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Protein

Histone H3.3-like type 1

Gene

his-70

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3.3-like type 1
Gene namesi
Name:his-70
ORF Names:E03A3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.4 ; CE44880 ; WBGene00001944 ; his-70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002686332 – 134Histone H3.3-like type 1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysine; alternateBy similarity1
Modified residuei5N6-methylated lysine; alternateBy similarity1
Modified residuei10N6-acetyllysine; alternateBy similarity1
Modified residuei10N6-methylated lysine; alternateBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei37N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity
Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ27490
PaxDbiQ27490
PeptideAtlasiQ27490

Expressioni

Gene expression databases

BgeeiWBGene00001944

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.E03A3.4

Structurei

3D structure databases

ProteinModelPortaliQ27490
SMRiQ27490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000118967
HOGENOMiHOG000155290
InParanoidiQ27490
KOiK11253
OMAiDSNICAI
OrthoDBiEOG091G0XGD

Family and domain databases

Gene3Di1.10.20.101 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000164 Histone_H3/CENP-A
PANTHERiPTHR11426 PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00622 HISTONEH3
SMARTiView protein in SMART
SM00428 H3, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00959 HISTONE_H3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKHTARK SFGGKAPRKS LATKAARKVF PVDGQVKKRY RPSSNALKEI
60 70 80 90 100
RKYQKSTELL VRKLPFQRLV REVAQEIMPN VRFQSAAIQA LHEAAEAYLI
110 120 130
GLFEDTNLCA IHAKRVTIMP KDMQLARRIR GERG
Length:134
Mass (Da):15,286
Last modified:July 27, 2011 - v4
Checksum:i28819741B20BF017
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA Translation: CAA86229.2
PIRiT20427
RefSeqiNP_497812.2, NM_065411.2
UniGeneiCel.10648

Genome annotation databases

EnsemblMetazoaiE03A3.4; E03A3.4; WBGene00001944
GeneIDi184006
KEGGicel:CELE_E03A3.4
UCSCiE03A3.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiH33L1_CAEEL
AccessioniPrimary (citable) accession number: Q27490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome