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Protein

Annexin

Gene

nex-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: WormBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • heparan sulfate proteoglycan binding Source: WormBase
  • heparin binding Source: WormBase
  • phosphatidylethanolamine binding Source: WormBase
  • phosphatidylserine binding Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:nex-2Imported
ORF Names:CELE_T07C4.9Imported, T07C4.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.9a; CE23956; WBGene00003589; nex-2.

PTM / Processingi

Proteomic databases

EPDiQ27512.
PaxDbiQ27512.
PeptideAtlasiQ27512.

Expressioni

Gene expression databases

BgeeiWBGene00003589.
ExpressionAtlasiQ27512. differential.

Interactioni

Protein-protein interaction databases

IntActiQ27512. 1 interactor.
STRINGi6239.T07C4.9a.

Structurei

3D structure databases

ProteinModelPortaliQ27512.
SMRiQ27512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 4 annexin repeats.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
InParanoidiQ27512.
KOiK17095.
OMAiESCFNAI.
OrthoDBiEOG091G0H6H.
PhylomeDBiQ27512.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRKFVMSG IQDVLDNKLG GLGGNNKQQQ PSSQQSSQEP SNMNSGGGYP
60 70 80 90 100
NQQPSYGGYG QPPQQPGYGN GSYDPYGQPQ QQPYPGGGGQ PPYPGSNSNQ
110 120 130 140 150
GGGGYPGQGG APYPGGSGGY PQAPQYGFSG GQGSAPQPNQ GGYPPQQQQY
160 170 180 190 200
PPQQGYQQGG QQQGGGGFFP NQGYGQPVMI GTPSVFPVQG FNSNADAEVL
210 220 230 240 250
RKAMKGLGCN NSKVISILCQ RTNWQRQEIS KAFKVMYGKD LIKELKGELH
260 270 280 290 300
GDFEDLILAL MDAPAIYDAK QLHRAMEGLG TKESVLIEIM TSRTNAQIQQ
310 320 330 340 350
VRDAYKMLFK KDLERDLIGE TSGHFKRLLV SLCAGGRDES SQTDGLRANQ
360 370 380 390 400
DARRLLQAGE KRLGTDESTF NAILASQNFS QLRLVFEEYQ KASNHSIEKA
410 420 430 440 450
IEFEFSGDIR DGLLAVIAVI RNRPAYFAKL LHDSMKGLGT RDNDLIRLCV
460 470 480 490
TRAEYDMGDI RNMFQSLYRT SLENMIKGDC SGAYKEGLIA LVNGNRG
Length:497
Mass (Da):53,961
Last modified:May 1, 2000 - v2
Checksum:i114354686D78764F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA82571.2.
PIRiS41022.
RefSeqiNP_001022755.1. NM_001027584.3.
UniGeneiCel.32947.

Genome annotation databases

EnsemblMetazoaiT07C4.9a; T07C4.9a; WBGene00003589.
GeneIDi176446.
KEGGicel:CELE_T07C4.9.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA82571.2.
PIRiS41022.
RefSeqiNP_001022755.1. NM_001027584.3.
UniGeneiCel.32947.

3D structure databases

ProteinModelPortaliQ27512.
SMRiQ27512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ27512. 1 interactor.
STRINGi6239.T07C4.9a.

Proteomic databases

EPDiQ27512.
PaxDbiQ27512.
PeptideAtlasiQ27512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT07C4.9a; T07C4.9a; WBGene00003589.
GeneIDi176446.
KEGGicel:CELE_T07C4.9.

Organism-specific databases

CTDi176446.
WormBaseiT07C4.9a; CE23956; WBGene00003589; nex-2.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
InParanoidiQ27512.
KOiK17095.
OMAiESCFNAI.
OrthoDBiEOG091G0H6H.
PhylomeDBiQ27512.

Gene expression databases

BgeeiWBGene00003589.
ExpressionAtlasiQ27512. differential.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27512_CAEEL
AccessioniPrimary (citable) accession number: Q27512
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.