Reviewed, UniProtKB/Swiss-Prot Q27513 (C13A4_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative cytochrome P450 CYP13A4
    EC=1.14.-.-

Gene names

Name:	cyp-13A4
Synonyms:	cyp13a4
ORF Names:	T10B9.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	determination of adult life span Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Putative cytochrome P450 CYP13A4		PRO_0000052264
Sites
	Metal binding	464	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27513-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 996C1172B8D64E93	FASTA	520	59,371
	10 20 30 40 50 60 MSLSLLIAGA LFIGFLTYYI WIWSFWIRKG VKGPRGFPFF GVILKFHDYE NPGLLKLGEW 70 80 90 100 110 120 TKKYGSIYGI TEGVEKTLVV SNPEFVHEVF VKQFDNFYGR KTNPIQGDPN KNKRAHLVLA 130 140 150 160 170 180 QGHRWKRLRT LASPTFSNKS LRKIMSTVEE TVVELMRHLD EASAKGKAVD LLDYYQEFTL 190 200 210 220 230 240 DIIGRIAMGQ TESLMFRNPM LPKVKEIFKK GGKMPFLIAG VFPIAGTLMR QLFMKFPKFS 250 260 270 280 290 300 PAFGIMNTME KALNKRLEQR AADKKAGIEP SGEPQDFIDL FLDARANVDF IEEESTLGFA 310 320 330 340 350 360 KSEVLKVDKH LTFDEIIGQL FVFLLAGYDT TALSLSYSSY LLATHPEIQK KLQEEVDREC 370 380 390 400 410 420 PDPEVTFDQI SKLKYMECVV KEALRMYPLA SLVHNRKCMK KTNVLGVEID EGTNVQVDTW 430 440 450 460 470 480 TLHYDPKVWG DDASEFKPER WETGDELFYA KGGYLPFGMG PRICIGMRLA MMEEKLLLTH 490 500 510 520 ILKKYTFDTS TETEIPLKLV GSATIAPRNV MLKLTPRHSN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z48717 Genomic DNA. Translation: CAA88603.1.
PIR	T24777.
RefSeq	NP_496111.1.
UniGene	Cel.14407
3D structure databases
HSSP	HSSP built from PDB template 1JME based on UniProtKB P14779.
ModBase	Search...
Genome annotation databases
Ensembl	T10B9.1. Caenorhabditis elegans. [Contig view]
GeneID	188355.
KEGG	cel:T10B9.1.
NMPDR	fig|6239.3.peg.7039.
Organism-specific databases
WormBase	WBGene00011671. cyp-13A4.
WormPep	T10B9.1. CE01654. [WorfDB]
Phylogenomic databases
OMA	Q27513. RIDIVLE.
Gene expression databases
ArrayExpress	Q27513.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	938494.

Entry information

Entry name

C13A4_CAEEL

Accession

Primary (citable) accession number: Q27513

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project