Q27515 (C13A6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome P450 CYP13A6
EC=1.14.-.-

Gene names

Name:	cyp-13A6
Synonyms:	cyp13a6
ORF Names:	T10B9.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Putative cytochrome P450 CYP13A6		PRO_0000052266
Sites
	Metal binding	463	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27515 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3B17B7A30E2792CA	FASTA	518	59,445
	10 20 30 40 50 60 MIFVLLSAVL LGVFTYSVWI WSYFIRKGIK GPRGFPGIGM LIQTIDHENP PFLKYRDWTK 70 80 90 100 110 120 QYGPVYGFTE GPQQTMIISE PEMVNEIFKK QFDNFYGRKL RPIIGDPEKD KRVNIFSTQG 130 140 150 160 170 180 KRWKRLRTLS SPSFSNNSLR KVRNSVQECG TEILWNIEQK VRKNEDIDML IVYQEYTLGV 190 200 210 220 230 240 ISRIALGQSE SNMFKNPLLP KVQAIFNGSW HVFLITGIFP PLAGVFRKMS KMLPASFIPA 250 260 270 280 290 300 FKIFDLIEVA VQARIDQRAK DEIKGVEPGE PQDFIDLFLD ARVPDVKILS GEANEDFAKS 310 320 330 340 350 360 SVVKINKELT FDEIIAQCFV FLAAGFDTTA LSLSYATYLL ATHPEIQTKL QEEVDRECPD 370 380 390 400 410 420 PEIFFDHLSK LKYLECVMKE TLRLYPLGTT ANTRKCMRET TINGVNFDEG MNIQVDTWTL 430 440 450 460 470 480 HHNPRIWGED VEDFKPERWE NGACEHLEHN GSYIPFGSGP RQCIGMRLAQ MEQKILLAQI 490 500 510 LKEYSFRTTK NTQIPVKLVG KLTLSPESVI VKLEPRDS

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48717 Genomic DNA. Translation: CAA88605.1.
PIR	T24779.
RefSeq	NP_496113.1. NM_063712.2.
UniGene	Cel.35645.
3D structure databases
ProteinModelPortal	Q27515.
SMR	Q27515. Positions 21-518.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27515.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T10B9.3; T10B9.3; T10B9.3.
GeneID	188357.
KEGG	cel:T10B9.3.
NMPDR	fig|6239.3.peg.7041.
UCSC	T10B9.3. c. elegans.
Organism-specific databases
CTD	188357.
WormBase	T10B9.3; CE01657; WBGene00011673; cyp-13A6.
Phylogenomic databases
eggNOG	meNOG09107.
GeneTree	EMGT00050000001178.
HOGENOM	HBG389200.
InParanoid	Q27515.
OMA	TIDHENP.
PhylomeDB	Q27515.
Gene expression databases
ArrayExpress	Q27515.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
KO	K00517.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	938502.

Entry information

Entry name

C13A6_CAEEL

Accession

Primary (citable) accession number: Q27515

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project