ID   K6PF_CAEEL              Reviewed;         756 AA.
AC   Q27483;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Probable 6-phosphofructokinase;
DE            Short=Phosphofructokinase;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphohexokinase;
GN   ORFNames=C50F4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family. Two domains
CC       subfamily.
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DR   EMBL; Z70750; CAA94737.1; -; Genomic_DNA.
DR   PIR; T20109; T20109.
DR   RefSeq; NP_505457.1; -.
DR   UniGene; Cel.5512; -.
DR   HSSP; P00512; 3PFK.
DR   Ensembl; C50F4.2; Caenorhabditis elegans.
DR   GeneID; 179335; -.
DR   KEGG; cel:C50F4.2; -.
DR   NMPDR; fig|6239.3.peg.19126; -.
DR   WormBase; WBGene00008230; C50F4.2.
DR   WormPep; C50F4.2; CE05467.
DR   OMA; Q27483; ANEGREL.
DR   BRENDA; 2.7.1.11; 672.
DR   NextBio; 904966; -.
DR   ArrayExpress; Q27483; -.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0040018; P:positive regulation of multicellular organi...; IMP:WormBase.
DR   GO; GO:0000003; P:reproduction; IMP:WormBase.
DR   InterPro; IPR009161; 6-phosphofructokinase_euk.
DR   InterPro; IPR000023; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   Pfam; PF00365; PFK; 2.
DR   PIRSF; PIRSF000533; ATP_PFK_euk; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   ProDom; PD000707; Ppfruckinase; 2.
DR   TIGRFAMs; TIGR02478; 6PF1K_euk; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE   2: Evidence at transcript level;
KW   Allosteric enzyme; ATP-binding; Complete proteome; Glycolysis; Kinase;
KW   Nucleotide-binding; Repeat; Transferase.
FT   CHAIN         1    756       Probable 6-phosphofructokinase.
FT                                /FTId=PRO_0000112029.
FT   NP_BIND      30     34       ATP (By similarity).
FT   NP_BIND     186    190       ATP (By similarity).
FT   NP_BIND     203    219       ATP (By similarity).
FT   ACT_SITE    159    159       Proton acceptor (By similarity).
FT   BINDING     194    194       Substrate (By similarity).
FT   BINDING     285    285       Substrate (By similarity).
FT   BINDING     291    291       Substrate (By similarity).
FT   BINDING     294    294       Substrate (By similarity).
SQ   SEQUENCE   756 AA;  83301 MW;  26A89B801D286534 CRC64;
     MEQKFKKGKD HGVGVLTSGG DSQGMNAAVR SVVRETIRQG HRCYLIREGY NGLINGNIEL
     AKWAHVANVT HLGGSMIGTS RCDEFRTTDG RKKAAAIMFD KRIFHLIVIG GDGSLMGAQK
     LKEEWGRFGE ELFAEGKITE EVANEGRELH LAGIVGSIDN DCIESDKSIG SDTALHRICE
     AIDGLVMTAQ SHQRVFVVEV MGRHCGYLAL TAAIAVEADY VFYPEIPPDE KWPEQLCHQL
     GSVRKMGKRQ NVIILGEGVT NSKGQRIDVR QVKEEIETRL QLEVRIATLG HLQRGGAPSF
     LDRLIGLRMG YEAVQEVLKG KEEKEGAVVT GQKTIAKVMC LRGHNIQRNE LSRVIRQTET
     ANEEIMQRHS DLACRLRGFG FLDKQTYLNF VSIPLSTTMP SRTKTFAVVH IGSPCAGMNA
     ATYSFTRMAN HSGIQVIGIK HGWDGLKNKD VKLLTWANVQ GWAQFGGSML GTKRQLPSEM
     DLIAEGLNSN NVDGLVIIGG FMAFESALIL QQNRSEYTCL SIPIVVIPAT ISNNCPGTCM
     SLGVDTALNE ICRQVDNISQ NAIGSKNKVM IIETMGSRSG FLATMTALST GSQFALIRQV
     ETNEKDLEKL AIETKERLDS GNLEKFLLIR SEGASDEIYS PDVKKIFDKV MKNKYGVRIT
     NLGYSQLGGH PSCFDRQMGI RMGVRAFEGI VNPVKMGDRD CCVIGLRGSS LRYVPVQGLG
     KKVCFEHGVP HNMWWLDLHP LVEAMTKKPQ EAVLSS
//