Q27487 (CATA1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal catalase 1
EC=1.11.1.6

Gene names

Name:	ctl-2
Synonyms:	cat, cat-1
ORF Names:	Y54G11A.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subcellular location	Peroxisome Ref.1.
Developmental stage	Constant throughout early development and declines as adults age. Ref.1
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype Ref.1. Source: UniProtKB hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW peroxisome organization Inferred from mutant phenotype. Source: WormBase
Cellular component	peroxisome Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	catalase activity Inferred from mutant phenotype Ref.1. Source: UniProtKB heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Peroxisomal catalase 1		PRO_0000084909
Regions
	Motif	498 – 500	3	Microbody targeting signal
Sites
	Active site	71	1	By similarity
	Active site	144	1	By similarity
	Metal binding	354	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	325 – 327	3	Missing in CAA74393. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q27487 [UniParc]. Last modified February 7, 2006. Version 3. Checksum: B9A705148C059034	FASTA	500	57,467
	10 20 30 40 50 60 MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD VVYMDEMAHF 70 80 90 100 110 120 DRERIPERVV HAKGAGAHGY FEVTHDISKY CKADIFNKVG KQTPLLIRFS TVGGESGSAD 130 140 150 160 170 180 TARDPRGFAI KFYTEEGNWD LVGNNTPIFF IRDPIHFPNF IHTQKRNPQT HLKDPNMIFD 190 200 210 220 230 240 FWLHRPEALH QVMFLFSDRG LPDGYRHMNG YGSHTFKMVN KDGKAIYVKF HFKPTQGVKN 250 260 270 280 290 300 LTVEKAGQLA SSDPDYSIRD LFNAIEKGDF PVWKMFIQVM TFEQAEKWEF NPFDVTKVWP 310 320 330 340 350 360 HGDYPLIEVG KMVLNRNPRN YFAEVEQSAF CPAHIVPGIE FSPDKMLQGR IFSYTDTHFH 370 380 390 400 410 420 RLGPNYIQLP VNCPYRSRAH NTQRDGAMAY DNQQHAPNFF PNSFNYGKTR PDVKDTTFPA 430 440 450 460 470 480 TGDVDRYESG DDNNYDQPRQ FWEKVLDTGA RERMCQNFAG PLGECHDFII KGMIDHFSKV 490 500 HPDFGARVKA LIQKQARSHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants." Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., Chalfie M. Nature 399:162-166(1999) [PubMed: 10335847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE. Strain: Bristol N2.
[2]	Henkle-Duehrsen K.J. Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[3]	Eckelt V.H.O. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bristol N2.
[4]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82175 mRNA. Translation: CAA57665.1. Y14065 Genomic DNA. Translation: CAA74393.1. AL034488 Genomic DNA. Translation: CAA22451.1.
PIR	T27177.
RefSeq	NP_001022473.1. NM_001027302.4.
UniGene	Cel.13909.
3D structure databases
ProteinModelPortal	Q27487.
SMR	Q27487. Positions 22-494.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27487.
Proteomic databases
PRIDE	Q27487.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y54G11A.5.1; Y54G11A.5.1; Y54G11A.5. Y54G11A.5.2; Y54G11A.5.2; Y54G11A.5.
GeneID	175085.
KEGG	cel:Y54G11A.5.
UCSC	Y54G11A.5.1. c. elegans.
Organism-specific databases
CTD	175085.
WormBase	Y54G11A.5; CE22476; WBGene00000831; ctl-2.
Phylogenomic databases
eggNOG	meNOG06894.
GeneTree	EMGT00050000017475.
HOGENOM	HBG339355.
InParanoid	Q27487.
OMA	DWVYNNT.
PhylomeDB	Q27487.
Gene expression databases
ArrayExpress	Q27487.
Family and domain databases
InterPro	IPR018028. Catalase. IPR020835. Catalase-like_dom. IPR024708. Catalase_AS. IPR024711. Catalase_clade1/3. IPR011614. Catalase_core. IPR002226. Catalase_haem_BS. IPR010582. Catalase_immune_responsive. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
KO	K03781.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PIRSF	PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTS	PR00067. CATALASE.
SMART	SM01060. Catalase. 1 hit. [Graphical view]
SUPFAM	SSF56634. Catalase_N. 1 hit.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	886688.

Entry information

Entry name

CATA1_CAEEL

Accession

Primary (citable) accession number: Q27487
Secondary accession number(s): O18192, Q9XVZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project