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Protein

Histone H2A.V

Gene

htz-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.V
Alternative name(s):
H2A.F/Z
Gene namesi
Name:htz-1
ORF Names:R08C7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR08C7.3; CE07426; WBGene00019947; htz-1.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome By similarity

  • Note: Localizes in punctate structures in the nucleus.1 Publication

GO - Cellular componenti

  • condensed chromosome Source: WormBase
  • nuclear chromatin Source: GO_Central
  • nucleosome Source: UniProtKB-KW
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002390712 – 140Histone H2A.VAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-124 gives a specific tag for epigenetic transcriptional repression.By similarity
May be acetylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ27511.
PaxDbiQ27511.
PeptideAtlasiQ27511.
PRIDEiQ27511.

Expressioni

Tissue specificityi

Expressed in somatic gonadal cells.1 Publication

Gene expression databases

BgeeiWBGene00019947.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AV forms a heterodimer with H2B (By similarity).By similarity

Protein-protein interaction databases

BioGridi42342. 3 interactors.
STRINGi6239.R08C7.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ27511.
SMRiQ27511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
InParanoidiQ27511.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27511.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGKGKAGK DSGKSKSKVV SRSARAGLQF PVGRIHRFLK QRTTSSGRVG
60 70 80 90 100
ATAAVYSAAI LEYLTAEVLE LAGNASKDLK VKRITPRHLH LAIRGDEELD
110 120 130 140
TLIKATIAGG GVIPHIHRYL MNKKGAPVPG KPGAPGQGPQ
Length:140
Mass (Da):14,669
Last modified:January 23, 2007 - v3
Checksum:i3E3435A8FAE6D821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081646 Genomic DNA. Translation: CCD73086.1.
PIRiT29662.
RefSeqiNP_500569.1. NM_068168.6.
UniGeneiCel.17489.

Genome annotation databases

EnsemblMetazoaiR08C7.3.1; R08C7.3.1; WBGene00019947.
R08C7.3.2; R08C7.3.2; WBGene00019947.
R08C7.3.3; R08C7.3.3; WBGene00019947.
GeneIDi177212.
KEGGicel:CELE_R08C7.3.
UCSCiR08C7.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081646 Genomic DNA. Translation: CCD73086.1.
PIRiT29662.
RefSeqiNP_500569.1. NM_068168.6.
UniGeneiCel.17489.

3D structure databases

ProteinModelPortaliQ27511.
SMRiQ27511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42342. 3 interactors.
STRINGi6239.R08C7.3.1.

Proteomic databases

EPDiQ27511.
PaxDbiQ27511.
PeptideAtlasiQ27511.
PRIDEiQ27511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR08C7.3.1; R08C7.3.1; WBGene00019947.
R08C7.3.2; R08C7.3.2; WBGene00019947.
R08C7.3.3; R08C7.3.3; WBGene00019947.
GeneIDi177212.
KEGGicel:CELE_R08C7.3.
UCSCiR08C7.3.1. c. elegans.

Organism-specific databases

CTDi177212.
WormBaseiR08C7.3; CE07426; WBGene00019947; htz-1.

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
InParanoidiQ27511.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27511.

Miscellaneous databases

PROiQ27511.

Gene expression databases

BgeeiWBGene00019947.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2AV_CAEEL
AccessioniPrimary (citable) accession number: Q27511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.