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Q27488 (PSA2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-2

Short name=Proteasome subunit alpha 2
EC=3.4.25.1
Gene names
Name:pas-2
ORF Names:D1054.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Proteasome subunit alpha type-2
PRO_0000124082

Sequences

Sequence LengthMass (Da)Tools
Q27488 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 78D5F7F61C2E8A3F

FASTA23125,336
        10         20         30         40         50         60 
MGDHYGFSLT TFSPSGKLMQ IEYALNAVKN GQPSVGLRAK DGVVLATENV GSVLTDDQPK 

        70         80         90        100        110        120 
VEQISKHIGC VYSGMGPDFR ILVKKARKIA MEYEMMYGEE MPTIQLVTDI AAVMQEYTQS 

       130        140        150        160        170        180 
GGVRPFGASL LIAGWDKNPG RPLLFQCDPS GAYFAWKATA LGKNDVNAKT FLEKRFSEAL 

       190        200        210        220        230 
ELDDGIHTAL LTLRESFDVG MNENNVEVAV CNSTGFHRLT KQQVHDHLGT L 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z74030 Genomic DNA. Translation: CAA98441.1.
PIRT20304.
RefSeqNP_505750.1. NM_073349.6.
UniGeneCel.2929.

3D structure databases

ProteinModelPortalQ27488.
SMRQ27488. Positions 5-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44522. 12 interactions.
IntActQ27488. 14 interactions.
MINTMINT-211461.
STRING6239.D1054.2.1.

Proteomic databases

PaxDbQ27488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaD1054.2.1; D1054.2.1; WBGene00003923.
D1054.2.2; D1054.2.2; WBGene00003923.
GeneID179493.
KEGGcel:CELE_D1054.2.
UCSCD1054.2.1. c. elegans.

Organism-specific databases

CTD179493.
WormBaseD1054.2; CE05521; WBGene00003923; pas-2.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00550000074870.
HOGENOMHOG000091085.
InParanoidQ27488.
KOK02726.
OMAWKATALG.
PhylomeDBQ27488.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio905634.
PROQ27488.

Entry information

Entry namePSA2_CAEEL
AccessionPrimary (citable) accession number: Q27488
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase