Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative histone H3.3-like type 3

Gene

his-69

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone H3.3-like type 3
Gene namesi
Name:his-69
ORF Names:E03A3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.3; CE00942; WBGene00001943; his-69.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit slow postembryonic growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Putative histone H3.3-like type 3PRO_0000268635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61N6-acetyllysineBy similarity
Modified residuei15 – 151N6-acetyllysineBy similarity
Modified residuei19 – 191N6-methylated lysineBy similarity
Modified residuei28 – 281N6-methylated lysineBy similarity
Modified residuei71 – 711N6-methylated lysineBy similarity

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ27489.
PRIDEiQ27489.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi48808. 2 interactions.
STRINGi6239.E03A3.3.

Structurei

3D structure databases

ProteinModelPortaliQ27489.
SMRiQ27489. Positions 4-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27489.
KOiK11253.
OMAiPRMGERN.
PhylomeDBiQ27489.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPGGKAPRK QLATKAARKN AIVVGAVKKP HRFRPGTVAL REIRRYQKST
60 70 80 90 100
DLLLRKLPFQ RLVREIAQDV KQDLRFQSAA IQALQEASEY FLVGLFEDTN
110 120
LCAIHAKRVT IMPKDMQLAR RIRGERN
Length:127
Mass (Da):14,523
Last modified:November 1, 1996 - v1
Checksum:iC432C3D4C35CDCA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86228.1.
PIRiT20426.
RefSeqiNP_497811.1. NM_065410.1.
UniGeneiCel.10649.

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943.
GeneIDi184005.
KEGGicel:CELE_E03A3.3.
UCSCiE03A3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86228.1.
PIRiT20426.
RefSeqiNP_497811.1. NM_065410.1.
UniGeneiCel.10649.

3D structure databases

ProteinModelPortaliQ27489.
SMRiQ27489. Positions 4-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48808. 2 interactions.
STRINGi6239.E03A3.3.

Proteomic databases

PaxDbiQ27489.
PRIDEiQ27489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943.
GeneIDi184005.
KEGGicel:CELE_E03A3.3.
UCSCiE03A3.3. c. elegans.

Organism-specific databases

CTDi184005.
WormBaseiE03A3.3; CE00942; WBGene00001943; his-69.

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27489.
KOiK11253.
OMAiPRMGERN.
PhylomeDBiQ27489.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions."
    Simmer F., Moorman C., van der Linden A.M., Kuijk E., van den Berghe P.V.E., Kamath R.S., Fraser A.G., Ahringer J., Plasterk R.H.A.
    PLoS Biol. 1:E12-E12(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  3. "Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans."
    Ooi S.L., Priess J.R., Henikoff S.
    PLoS Genet. 2:883-895(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH33L3_CAEEL
AccessioniPrimary (citable) accession number: Q27489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.