Reviewed, UniProtKB/Swiss-Prot Q27504 (CAH3_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative carbonic anhydrase 3
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase 3

Gene names

Name:	cah-3
ORF Names:	K05G3.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Putative carbonic anhydrase 3		PRO_0000077444
Sites
	Metal binding	91	1	Zinc; catalytic
	Metal binding	93	1	Zinc; catalytic
	Metal binding	116	1	Zinc; catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q27504-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E5A405E23A17719C	FASTA	246	28,121
	10 20 30 40 50 60 MTGHWSYCDD DECGPNRWPT GQHQSPINID LGEVERKDTH DGIKFVNYDH PIQGDIVNNG 70 80 90 100 110 120 HSVQMTPELR SEHPEIYGGG LDQVYRLVQY HFHWGENDNE GSEHTLGGLR YPAELHLVHQ 130 140 150 160 170 180 GVEDPGKLAV VGVFLQLGKE GKALSNEERV LGKLCNPETV TRVENVRLSE KLPANKRSFW 190 200 210 220 230 240 RYEGSLTTPP CSEIVTWTIF TEPVTVTHDQ LELFRQVQDI EKRPIKKNYR PTQNLNDRKI VHIVAN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U41539 Genomic DNA. Translation: AAB52498.1.
PIR	T16575.
RefSeq	NP_510674.1.
UniGene	Cel.22984
3D structure databases
HSSP	HSSP built from PDB template 1URT based on UniProtKB P23589.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q27504. 2 interactions.
STRING	Q27504.
Genome annotation databases
Ensembl	K05G3.3; K05G3.3; K05G3.3; Caenorhabditis elegans. [Genome view]
GeneID	181713.
KEGG	cel:K05G3.3.
NMPDR	fig|6239.3.peg.25590.
UCSC	K05G3.3. c. elegans.
Organism-specific databases
CTD	181713.
WormBase	WBGene00000281. cah-3.
WormPep	K05G3.3. CE04755. [WorfDB]
Phylogenomic databases
OMA	IVHIVAN.
Enzyme and pathway databases
BRENDA	4.2.1.1. 672.
Gene expression databases
ArrayExpress	Q27504.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	915050.

Entry information

Entry name

CAH3_CAEEL

Accession

Primary (citable) accession number: Q27504

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project