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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-25a4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-25a4Imported
Synonyms:cyp-25A4Imported
ORF Names:C36A4.6Imported, CELE_C36A4.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC36A4.6; CE03074; WBGene00007967; cyp-25A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2217HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ27479.
PaxDbiQ27479.
PRIDEiQ27479.

Interactioni

Protein-protein interaction databases

STRINGi6239.C36A4.6.

Structurei

3D structure databases

ProteinModelPortaliQ27479.
SMRiQ27479. Positions 25-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000021810.
InParanoidiQ27479.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ27479.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILIISTIF FTIITFISYS IWRRHAIFKL RSSIGIPGPP VHWLWGNLNI
60 70 80 90 100
IKDRVSRLGY NDTTQWHPTL HTKYGPIFGL YCGTQLHITV SEEEDIKEIF
110 120 130 140 150
IQNFSNFSDR MTPDIFGMNQ LNQSLLQNTY ATGWKHTRSA IAPIFSTGKM
160 170 180 190 200
KAMHETLVSK IDIFLEVLKE KSSSGQKWDI FENFQSLSLD IIGKCAFAID
210 220 230 240 250
SNCQRDRTDL FYVQARKFVG AVDLKKSWIL PVSLILPELS WLWRFLYKFS
260 270 280 290 300
DLSAAELPLV KGLVDLYDRR RAGEGGNDST DLLNLLIRRE TIGKMTQREV
310 320 330 340 350
IENCFAFLIA GYETTSTAMM FSAYLLAEYP IVQQKLYEEI KKTKENAGLN
360 370 380 390 400
YDSIHNMKYL DCVYKESLRF YPPTTHFTNR VCLNDMTIRG QIYPEDSTLK
410 420 430 440 450
VQPYTIHRNP ANWESPDEFQ PERFENWEEK SSSLKWIPFG VGPRYCVGMR
460 470 480 490 500
FAEMEFKTTI AKLLDTFELS LVPGDPPMIP ETNGVIFRPR SPVRLNLKLR

I
Length:501
Mass (Da):57,987
Last modified:November 1, 1996 - v1
Checksum:i3454A6051687EFEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91272.1.
PIRiT19766.
RefSeqiNP_497779.1. NM_065378.1.
UniGeneiCel.10739.

Genome annotation databases

EnsemblMetazoaiC36A4.6; C36A4.6; WBGene00007967.
GeneIDi183248.
KEGGicel:CELE_C36A4.6.
UCSCiC36A4.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91272.1.
PIRiT19766.
RefSeqiNP_497779.1. NM_065378.1.
UniGeneiCel.10739.

3D structure databases

ProteinModelPortaliQ27479.
SMRiQ27479. Positions 25-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C36A4.6.

Proteomic databases

EPDiQ27479.
PaxDbiQ27479.
PRIDEiQ27479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC36A4.6; C36A4.6; WBGene00007967.
GeneIDi183248.
KEGGicel:CELE_C36A4.6.
UCSCiC36A4.6. c. elegans.

Organism-specific databases

CTDi183248.
WormBaseiC36A4.6; CE03074; WBGene00007967; cyp-25A4.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000021810.
InParanoidiQ27479.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ27479.

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27479_CAEEL
AccessioniPrimary (citable) accession number: Q27479
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.