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Q27488

- PSA2_CAEEL

UniProt

Q27488 - PSA2_CAEEL

Protein

Proteasome subunit alpha type-2

Gene

pas-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-2 (EC:3.4.25.1)
    Short name:
    Proteasome subunit alpha 2
    Gene namesi
    Name:pas-2
    ORF Names:D1054.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiD1054.2; CE05521; WBGene00003923; pas-2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Proteasome subunit alpha type-2PRO_0000124082Add
    BLAST

    Proteomic databases

    PaxDbiQ27488.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-318271,EBI-318271
    nsf-1Q943923EBI-318271,EBI-316816
    pas-6O441563EBI-318271,EBI-318264

    Protein-protein interaction databases

    BioGridi44522. 12 interactions.
    IntActiQ27488. 14 interactions.
    MINTiMINT-211461.
    STRINGi6239.D1054.2.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27488.
    SMRiQ27488. Positions 5-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074870.
    HOGENOMiHOG000091085.
    InParanoidiQ27488.
    KOiK02726.
    OMAiWKATALG.
    PhylomeDBiQ27488.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27488-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDHYGFSLT TFSPSGKLMQ IEYALNAVKN GQPSVGLRAK DGVVLATENV    50
    GSVLTDDQPK VEQISKHIGC VYSGMGPDFR ILVKKARKIA MEYEMMYGEE 100
    MPTIQLVTDI AAVMQEYTQS GGVRPFGASL LIAGWDKNPG RPLLFQCDPS 150
    GAYFAWKATA LGKNDVNAKT FLEKRFSEAL ELDDGIHTAL LTLRESFDVG 200
    MNENNVEVAV CNSTGFHRLT KQQVHDHLGT L 231
    Length:231
    Mass (Da):25,336
    Last modified:November 1, 1996 - v1
    Checksum:i78D5F7F61C2E8A3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74030 Genomic DNA. Translation: CAA98441.1.
    PIRiT20304.
    RefSeqiNP_505750.1. NM_073349.6.
    UniGeneiCel.2929.

    Genome annotation databases

    EnsemblMetazoaiD1054.2.1; D1054.2.1; WBGene00003923.
    D1054.2.2; D1054.2.2; WBGene00003923.
    GeneIDi179493.
    KEGGicel:CELE_D1054.2.
    UCSCiD1054.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74030 Genomic DNA. Translation: CAA98441.1 .
    PIRi T20304.
    RefSeqi NP_505750.1. NM_073349.6.
    UniGenei Cel.2929.

    3D structure databases

    ProteinModelPortali Q27488.
    SMRi Q27488. Positions 5-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44522. 12 interactions.
    IntActi Q27488. 14 interactions.
    MINTi MINT-211461.
    STRINGi 6239.D1054.2.1.

    Proteomic databases

    PaxDbi Q27488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai D1054.2.1 ; D1054.2.1 ; WBGene00003923 .
    D1054.2.2 ; D1054.2.2 ; WBGene00003923 .
    GeneIDi 179493.
    KEGGi cel:CELE_D1054.2.
    UCSCi D1054.2.1. c. elegans.

    Organism-specific databases

    CTDi 179493.
    WormBasei D1054.2 ; CE05521 ; WBGene00003923 ; pas-2.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074870.
    HOGENOMi HOG000091085.
    InParanoidi Q27488.
    KOi K02726.
    OMAi WKATALG.
    PhylomeDBi Q27488.

    Enzyme and pathway databases

    Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    NextBioi 905634.
    PROi Q27488.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPSA2_CAEEL
    AccessioniPrimary (citable) accession number: Q27488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3