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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-33e2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • long-chain fatty acid metabolic process Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-33e2Imported
Synonyms:cyp-33E2Imported
ORF Names:CELE_F42A9.5Imported, F42A9.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF42A9.5; CE41900; WBGene00018334; cyp-33E2.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ27499.
PaxDbiQ27499.
PRIDEiQ27499.

Interactioni

Protein-protein interaction databases

STRINGi6239.F42A9.5.

Structurei

3D structure databases

ProteinModelPortaliQ27499.
SMRiQ27499. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27499.
KOiK17955.
OrthoDBiEOG77M8NM.
PhylomeDBiQ27499.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILFIVLSIV SIYLFDLFYW KRRNLPPGPL PLPLVGNLHM MSDDVKPGYS
60 70 80 90 100
LFSNLKEQYG HVYTFWMASL PIVHVTDWNL IKQHFIKDGG NFVGRPEFPM
110 120 130 140 150
SIELRQGPYG IIESHGDRWV QQRRFALHVL RDFGLGKNLM EEKVLGEVTA
160 170 180 190 200
MLDRLRKTMD EVDMQSVFDA SVGSVINNLL FGYRYDETNI AEFLDLKEKL
210 220 230 240 250
NNHFQLAAKP IGGLIGMNPW LGYFPYFSGY KNVMIQNWMG LVEMFRKQAN
260 270 280 290 300
EKLATIDYES DDYSDYVEAF LKERKKHENE KDFGGFEMEQ LDSVCFDLWV
310 320 330 340 350
AGMETTSNTL NWALLYVLRN PEVRQKVYEE LDREIGSDRI ITTSDKPKLN
360 370 380 390 400
YINATINESQ RLANLLPMNL ARSTTKDVEI AGYHIKKNTV IIPQISLVLY
410 420 430 440 450
NPEIFPEPYE FKPERFLESD GSLKKVEELV PFSIGKRQCP GEGLAKMELL
460 470 480 490
LFFANLFNRF DIQLHQSNPN PSVEKEFGVT MKAKSYRLKL KDRH
Length:494
Mass (Da):57,340
Last modified:February 5, 2008 - v2
Checksum:iFD9D098DFB34F508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67662.1.
RefSeqiNP_501470.2. NM_069069.4.
UniGeneiCel.12951.

Genome annotation databases

EnsemblMetazoaiF42A9.5; F42A9.5; WBGene00018334.
GeneIDi185653.
KEGGicel:CELE_F42A9.5.
UCSCiF42A9.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD67662.1.
RefSeqiNP_501470.2. NM_069069.4.
UniGeneiCel.12951.

3D structure databases

ProteinModelPortaliQ27499.
SMRiQ27499. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F42A9.5.

Proteomic databases

EPDiQ27499.
PaxDbiQ27499.
PRIDEiQ27499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42A9.5; F42A9.5; WBGene00018334.
GeneIDi185653.
KEGGicel:CELE_F42A9.5.
UCSCiF42A9.5. c. elegans.

Organism-specific databases

CTDi185653.
WormBaseiF42A9.5; CE41900; WBGene00018334; cyp-33E2.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27499.
KOiK17955.
OrthoDBiEOG77M8NM.
PhylomeDBiQ27499.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi929026.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27499_CAEEL
AccessioniPrimary (citable) accession number: Q27499
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: February 5, 2008
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.