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Protein

Histone H3.3-like type 1

Gene

his-70

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3.3-like type 1
Gene namesi
Name:his-70
ORF Names:E03A3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.4; CE44880; WBGene00001944; his-70.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002686332 – 134Histone H3.3-like type 1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysine; alternateBy similarity1
Modified residuei5N6-methylated lysine; alternateBy similarity1
Modified residuei10N6-acetyllysine; alternateBy similarity1
Modified residuei10N6-methylated lysine; alternateBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei37N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity
Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ27490.
PaxDbiQ27490.
PeptideAtlasiQ27490.

Expressioni

Gene expression databases

BgeeiWBGene00001944.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.E03A3.4.

Structurei

3D structure databases

ProteinModelPortaliQ27490.
SMRiQ27490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27490.
OMAiDSNICAI.
OrthoDBiEOG091G0XGD.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00959. HISTONE_H3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKHTARK SFGGKAPRKS LATKAARKVF PVDGQVKKRY RPSSNALKEI
60 70 80 90 100
RKYQKSTELL VRKLPFQRLV REVAQEIMPN VRFQSAAIQA LHEAAEAYLI
110 120 130
GLFEDTNLCA IHAKRVTIMP KDMQLARRIR GERG
Length:134
Mass (Da):15,286
Last modified:July 27, 2011 - v4
Checksum:i28819741B20BF017
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86229.2.
PIRiT20427.
RefSeqiNP_497812.2. NM_065411.2.
UniGeneiCel.10648.

Genome annotation databases

EnsemblMetazoaiE03A3.4; E03A3.4; WBGene00001944.
GeneIDi184006.
KEGGicel:CELE_E03A3.4.
UCSCiE03A3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86229.2.
PIRiT20427.
RefSeqiNP_497812.2. NM_065411.2.
UniGeneiCel.10648.

3D structure databases

ProteinModelPortaliQ27490.
SMRiQ27490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.E03A3.4.

Proteomic databases

EPDiQ27490.
PaxDbiQ27490.
PeptideAtlasiQ27490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE03A3.4; E03A3.4; WBGene00001944.
GeneIDi184006.
KEGGicel:CELE_E03A3.4.
UCSCiE03A3.4. c. elegans.

Organism-specific databases

CTDi184006.
WormBaseiE03A3.4; CE44880; WBGene00001944; his-70.

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27490.
OMAiDSNICAI.
OrthoDBiEOG091G0XGD.

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ27490.

Gene expression databases

BgeeiWBGene00001944.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00959. HISTONE_H3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH33L1_CAEEL
AccessioniPrimary (citable) accession number: Q27490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.