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Protein

Peroxisomal catalase 1

Gene

ctl-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711PROSITE-ProRule annotation
Active sitei144 – 1441PROSITE-ProRule annotation
Metal bindingi354 – 3541Iron (heme axial ligand)By similarity

GO - Molecular functioni

  • catalase activity Source: UniProtKB
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: UniProtKB

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • hydrogen peroxide catabolic process Source: GO_Central
  • peroxisome organization Source: WormBase
  • response to hydrogen peroxide Source: GO_Central
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-74259. Purine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal catalase 1 (EC:1.11.1.6)
Gene namesi
Name:ctl-2
Synonyms:cat, cat-1
ORF Names:Y54G11A.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY54G11A.5; CE22476; WBGene00000831; ctl-2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: GO_Central
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Peroxisomal catalase 1PRO_0000084909Add
BLAST

Proteomic databases

EPDiQ27487.
PaxDbiQ27487.
PeptideAtlasiQ27487.
PRIDEiQ27487.

Expressioni

Developmental stagei

Constant throughout early development and declines as adults age.1 Publication

Gene expression databases

BgeeiWBGene00000831.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y54G11A.5.2.

Structurei

3D structure databases

ProteinModelPortaliQ27487.
SMRiQ27487. Positions 22-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi498 – 5003Microbody targeting signal

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
GeneTreeiENSGT00390000018100.
HOGENOMiHOG000087852.
InParanoidiQ27487.
KOiK03781.
OMAiPRTHIQE.
OrthoDBiEOG091G04V5.
PhylomeDBiQ27487.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD
60 70 80 90 100
VVYMDEMAHF DRERIPERVV HAKGAGAHGY FEVTHDISKY CKADIFNKVG
110 120 130 140 150
KQTPLLIRFS TVGGESGSAD TARDPRGFAI KFYTEEGNWD LVGNNTPIFF
160 170 180 190 200
IRDPIHFPNF IHTQKRNPQT HLKDPNMIFD FWLHRPEALH QVMFLFSDRG
210 220 230 240 250
LPDGYRHMNG YGSHTFKMVN KDGKAIYVKF HFKPTQGVKN LTVEKAGQLA
260 270 280 290 300
SSDPDYSIRD LFNAIEKGDF PVWKMFIQVM TFEQAEKWEF NPFDVTKVWP
310 320 330 340 350
HGDYPLIEVG KMVLNRNPRN YFAEVEQSAF CPAHIVPGIE FSPDKMLQGR
360 370 380 390 400
IFSYTDTHFH RLGPNYIQLP VNCPYRSRAH NTQRDGAMAY DNQQHAPNFF
410 420 430 440 450
PNSFNYGKTR PDVKDTTFPA TGDVDRYESG DDNNYDQPRQ FWEKVLDTGA
460 470 480 490 500
RERMCQNFAG PLGECHDFII KGMIDHFSKV HPDFGARVKA LIQKQARSHI
Length:500
Mass (Da):57,467
Last modified:February 7, 2006 - v3
Checksum:iB9A705148C059034
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3273Missing in CAA74393 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82175 mRNA. Translation: CAA57665.1.
Y14065 Genomic DNA. Translation: CAA74393.1.
AL034488 Genomic DNA. Translation: CAA22451.1.
PIRiT27177.
RefSeqiNP_001022473.1. NM_001027302.5.
UniGeneiCel.13909.

Genome annotation databases

EnsemblMetazoaiY54G11A.5.1; Y54G11A.5.1; WBGene00000831.
Y54G11A.5.2; Y54G11A.5.2; WBGene00000831.
GeneIDi175085.
KEGGicel:CELE_Y54G11A.5.
UCSCiY54G11A.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82175 mRNA. Translation: CAA57665.1.
Y14065 Genomic DNA. Translation: CAA74393.1.
AL034488 Genomic DNA. Translation: CAA22451.1.
PIRiT27177.
RefSeqiNP_001022473.1. NM_001027302.5.
UniGeneiCel.13909.

3D structure databases

ProteinModelPortaliQ27487.
SMRiQ27487. Positions 22-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y54G11A.5.2.

Proteomic databases

EPDiQ27487.
PaxDbiQ27487.
PeptideAtlasiQ27487.
PRIDEiQ27487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY54G11A.5.1; Y54G11A.5.1; WBGene00000831.
Y54G11A.5.2; Y54G11A.5.2; WBGene00000831.
GeneIDi175085.
KEGGicel:CELE_Y54G11A.5.
UCSCiY54G11A.5.1. c. elegans.

Organism-specific databases

CTDi175085.
WormBaseiY54G11A.5; CE22476; WBGene00000831; ctl-2.

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
GeneTreeiENSGT00390000018100.
HOGENOMiHOG000087852.
InParanoidiQ27487.
KOiK03781.
OMAiPRTHIQE.
OrthoDBiEOG091G04V5.
PhylomeDBiQ27487.

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-74259. Purine catabolism.

Miscellaneous databases

PROiQ27487.

Gene expression databases

BgeeiWBGene00000831.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA1_CAEEL
AccessioniPrimary (citable) accession number: Q27487
Secondary accession number(s): O18192, Q9XVZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 7, 2006
Last modified: September 7, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.