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Protein

Putative cytochrome P450 CYP13A8

Gene

cyp-13A8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi455 – 4551Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome P450 CYP13A8 (EC:1.14.-.-)
Gene namesi
Name:cyp-13A8
Synonyms:cyp13a8
ORF Names:T10B9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT10B9.4; CE13541; WBGene00011674; cyp-13A8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Putative cytochrome P450 CYP13A8PRO_0000052268Add
BLAST

Proteomic databases

PaxDbiQ27516.

Interactioni

Protein-protein interaction databases

STRINGi6239.T10B9.4.

Structurei

3D structure databases

ProteinModelPortaliQ27516.
SMRiQ27516. Positions 20-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiQ27516.
KOiK17861.
OMAiCPNDEIT.
OrthoDBiEOG744TBS.
PhylomeDBiQ27516.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFELILISI VTYYFWHWTF WKRRGLPGPW GVPIFGKAGA MLEDSFPPGY
60 70 80 90 100
TLQKWTKEYG KIYGFTEGMQ KVMVISDPDL VQEILVKQYD NFYGRKHNPV
110 120 130 140 150
QGDPDKDKDI HIVGAQGFRW KRLRTITAPA FSNGSIKKVL TTMEDSTQEL
160 170 180 190 200
MKKLREESEN GKAVNMHLFY QEYTFDVISR VAMGQPDSQM FKNPLLKDVK
210 220 230 240 250
GFFEHNRWQI WMFSGGFPFA VSFLKWLFIK VGKFGAGPFI VVQKSVTDAV
260 270 280 290 300
MSRIAQREAD KKHGVEPGEA ADYIDMFLNA RAEVEHFGES NDEFHKSSSY
310 320 330 340 350
NNRQLTTQEI ISQCFVFLVA GFDTTAISLS YVTYFLALNP KIQSKLQDEV
360 370 380 390 400
DKECPNDEIT FDQLSKLKYM DNVIKESLRL FPFASFANSR RCMRNTVIGE
410 420 430 440 450
QIVEAGVDVM IDTWTLHHDK NVWGNDVEEF KPERWDSPLT PQQAYLSFGA
460 470 480 490 500
GPRVCLGMRF ALLEQKGLLS HILKKYTFET NAKTQLPIKL VGRATARPEN

LFLSLKPRV
Length:509
Mass (Da):58,565
Last modified:May 30, 2000 - v2
Checksum:i718D86C86B7D8EEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48717, Z95623 Genomic DNA. Translation: CAA88611.1.
PIRiT24785.
RefSeqiNP_496115.1. NM_063714.1.
UniGeneiCel.14404.

Genome annotation databases

EnsemblMetazoaiT10B9.4; T10B9.4; WBGene00011674.
GeneIDi188358.
KEGGicel:CELE_T10B9.4.
UCSCiT10B9.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48717, Z95623 Genomic DNA. Translation: CAA88611.1.
PIRiT24785.
RefSeqiNP_496115.1. NM_063714.1.
UniGeneiCel.14404.

3D structure databases

ProteinModelPortaliQ27516.
SMRiQ27516. Positions 20-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T10B9.4.

Proteomic databases

PaxDbiQ27516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT10B9.4; T10B9.4; WBGene00011674.
GeneIDi188358.
KEGGicel:CELE_T10B9.4.
UCSCiT10B9.4. c. elegans.

Organism-specific databases

CTDi188358.
WormBaseiT10B9.4; CE13541; WBGene00011674; cyp-13A8.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiQ27516.
KOiK17861.
OMAiCPNDEIT.
OrthoDBiEOG744TBS.
PhylomeDBiQ27516.

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi938506.
PROiQ27516.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiC13A8_CAEEL
AccessioniPrimary (citable) accession number: Q27516
Secondary accession number(s): O01997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.