Reviewed, UniProtKB/Swiss-Prot Q27516 (C13A8_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative cytochrome P450 CYP13A8
    EC=1.14.-.-

Gene names

Name:	cyp-13A8
Synonyms:	cyp13a8
ORF Names:	T10B9.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of locomotion Inferred from mutant phenotype. Source: WormBase
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Putative cytochrome P450 CYP13A8		PRO_0000052268
Sites
	Metal binding	455	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27516-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 718D86C86B7D8EEE	FASTA	509	58,565
	10 20 30 40 50 60 MIFELILISI VTYYFWHWTF WKRRGLPGPW GVPIFGKAGA MLEDSFPPGY TLQKWTKEYG 70 80 90 100 110 120 KIYGFTEGMQ KVMVISDPDL VQEILVKQYD NFYGRKHNPV QGDPDKDKDI HIVGAQGFRW 130 140 150 160 170 180 KRLRTITAPA FSNGSIKKVL TTMEDSTQEL MKKLREESEN GKAVNMHLFY QEYTFDVISR 190 200 210 220 230 240 VAMGQPDSQM FKNPLLKDVK GFFEHNRWQI WMFSGGFPFA VSFLKWLFIK VGKFGAGPFI 250 260 270 280 290 300 VVQKSVTDAV MSRIAQREAD KKHGVEPGEA ADYIDMFLNA RAEVEHFGES NDEFHKSSSY 310 320 330 340 350 360 NNRQLTTQEI ISQCFVFLVA GFDTTAISLS YVTYFLALNP KIQSKLQDEV DKECPNDEIT 370 380 390 400 410 420 FDQLSKLKYM DNVIKESLRL FPFASFANSR RCMRNTVIGE QIVEAGVDVM IDTWTLHHDK 430 440 450 460 470 480 NVWGNDVEEF KPERWDSPLT PQQAYLSFGA GPRVCLGMRF ALLEQKGLLS HILKKYTFET 490 500 NAKTQLPIKL VGRATARPEN LFLSLKPRV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z95623, Z48717 Genomic DNA. Translation: CAB09134.1. Z48717, Z95623 Genomic DNA. Translation: CAA88611.1.
PIR	T24785.
RefSeq	NP_496115.1.
UniGene	Cel.14404
3D structure databases
HSSP	HSSP built from PDB template 1JPZ based on UniProtKB P14779.
ModBase	Search...
Genome annotation databases
Ensembl	T10B9.4. Caenorhabditis elegans. [Contig view]
GeneID	188358.
KEGG	cel:T10B9.4.
NMPDR	fig|6239.3.peg.7043.
Organism-specific databases
WormBase	WBGene00011674. cyp-13A8.
WormPep	T10B9.4. CE13541. [WorfDB]
Phylogenomic databases
OMA	Q27516. NISLMEL.
Gene expression databases
ArrayExpress	Q27516.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	938506.

Entry information

Entry name

C13A8_CAEEL

Accession

Primary (citable) accession number: Q27516
Secondary accession number(s): O01997

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project