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Reviewed, UniProtKB/Swiss-Prot Q27487 (CATA1_CAEEL)

Last modified November 3, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Peroxisomal catalase 1
    EC=1.11.1.6
Gene names
Name: ctl-2
Synonyms: cat, cat-1
ORF Names: Y54G11A.5
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subcellular location

Peroxisome. Ref.1

Developmental stage

Constant throughout early development and declines as adults age. Ref.1

Sequence similarities

Belongs to the catalase family.

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Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentPeroxisome
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdetermination of adult lifespan Ref.1

Inferred from mutant phenotype. Source: UniProtKB

hydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome Ref.1

Inferred from direct assay. Source: UniProtKB

   Molecular functioncatalase activity Ref.1

Inferred from mutant phenotype. Source: UniProtKB

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Peroxisomal catalase 1
PRO_0000084909

Regions

Motif498 – 5003Microbody targeting signal

Sites

Active site711 By similarity
Active site1441 By similarity
Metal binding3541Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict325 – 3273Missing in CAA74393. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q27487-1 [UniParc].

Last modified February 7, 2006. Version 3.
Checksum: B9A705148C059034

FASTA50057,467
        10         20         30         40         50         60 
MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD VVYMDEMAHF 

        70         80         90        100        110        120 
DRERIPERVV HAKGAGAHGY FEVTHDISKY CKADIFNKVG KQTPLLIRFS TVGGESGSAD 

       130        140        150        160        170        180 
TARDPRGFAI KFYTEEGNWD LVGNNTPIFF IRDPIHFPNF IHTQKRNPQT HLKDPNMIFD 

       190        200        210        220        230        240 
FWLHRPEALH QVMFLFSDRG LPDGYRHMNG YGSHTFKMVN KDGKAIYVKF HFKPTQGVKN 

       250        260        270        280        290        300 
LTVEKAGQLA SSDPDYSIRD LFNAIEKGDF PVWKMFIQVM TFEQAEKWEF NPFDVTKVWP 

       310        320        330        340        350        360 
HGDYPLIEVG KMVLNRNPRN YFAEVEQSAF CPAHIVPGIE FSPDKMLQGR IFSYTDTHFH 

       370        380        390        400        410        420 
RLGPNYIQLP VNCPYRSRAH NTQRDGAMAY DNQQHAPNFF PNSFNYGKTR PDVKDTTFPA 

       430        440        450        460        470        480 
TGDVDRYESG DDNNYDQPRQ FWEKVLDTGA RERMCQNFAG PLGECHDFII KGMIDHFSKV 

       490        500 
HPDFGARVKA LIQKQARSHI

« Hide

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References

« Hide 'large scale' references
[1]"A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants."
Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., Chalfie M.
Nature 399:162-166(1999) [PubMed: 10335847] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
Strain: Bristol N2.
[2]Henkle-Duehrsen K.J.
Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[3]Eckelt V.H.O.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[4]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X82175 mRNA. Translation: CAA57665.1.
Y14065 Genomic DNA. Translation: CAA74393.1.
AL034488 Genomic DNA. Translation: CAA22451.1.
PIRT27177.
RefSeqNP_001022473.1.
UniGeneCel.13909

3D structure databases

HSSPHSSP built from PDB template 4BLC based on UniProtKB P00432.
ModBaseSearch...

Proteomic databases

PRIDEQ27487.

Genome annotation databases

EnsemblY54G11A.5.1; Y54G11A.5.1; Y54G11A.5; Caenorhabditis elegans. [Genome view]
Y54G11A.5.2; Y54G11A.5.2; Y54G11A.5; Caenorhabditis elegans. [Genome view]
GeneID175085.
KEGGcel:Y54G11A.5.
UCSCY54G11A.5.1. c. elegans.

Organism-specific databases

CTD175085.
WormBaseWBGene00000831. ctl-2.
WormPepY54G11A.5. CE22476. [WorfDB]

Phylogenomic databases

OMANIARHIN.

Enzyme and pathway databases

BRENDA1.11.1.6. 672.

Gene expression databases

ArrayExpressQ27487.

Family and domain databases

InterProIPR002226. Catalase.
IPR010582. Catalase-rel_immune_responsive.
IPR011614. Catalase_N.
IPR018028. Catalase_rel_subgroup.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PRINTSPR00067. CATALASE.
ProDomPD000510. Catalase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio886688.

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Entry information

Entry nameCATA1_CAEEL
AccessionPrimary (citable) accession number: Q27487
Secondary accession number(s): O18192, Q9XVZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 7, 2006
Last modified: November 3, 2009
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents