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Protein

Putative histone H3.3-like type 3

Gene

his-69

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone H3.3-like type 3
Gene namesi
Name:his-69
ORF Names:E03A3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiE03A3.3; CE00942; WBGene00001943; his-69.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Disruption phenotypei

Worms exhibit slow postembryonic growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686351 – 127Putative histone H3.3-like type 3Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei19N6-methylated lysineBy similarity1
Modified residuei28N6-methylated lysineBy similarity1
Modified residuei71N6-methylated lysineBy similarity1

Post-translational modificationi

Acetylation is generally linked to gene activation.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ27489.
PeptideAtlasiQ27489.

Expressioni

Gene expression databases

BgeeiWBGene00001943.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi48808. 2 interactors.
STRINGi6239.E03A3.3.

Structurei

3D structure databases

ProteinModelPortaliQ27489.
SMRiQ27489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27489.
KOiK11253.
OMAiPRMGERN.
OrthoDBiEOG091G11DZ.
PhylomeDBiQ27489.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00622. HISTONEH3.
SMARTiView protein in SMART
SM00428. H3. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPGGKAPRK QLATKAARKN AIVVGAVKKP HRFRPGTVAL REIRRYQKST
60 70 80 90 100
DLLLRKLPFQ RLVREIAQDV KQDLRFQSAA IQALQEASEY FLVGLFEDTN
110 120
LCAIHAKRVT IMPKDMQLAR RIRGERN
Length:127
Mass (Da):14,523
Last modified:November 1, 1996 - v1
Checksum:iC432C3D4C35CDCA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86228.1.
PIRiT20426.
RefSeqiNP_497811.1. NM_065410.1.
UniGeneiCel.10649.

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943.
GeneIDi184005.
KEGGicel:CELE_E03A3.3.
UCSCiE03A3.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38112 Genomic DNA. Translation: CAA86228.1.
PIRiT20426.
RefSeqiNP_497811.1. NM_065410.1.
UniGeneiCel.10649.

3D structure databases

ProteinModelPortaliQ27489.
SMRiQ27489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48808. 2 interactors.
STRINGi6239.E03A3.3.

Proteomic databases

PaxDbiQ27489.
PeptideAtlasiQ27489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE03A3.3; E03A3.3; WBGene00001943.
GeneIDi184005.
KEGGicel:CELE_E03A3.3.
UCSCiE03A3.3. c. elegans.

Organism-specific databases

CTDi184005.
WormBaseiE03A3.3; CE00942; WBGene00001943; his-69.

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
InParanoidiQ27489.
KOiK11253.
OMAiPRMGERN.
OrthoDBiEOG091G11DZ.
PhylomeDBiQ27489.

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-5578749. Transcriptional regulation by small RNAs.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Gene expression databases

BgeeiWBGene00001943.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00622. HISTONEH3.
SMARTiView protein in SMART
SM00428. H3. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH33L3_CAEEL
AccessioniPrimary (citable) accession number: Q27489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.