Reviewed, UniProtKB/Swiss-Prot Q27518 (C13A2_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative cytochrome P450 CYP13A2
    EC=1.14.-.-

Gene names

Name:	cyp-13A2
Synonyms:	cyp13a2
ORF Names:	T10B9.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Putative cytochrome P450 CYP13A2		PRO_0000052262
Sites
	Metal binding	460	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27518-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 38942AC8E3617F98	FASTA	515	59,232
	10 20 30 40 50 60 MSLGFVLAVT FSIFLGILTY YLWIWTYWMR KGVKGPRGRP FVGVLDVLLE HETPGLIKLG 70 80 90 100 110 120 EWTKKYGKVY GYTDGTQRTL VVADPAMVHE IFVKQFDNFY GRKLNPIQGN PEKEQRVHLL 130 140 150 160 170 180 AAQGYRWKRL RTISSQSFSN ASLKKMKRTV EDSALELLRH IEKQTAGGEQ IDMLRFYQEY 190 200 210 220 230 240 TMDVIGRFAM GQTDSMMFKN PIVNVVREIF CGSRKNLMLI CQVFPPIGQF IRDLTFKFPR 250 260 270 280 290 300 IPAFKLYSIM QDVVAARIAQ REREKGAESG EPQDFIDLFL DARSDDVDFS AEAREDFSKR 310 320 330 340 350 360 NLKITKELSA DEVVGQCFLF LIGGFDTTAL SLSYVTYLLA VNPKIQEKVI EEIAREFGTS 370 380 390 400 410 420 EVEFEKLGRL KYMDCVIKEA LRLYPLASIS NSRKCMKTTT VNGVKIEAGV YVQMDTWSLH 430 440 450 460 470 480 YDPELWGEDV KEFKPERWST DEPLEHKGAY LPFGLGPRQC IGMRLAIMEQ KILLTHLLKN 490 500 510 YTFETGNKTR IPLKLVGSAT TSPEDVFVHL RPRIW

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z48717 Genomic DNA. Translation: CAA88607.1.
PIR	T24781.
RefSeq	NP_496109.1.
UniGene	Cel.14402
3D structure databases
HSSP	HSSP built from PDB template 1JME based on UniProtKB P14779.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25672N.
IntAct	Q27518. 1 interaction.
Genome annotation databases
Ensembl	T10B9.7. Caenorhabditis elegans. [Contig view]
GeneID	188360.
KEGG	cel:T10B9.7.
NMPDR	fig|6239.3.peg.7037.
Organism-specific databases
WormBase	WBGene00011676. cyp-13A2.
WormPep	T10B9.7. CE01659. [WorfDB]
Gene expression databases
ArrayExpress	Q27518.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	938514.

Entry information

Entry name

C13A2_CAEEL

Accession

Primary (citable) accession number: Q27518

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project