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Q27497 (GLC7A_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1-alpha

EC=3.1.3.16
Alternative name(s):
CeGLC-7-alpha
Glc seven-like phosphatase 1
Gene names
Name:gsp-1
ORF Names:F29F11.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Ref.2 Ref.3 Ref.4 Ref.5

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Serine/threonine-protein phosphatase PP1-alpha
PRO_0000268637

Sites

Active site1251Proton donor By similarity
Metal binding641Iron By similarity
Metal binding661Iron By similarity
Metal binding921Iron By similarity
Metal binding921Manganese By similarity
Metal binding1241Manganese By similarity
Metal binding1731Manganese By similarity
Metal binding2481Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27497 [UniParc].

Last modified January 1, 1999. Version 2.
Checksum: 500145324CA16D1B

FASTA32937,205
        10         20         30         40         50         60 
MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP ILLELEAPLK 

        70         80         90        100        110        120 
ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS LETICLLLAY KVKYPENFFL 

       130        140        150        160        170        180 
LRGNHECASI NRIYGFYDEC KRRFSIKLWK TFTDCFNCLP IAALIDEKIF CCHGGLSPDL 

       190        200        210        220        230        240 
QNMEQIRRVM RPTDVPDTGL LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD 

       250        260        270        280        290        300 
LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE 

       310        320 
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes."
Hsu J.-Y., Sun Z.-W., Li X., Reuben M., Tatchell K., Bishop D.K., Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., Lin R., Smith M.M., Allis C.D.
Cell 102:279-291(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis."
Rogers E., Bishop J.D., Waddle J.A., Schumacher J.M., Lin R.
J. Cell Biol. 157:219-229(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases."
Rutledge E., Denton J., Strange K.
J. Cell Biol. 158:435-444(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis."
Sasagawa Y., Urano T., Kohara Y., Takahashi H., Higashitani A.
Genes Cells 8:857-872(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73974 Genomic DNA. Translation: CAA98273.1.
PIRT21553.
RefSeqNP_001256249.1. NM_001269320.1.
NP_001256250.1. NM_001269321.1.
UniGeneCel.17676.

3D structure databases

ProteinModelPortalQ27497.
SMRQ27497. Positions 4-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44515. 2 interactions.
DIPDIP-55373N.
IntActQ27497. 3 interactions.
STRING6239.F29F11.6.

Proteomic databases

PaxDbQ27497.
PRIDEQ27497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF29F11.6a; F29F11.6a; F29F11.6.
F29F11.6b; F29F11.6b; F29F11.6.
GeneID179486.
KEGGcel:CELE_F29F11.6.
UCSCF29F11.6. c. elegans.

Organism-specific databases

CTD179486.
WormBaseF29F11.6a; CE20735; WBGene00001747; gsp-1.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
InParanoidQ27497.
KOK06269.
OMAPDLQGME.
PhylomeDBQ27497.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio905606.
PROQ27497.

Entry information

Entry nameGLC7A_CAEEL
AccessionPrimary (citable) accession number: Q27497
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1999
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase