Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

UBA (Human ubiquitin) related

Gene

uba-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • growth Source: WormBase
  • modification-dependent protein catabolic process Source: GO_Central
  • nematode larval development Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • neuromuscular process Source: WormBase
  • oogenesis Source: WormBase
  • protein ubiquitination Source: WormBase
  • spermatogenesis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1169408. ISG15 antiviral mechanism.
R-CEL-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
UBA (Human ubiquitin) relatedImported
Gene namesi
Name:uba-1Imported
ORF Names:C47E12.5Imported, CELE_C47E12.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC47E12.5a; CE05449; WBGene00006699; uba-1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ27481.
PaxDbiQ27481.
PeptideAtlasiQ27481.

Expressioni

Gene expression databases

BgeeiWBGene00006699.
ExpressionAtlasiQ27481. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-25466N.
MINTiMINT-1110667.
STRINGi6239.C47E12.5a.2.

Structurei

3D structure databases

ProteinModelPortaliQ27481.
SMRiQ27481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini983 – 1109UBA_e1_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2012. Eukaryota.
COG0476. LUCA.
GeneTreeiENSGT00390000016689.
HOGENOMiHOG000167329.
InParanoidiQ27481.
OMAiQINDICH.
OrthoDBiEOG091G0130.
PhylomeDBiQ27481.

Family and domain databases

Gene3Di1.10.3240.10. 2 hits.
3.40.50.720. 4 hits.
InterProiIPR032420. E1_4HB.
IPR032418. E1_FCCH.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
IPR018965. Ub-activating_enz_E1_C.
IPR019572. UBA_E1_Cys.
IPR018075. UBQ-activ_enz_E1.
IPR033127. UBQ-activ_enz_E1_Cys_AS.
IPR000011. UBQ/SUMO-activ_enz_E1-like.
[Graphical view]
PfamiPF16191. E1_4HB. 1 hit.
PF16190. E1_FCCH. 1 hit.
PF09358. E1_UFD. 1 hit.
PF00899. ThiF. 2 hits.
PF10585. UBA_e1_thiolCys. 1 hit.
[Graphical view]
PRINTSiPR01849. UBIQUITINACT.
SMARTiSM00985. UBA_e1_C. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01408. Ube1. 1 hit.
PROSITEiPS00865. UBIQUITIN_ACTIVAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTILELTSA NKTNNKATNN KLQREGENEY PPAKRSKTDD EEEPTVVGNG
60 70 80 90 100
TIVGAPKQQT LSGVNQSGNV NVETTKNTEG QDGEKMDTSN NAGGVGGNSD
110 120 130 140 150
ELLDKNLYSR QIYTLGESAM VNLRTASVLI SGLGSVGVEI AKNLILGGVR
160 170 180 190 200
HVTIHDTKLA KWSDLSAQYY LRDADVGHNR ATSCYERLAE LNDSVNVQVS
210 220 230 240 250
TDELTEEFVK TFDLVVLTDA ARTAQRQIAA WTRAHNRRIL ITDARGVFSY
260 270 280 290 300
IFNDFGDNFR IDDATGEQVR EFFIEHIDKT TGEVTTLENL FHGLEDGDHV
310 320 330 340 350
TFSEVKGLTE INGCEPLKIT VKNASKFNIG DFAVSFSDYK EGGRCRQVKV
360 370 380 390 400
PTSVSHVPFE KSLVEPEFGI WDYAKFEYPS QLHALWTALY AFEEKYGRSP
410 420 430 440 450
APRSTQDAAL LKELIPSGTE EIPEKLIELF SFSASGNLVT VSSVVGGIAA
460 470 480 490 500
QEAMKGVTHH MTPLKQWLHL DHVEVLPGDW TSFDNSKLSE TDCQPRQSRY
510 520 530 540 550
DGQAAVFGWP YQECLFRQRW FVVGAGAIGC ELLKNLSMMG VACGEGGLIK
560 570 580 590 600
ITDMDQIEIS NLNRQFLFRR RDVGGKKSEC AARAVTAFNS DVRIEALAER
610 620 630 640 650
VGLETEHIFN DEFFGELNGV ANALDNVDAR RYMDRRCVYY RLPLLESGTM
660 670 680 690 700
GTKGNTQVVY PYLTESYSSS VDPPEKEIPV CTLKNFPNEI QHTIQWAREQ
710 720 730 740 750
FETFFAQPGE MANKFLSDER GFNEHVDKLI SGQQIDILQK VKDALIDARP
760 770 780 790 800
SSAEDCIRWA RNQFQELYHN NIAQMLHSFP PDQLTDSGAK FWSGAKRCPH
810 820 830 840 850
VLNFDPSKEE HFNFVFAASI LIAELYGVQP ILDREEVIRV ALSVNPEPFE
860 870 880 890 900
PKSGVKIAVT DAEAKEQNER GASSMIVDDD AAIEALKLKL ATLNVKSTSK
910 920 930 940 950
LNCVDFEKDD DSNHHMEFIT AASNLRAENY DILPADRMRT KQIAGKIIPA
960 970 980 990 1000
IATTTAAVAG LVCIELYKVV DANGIPKTPM ERFKNTFLNL SMPFFSSAEP
1010 1020 1030 1040 1050
IGAPKKTYMD REFTLWDRID VQGPLTLQEF IDNVQNQTGG CEVSMLSAGA
1060 1070 1080 1090 1100
CLLFSFFMNA GKKQERLKTE VKAVYEELLK KSLHPSVHAL VLEPMMSDPD
1110
GEDVEVPYIR YSF
Length:1,113
Mass (Da):124,084
Last modified:November 1, 1996 - v1
Checksum:i8D2198A97E4066CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA93101.1.
PIRiT20004.
RefSeqiNP_001033404.1. NM_001038315.5.
UniGeneiCel.16912.

Genome annotation databases

EnsemblMetazoaiC47E12.5a.1; C47E12.5a.1; WBGene00006699.
C47E12.5a.2; C47E12.5a.2; WBGene00006699.
GeneIDi177855.
UCSCiC47E12.5a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA93101.1.
PIRiT20004.
RefSeqiNP_001033404.1. NM_001038315.5.
UniGeneiCel.16912.

3D structure databases

ProteinModelPortaliQ27481.
SMRiQ27481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25466N.
MINTiMINT-1110667.
STRINGi6239.C47E12.5a.2.

Proteomic databases

EPDiQ27481.
PaxDbiQ27481.
PeptideAtlasiQ27481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC47E12.5a.1; C47E12.5a.1; WBGene00006699.
C47E12.5a.2; C47E12.5a.2; WBGene00006699.
GeneIDi177855.
UCSCiC47E12.5a.1. c. elegans.

Organism-specific databases

CTDi177855.
WormBaseiC47E12.5a; CE05449; WBGene00006699; uba-1.

Phylogenomic databases

eggNOGiKOG2012. Eukaryota.
COG0476. LUCA.
GeneTreeiENSGT00390000016689.
HOGENOMiHOG000167329.
InParanoidiQ27481.
OMAiQINDICH.
OrthoDBiEOG091G0130.
PhylomeDBiQ27481.

Enzyme and pathway databases

ReactomeiR-CEL-1169408. ISG15 antiviral mechanism.
R-CEL-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiWBGene00006699.
ExpressionAtlasiQ27481. baseline and differential.

Family and domain databases

Gene3Di1.10.3240.10. 2 hits.
3.40.50.720. 4 hits.
InterProiIPR032420. E1_4HB.
IPR032418. E1_FCCH.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
IPR018965. Ub-activating_enz_E1_C.
IPR019572. UBA_E1_Cys.
IPR018075. UBQ-activ_enz_E1.
IPR033127. UBQ-activ_enz_E1_Cys_AS.
IPR000011. UBQ/SUMO-activ_enz_E1-like.
[Graphical view]
PfamiPF16191. E1_4HB. 1 hit.
PF16190. E1_FCCH. 1 hit.
PF09358. E1_UFD. 1 hit.
PF00899. ThiF. 2 hits.
PF10585. UBA_e1_thiolCys. 1 hit.
[Graphical view]
PRINTSiPR01849. UBIQUITINACT.
SMARTiSM00985. UBA_e1_C. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01408. Ube1. 1 hit.
PROSITEiPS00865. UBIQUITIN_ACTIVAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27481_CAEEL
AccessioniPrimary (citable) accession number: Q27481
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.