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Protein

Histone H3.3-like type 1

Gene

his-70

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3.3-like type 1
Gene namesi
Name:his-70
ORF Names:E03A3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.4; CE44880; WBGene00001944; his-70.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002686332 – 134Histone H3.3-like type 1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysine; alternateBy similarity1
Modified residuei5N6-methylated lysine; alternateBy similarity1
Modified residuei10N6-acetyllysine; alternateBy similarity1
Modified residuei10N6-methylated lysine; alternateBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei37N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity
Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ27490.
PaxDbiQ27490.
PeptideAtlasiQ27490.

Expressioni

Gene expression databases

BgeeiWBGene00001944.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.E03A3.4.

Structurei

3D structure databases

ProteinModelPortaliQ27490.
SMRiQ27490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00840000129844.
HOGENOMiHOG000155290.
InParanoidiQ27490.
KOiK11253.
OMAiDSNICAI.
OrthoDBiEOG091G0XGD.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00622. HISTONEH3.
SMARTiView protein in SMART
SM00428. H3. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00959. HISTONE_H3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKHTARK SFGGKAPRKS LATKAARKVF PVDGQVKKRY RPSSNALKEI
60 70 80 90 100
RKYQKSTELL VRKLPFQRLV REVAQEIMPN VRFQSAAIQA LHEAAEAYLI
110 120 130
GLFEDTNLCA IHAKRVTIMP KDMQLARRIR GERG
Length:134
Mass (Da):15,286
Last modified:July 27, 2011 - v4
Checksum:i28819741B20BF017
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86229.2.
PIRiT20427.
RefSeqiNP_497812.2. NM_065411.2.
UniGeneiCel.10648.

Genome annotation databases

EnsemblMetazoaiE03A3.4; E03A3.4; WBGene00001944.
GeneIDi184006.
KEGGicel:CELE_E03A3.4.
UCSCiE03A3.4. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiH33L1_CAEEL
AccessioniPrimary (citable) accession number: Q27490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: July 5, 2017
This is version 112 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families