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Protein

Putative cytochrome P450 CYP13A8

Gene

cyp-13A8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi455Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211958 Miscellaneous substrates
R-CEL-211979 Eicosanoids
R-CEL-211981 Xenobiotics
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-CEL-5423646 Aflatoxin activation and detoxification
R-CEL-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome P450 CYP13A8 (EC:1.14.-.-)
Gene namesi
Name:cyp-13A8
Synonyms:cyp13a8
ORF Names:T10B9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT10B9.4 ; CE13541 ; WBGene00011674 ; cyp-13A8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522681 – 509Putative cytochrome P450 CYP13A8Add BLAST509

Proteomic databases

PaxDbiQ27516
PeptideAtlasiQ27516

Expressioni

Gene expression databases

BgeeiWBGene00011674

Interactioni

Protein-protein interaction databases

STRINGi6239.T10B9.4

Structurei

3D structure databases

ProteinModelPortaliQ27516
SMRiQ27516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000016177
InParanoidiQ27516
KOiK17861
OMAiCKGFFEN
OrthoDBiEOG091G0JNC
PhylomeDBiQ27516

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q27516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFELILISI VTYYFWHWTF WKRRGLPGPW GVPIFGKAGA MLEDSFPPGY
60 70 80 90 100
TLQKWTKEYG KIYGFTEGMQ KVMVISDPDL VQEILVKQYD NFYGRKHNPV
110 120 130 140 150
QGDPDKDKDI HIVGAQGFRW KRLRTITAPA FSNGSIKKVL TTMEDSTQEL
160 170 180 190 200
MKKLREESEN GKAVNMHLFY QEYTFDVISR VAMGQPDSQM FKNPLLKDVK
210 220 230 240 250
GFFEHNRWQI WMFSGGFPFA VSFLKWLFIK VGKFGAGPFI VVQKSVTDAV
260 270 280 290 300
MSRIAQREAD KKHGVEPGEA ADYIDMFLNA RAEVEHFGES NDEFHKSSSY
310 320 330 340 350
NNRQLTTQEI ISQCFVFLVA GFDTTAISLS YVTYFLALNP KIQSKLQDEV
360 370 380 390 400
DKECPNDEIT FDQLSKLKYM DNVIKESLRL FPFASFANSR RCMRNTVIGE
410 420 430 440 450
QIVEAGVDVM IDTWTLHHDK NVWGNDVEEF KPERWDSPLT PQQAYLSFGA
460 470 480 490 500
GPRVCLGMRF ALLEQKGLLS HILKKYTFET NAKTQLPIKL VGRATARPEN

LFLSLKPRV
Length:509
Mass (Da):58,565
Last modified:May 30, 2000 - v2
Checksum:i718D86C86B7D8EEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48717, Z95623 Genomic DNA Translation: CAA88611.1
PIRiT24785
RefSeqiNP_496115.1, NM_063714.1
UniGeneiCel.14404

Genome annotation databases

EnsemblMetazoaiT10B9.4; T10B9.4; WBGene00011674
GeneIDi188358
KEGGicel:CELE_T10B9.4
UCSCiT10B9.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiC13A8_CAEEL
AccessioniPrimary (citable) accession number: Q27516
Secondary accession number(s): O01997
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health