Reviewed, UniProtKB/Swiss-Prot Q27488 (PSA2_CAEEL)

Names and origin

Protein names

Recommended name:
    Proteasome subunit alpha type-2
      Short name=Proteasome subunit alpha 2
    EC=3.4.25.1

Gene names

Name:	pas-2
ORF Names:	D1054.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Proteasome subunit alpha type-2		PRO_0000124082

Sequences

	Sequence		Length	Mass (Da)
	Q27488-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 78D5F7F61C2E8A3F	FASTA	231	25,336
	10 20 30 40 50 60 MGDHYGFSLT TFSPSGKLMQ IEYALNAVKN GQPSVGLRAK DGVVLATENV GSVLTDDQPK 70 80 90 100 110 120 VEQISKHIGC VYSGMGPDFR ILVKKARKIA MEYEMMYGEE MPTIQLVTDI AAVMQEYTQS 130 140 150 160 170 180 GGVRPFGASL LIAGWDKNPG RPLLFQCDPS GAYFAWKATA LGKNDVNAKT FLEKRFSEAL 190 200 210 220 230 ELDDGIHTAL LTLRESFDVG MNENNVEVAV CNSTGFHRLT KQQVHDHLGT L

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z74030 Genomic DNA. Translation: CAA98441.1.
PIR	T20304.
RefSeq	NP_505750.1.
UniGene	Cel.2929
3D structure databases
HSSP	HSSP built from PDB template 1RYP based on UniProtKB P23639.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q27488. 16 interactions.
STRING	Q27488.
Protein family/group databases
MEROPS	T01.972.
Genome annotation databases
Ensembl	D1054.2.1; D1054.2.1; D1054.2; Caenorhabditis elegans. [Genome view] D1054.2.2; D1054.2.2; D1054.2; Caenorhabditis elegans. [Genome view]
GeneID	179493.
KEGG	cel:D1054.2.
NMPDR	fig|6239.3.peg.19515.
UCSC	D1054.2.1. c. elegans.
Organism-specific databases
CTD	179493.
WormBase	WBGene00003923. pas-2.
WormPep	D1054.2. CE05521. [WorfDB]
Phylogenomic databases
OMA	HIALLTL.
Enzyme and pathway databases
BRENDA	3.4.25.1. 672.
Gene expression databases
ArrayExpress	Q27488.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_CS. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	905634.

Entry information

Entry name

PSA2_CAEEL

Accession

Primary (citable) accession number: Q27488

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project