.2018.

Genome annotation databases

EnsemblMetazoaiW05B10.1; W05B10.1; WBGene00012276.
GeneIDi179734.
KEGGicel:CELE_W05B10.1.
UCSCiW05B10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74476 Genomic DNA. Translation: CAA98963.1.
PIRiT26178.
RefSeqiNP_506164.1. NM_073763.4.
UniGeneiCel.2018.

3D structure databases

ProteinModelPortaliQ27532.
SMRiQ27532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44754. 1 interactor.
DIPiDIP-24615N.
MINTiMINT-1043969.
STRINGi6239.W05B10.1.

Proteomic databases

EPDiQ27532.
PaxDbiQ27532.
PeptideAtlasiQ27532.
PRIDEiQ27532.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW05B10.1; W05B10.1; WBGene00012276.
GeneIDi179734.
KEGGicel:CELE_W05B10.1.
UCSCiW05B10.1. c. elegans.

Organism-specific databases

CTDi179734.
WormBaseiW05B10.1; CE06544; WBGene00012276; his-74.

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27532.
KOiK11253.
OMAiKPHRFRK.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27532.

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ27532.

Gene expression databases

BgeeiWBGene00012276.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00959. HISTONE_H3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH33L2_CAEEL
AccessioniPrimary (citable) accession number: Q27532
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.