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Protein

Histone H2A

Gene

his-35

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-3214858 RMTs methylate histone arginines
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5689880 Ub-specific processing proteases
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-CEL-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:his-35Imported
ORF Names:C50F4.13Imported, CELE_C50F4.13Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC50F4.13 ; CE05477 ; WBGene00001909 ; his-35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ27485
PaxDbiQ27485

Expressioni

Gene expression databases

BgeeiWBGene00001909

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C50F4.13.1

Structurei

3D structure databases

ProteinModelPortaliQ27485
SMRiQ27485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 90HistoneInterPro annotationAdd BLAST82
Domaini93 – 126Histone_H2A_CInterPro annotationAdd BLAST34

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234652
InParanoidiQ27485
KOiK11251
OMAiVIVECAC
OrthoDBiEOG091G0XGD
PhylomeDBiQ27485

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Q27485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKA KTGGKAKSRS SRAGLQFPVG RLHRILRKGN YAQRVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI APRHLQLAVR NDEELNKLLA
110 120
GVTIAQGGVL PNIQAVLLPK KTAGDKE
Length:127
Mass (Da):13,419
Last modified:November 1, 1996 - v1
Checksum:iFBF085558ABBD340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA94747.1
PIRiT20119
RefSeqiNP_505463.1, NM_073062.6
UniGeneiCel.8222

Genome annotation databases

EnsemblMetazoaiC50F4.13.1; C50F4.13.1; WBGene00001909
C50F4.13.2; C50F4.13.2; WBGene00001909
GeneIDi179339
KEGGicel:CELE_C50F4.13
UCSCiC50F4.13.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ27485_CAEEL
AccessioniPrimary (citable) accession number: Q27485
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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