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Protein

Histone H2A.V

Gene

htz-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.V
Alternative name(s):
H2A.F/Z
Gene namesi
Name:htz-1
ORF Names:R08C7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR08C7.3; CE07426; WBGene00019947; htz-1.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome By similarity

  • Note: Localizes in punctate structures in the nucleus.1 Publication

GO - Cellular componenti

  • condensed chromosome Source: WormBase
  • nucleosome Source: UniProtKB-KW
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 140139Histone H2A.VPRO_0000239071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki124 – 124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-124 gives a specific tag for epigenetic transcriptional repression.By similarity
May be acetylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ27511.
PaxDbiQ27511.
PRIDEiQ27511.

Expressioni

Tissue specificityi

Expressed in somatic gonadal cells.1 Publication

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AV forms a heterodimer with H2B (By similarity).By similarity

Protein-protein interaction databases

BioGridi42342. 3 interactions.
STRINGi6239.R08C7.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ27511.
SMRiQ27511. Positions 20-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
InParanoidiQ27511.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG7M0NTR.
PhylomeDBiQ27511.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGKGKAGK DSGKSKSKVV SRSARAGLQF PVGRIHRFLK QRTTSSGRVG
60 70 80 90 100
ATAAVYSAAI LEYLTAEVLE LAGNASKDLK VKRITPRHLH LAIRGDEELD
110 120 130 140
TLIKATIAGG GVIPHIHRYL MNKKGAPVPG KPGAPGQGPQ
Length:140
Mass (Da):14,669
Last modified:January 23, 2007 - v3
Checksum:i3E3435A8FAE6D821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081646 Genomic DNA. Translation: CCD73086.1.
PIRiT29662.
RefSeqiNP_500569.1. NM_068168.6.
UniGeneiCel.17489.

Genome annotation databases

EnsemblMetazoaiR08C7.3.1; R08C7.3.1; WBGene00019947.
R08C7.3.2; R08C7.3.2; WBGene00019947.
R08C7.3.3; R08C7.3.3; WBGene00019947.
GeneIDi177212.
KEGGicel:CELE_R08C7.3.
UCSCiR08C7.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081646 Genomic DNA. Translation: CCD73086.1.
PIRiT29662.
RefSeqiNP_500569.1. NM_068168.6.
UniGeneiCel.17489.

3D structure databases

ProteinModelPortaliQ27511.
SMRiQ27511. Positions 20-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42342. 3 interactions.
STRINGi6239.R08C7.3.1.

Proteomic databases

EPDiQ27511.
PaxDbiQ27511.
PRIDEiQ27511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR08C7.3.1; R08C7.3.1; WBGene00019947.
R08C7.3.2; R08C7.3.2; WBGene00019947.
R08C7.3.3; R08C7.3.3; WBGene00019947.
GeneIDi177212.
KEGGicel:CELE_R08C7.3.
UCSCiR08C7.3.1. c. elegans.

Organism-specific databases

CTDi177212.
WormBaseiR08C7.3; CE07426; WBGene00019947; htz-1.

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
InParanoidiQ27511.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG7M0NTR.
PhylomeDBiQ27511.

Miscellaneous databases

NextBioi895806.
PROiQ27511.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans."
    Shibata Y., Sawa H., Nishiwaki K.
    Development 141:209-218(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiH2AV_CAEEL
AccessioniPrimary (citable) accession number: Q27511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.