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Q27497

- GLC7A_CAEEL

UniProt

Q27497 - GLC7A_CAEEL

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Protein

Serine/threonine-protein phosphatase PP1-alpha

Gene
gsp-1, F29F11.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation.4 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1 By similarity
Metal bindingi66 – 661Manganese 1 By similarity
Metal bindingi92 – 921Manganese 1 By similarity
Metal bindingi92 – 921Manganese 2 By similarity
Metal bindingi124 – 1241Manganese 2 By similarity
Active sitei125 – 1251Proton donor By similarity
Metal bindingi173 – 1731Manganese 2 By similarity
Metal bindingi248 – 2481Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
  3. protein binding Source: WormBase

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. meiotic nuclear division Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_227023. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-alpha (EC:3.1.3.16)
Alternative name(s):
CeGLC-7-alpha
Glc seven-like phosphatase 1
Gene namesi
Name:gsp-1
ORF Names:F29F11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF29F11.6a; CE20735; WBGene00001747; gsp-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine/threonine-protein phosphatase PP1-alphaPRO_0000268637Add
BLAST

Proteomic databases

PaxDbiQ27497.
PRIDEiQ27497.

Interactioni

Protein-protein interaction databases

BioGridi44515. 2 interactions.
DIPiDIP-55373N.
IntActiQ27497. 3 interactions.
STRINGi6239.F29F11.6.

Structurei

3D structure databases

ProteinModelPortaliQ27497.
SMRiQ27497. Positions 4-309.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00530000062911.
HOGENOMiHOG000172697.
InParanoidiQ27497.
KOiK06269.
OMAiPDLQGME.
PhylomeDBiQ27497.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27497-1 [UniParc]FASTAAdd to Basket

« Hide

MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP    50
ILLELEAPLK ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS 100
LETICLLLAY KVKYPENFFL LRGNHECASI NRIYGFYDEC KRRFSIKLWK 150
TFTDCFNCLP IAALIDEKIF CCHGGLSPDL QNMEQIRRVM RPTDVPDTGL 200
LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD LDLICRAHQV 250
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE 300
KKAKYQYQGM NSGRPAVGGG RPGTTAGKK 329
Length:329
Mass (Da):37,205
Last modified:January 1, 1999 - v2
Checksum:i500145324CA16D1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73974 Genomic DNA. Translation: CAA98273.1.
PIRiT21553.
RefSeqiNP_001256249.1. NM_001269320.1.
NP_001256250.1. NM_001269321.1.
UniGeneiCel.17676.

Genome annotation databases

EnsemblMetazoaiF29F11.6a; F29F11.6a; WBGene00001747.
F29F11.6b; F29F11.6b; WBGene00001747.
GeneIDi179486.
KEGGicel:CELE_F29F11.6.
UCSCiF29F11.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73974 Genomic DNA. Translation: CAA98273.1 .
PIRi T21553.
RefSeqi NP_001256249.1. NM_001269320.1.
NP_001256250.1. NM_001269321.1.
UniGenei Cel.17676.

3D structure databases

ProteinModelPortali Q27497.
SMRi Q27497. Positions 4-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44515. 2 interactions.
DIPi DIP-55373N.
IntActi Q27497. 3 interactions.
STRINGi 6239.F29F11.6.

Proteomic databases

PaxDbi Q27497.
PRIDEi Q27497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F29F11.6a ; F29F11.6a ; WBGene00001747 .
F29F11.6b ; F29F11.6b ; WBGene00001747 .
GeneIDi 179486.
KEGGi cel:CELE_F29F11.6.
UCSCi F29F11.6. c. elegans.

Organism-specific databases

CTDi 179486.
WormBasei F29F11.6a ; CE20735 ; WBGene00001747 ; gsp-1.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00530000062911.
HOGENOMi HOG000172697.
InParanoidi Q27497.
KOi K06269.
OMAi PDLQGME.
PhylomeDBi Q27497.

Enzyme and pathway databases

Reactomei REACT_227023. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 905606.
PROi Q27497.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes."
    Hsu J.-Y., Sun Z.-W., Li X., Reuben M., Tatchell K., Bishop D.K., Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., Lin R., Smith M.M., Allis C.D.
    Cell 102:279-291(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis."
    Rogers E., Bishop J.D., Waddle J.A., Schumacher J.M., Lin R.
    J. Cell Biol. 157:219-229(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases."
    Rutledge E., Denton J., Strange K.
    J. Cell Biol. 158:435-444(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis."
    Sasagawa Y., Urano T., Kohara Y., Takahashi H., Higashitani A.
    Genes Cells 8:857-872(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGLC7A_CAEEL
AccessioniPrimary (citable) accession number: Q27497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1999
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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