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Protein

Serine/threonine-protein phosphatase PP1-alpha

Gene

gsp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion (PubMed:11940606, PubMed:14622138). Dephosphorylates histone H3 at 'Ser-10' (PubMed:10975519). Dephosphorylates translation initiation factor eIF2alpha (PubMed:22719267). Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation (PubMed:12163466).5 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese 2By similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi173Manganese 2By similarity1
Metal bindingi248Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • covalent chromatin modification Source: UniProtKB-KW
  • meiotic cell cycle Source: UniProtKB-KW
  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-CEL-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha (EC:3.1.3.16)
Alternative name(s):
CeGLC-7-alpha
Glc seven-like phosphatase 1
Gene namesi
Name:gsp-1
ORF Names:F29F11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF29F11.6a; CE20735; WBGene00001747; gsp-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686371 – 329Serine/threonine-protein phosphatase PP1-alphaAdd BLAST329

Proteomic databases

EPDiQ27497.
PaxDbiQ27497.

PTM databases

iPTMnetiQ27497.

Expressioni

Gene expression databases

BgeeiWBGene00001747.
ExpressionAtlasiQ27497. baseline.

Interactioni

Protein-protein interaction databases

BioGridi44515. 2 interactors.
DIPiDIP-55373N.
IntActiQ27497. 3 interactors.
STRINGi6239.F29F11.6b.

Structurei

3D structure databases

ProteinModelPortaliQ27497.
SMRiQ27497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN85. Eukaryota.
ENOG410XPVF. LUCA.
GeneTreeiENSGT00530000062911.
HOGENOMiHOG000172697.
InParanoidiQ27497.
KOiK06269.
OMAiIFIQQPI.
OrthoDBiEOG091G0EKF.
PhylomeDBiQ27497.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KVKYPENFFL LRGNHECASI NRIYGFYDEC KRRFSIKLWK
160 170 180 190 200
TFTDCFNCLP IAALIDEKIF CCHGGLSPDL QNMEQIRRVM RPTDVPDTGL
210 220 230 240 250
LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE
310 320
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK
Length:329
Mass (Da):37,205
Last modified:January 1, 1999 - v2
Checksum:i500145324CA16D1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73974 Genomic DNA. Translation: CAA98273.1.
PIRiT21553.
RefSeqiNP_001256249.1. NM_001269320.1.
NP_001256250.1. NM_001269321.1.
UniGeneiCel.17676.

Genome annotation databases

EnsemblMetazoaiF29F11.6a; F29F11.6a; WBGene00001747.
F29F11.6b; F29F11.6b; WBGene00001747.
GeneIDi179486.
KEGGicel:CELE_F29F11.6.
UCSCiF29F11.6. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiGLC7A_CAEEL
AccessioniPrimary (citable) accession number: Q27497
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1999
Last modified: September 27, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families