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Protein

Annexin

Gene

nex-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: WormBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • heparan sulfate proteoglycan binding Source: WormBase
  • heparin binding Source: WormBase
  • phosphatidylethanolamine binding Source: WormBase
  • phosphatidylserine binding Source: WormBase

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:nex-2Imported
ORF Names:CELE_T07C4.9Imported, T07C4.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.9a; CE23956; WBGene00003589; nex-2.

PTM / Processingi

Proteomic databases

EPDiQ27512.
PaxDbiQ27512.
PeptideAtlasiQ27512.

Expressioni

Gene expression databases

BgeeiWBGene00003589.
ExpressionAtlasiQ27512. baseline and differential.

Interactioni

GO - Molecular functioni

  • heparan sulfate proteoglycan binding Source: WormBase

Protein-protein interaction databases

IntActiQ27512. 1 interactor.
STRINGi6239.T07C4.9a.

Structurei

3D structure databases

ProteinModelPortaliQ27512.
SMRiQ27512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
InParanoidiQ27512.
KOiK17095.
OMAiLENWIAG.
OrthoDBiEOG091G0H6H.
PhylomeDBiQ27512.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRKFVMSG IQDVLDNKLG GLGGNNKQQQ PSSQQSSQEP SNMNSGGGYP
60 70 80 90 100
NQQPSYGGYG QPPQQPGYGN GSYDPYGQPQ QQPYPGGGGQ PPYPGSNSNQ
110 120 130 140 150
GGGGYPGQGG APYPGGSGGY PQAPQYGFSG GQGSAPQPNQ GGYPPQQQQY
160 170 180 190 200
PPQQGYQQGG QQQGGGGFFP NQGYGQPVMI GTPSVFPVQG FNSNADAEVL
210 220 230 240 250
RKAMKGLGCN NSKVISILCQ RTNWQRQEIS KAFKVMYGKD LIKELKGELH
260 270 280 290 300
GDFEDLILAL MDAPAIYDAK QLHRAMEGLG TKESVLIEIM TSRTNAQIQQ
310 320 330 340 350
VRDAYKMLFK KDLERDLIGE TSGHFKRLLV SLCAGGRDES SQTDGLRANQ
360 370 380 390 400
DARRLLQAGE KRLGTDESTF NAILASQNFS QLRLVFEEYQ KASNHSIEKA
410 420 430 440 450
IEFEFSGDIR DGLLAVIAVI RNRPAYFAKL LHDSMKGLGT RDNDLIRLCV
460 470 480 490
TRAEYDMGDI RNMFQSLYRT SLENMIKGDC SGAYKEGLIA LVNGNRG
Length:497
Mass (Da):53,961
Last modified:May 1, 2000 - v2
Checksum:i114354686D78764F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA82571.2.
PIRiS41022.
RefSeqiNP_001022755.1. NM_001027584.3.
UniGeneiCel.32947.

Genome annotation databases

EnsemblMetazoaiT07C4.9a; T07C4.9a; WBGene00003589.
GeneIDi176446.
KEGGicel:CELE_T07C4.9.

Similar proteinsi

Entry informationi

Entry nameiQ27512_CAEEL
AccessioniPrimary (citable) accession number: Q27512
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported