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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-25a1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211958. Miscellaneous substrates.
R-CEL-211979. Eicosanoids.
R-CEL-211981. Xenobiotics.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-25a1Imported
Synonyms:cyp-25A1Imported
ORF Names:C36A4.1Imported, CELE_C36A4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC36A4.1; CE43488; WBGene00007963; cyp-25A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ27477.
PaxDbiQ27477.
PeptideAtlasiQ27477.

Expressioni

Gene expression databases

BgeeiWBGene00007963.

Interactioni

Protein-protein interaction databases

STRINGi6239.C36A4.1.

Structurei

3D structure databases

ProteinModelPortaliQ27477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000021810.
InParanoidiQ27477.
OMAiCREDITI.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ27477.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLILSSLV ISIFTFFIYI ILARRERFKL REKIGLSGPE PHWFLGNLKQ
60 70 80 90 100
TAERKEKLGY DDANRWFNEL HEQYGETFGI YYGSQMNIVI SNEKDIKEVF
110 120 130 140 150
IKNFSNFSDR SVPSIYEANQ LTASLLMNSY SSGWKHTRSA IAPIFSTGKM
160 170 180 190 200
KAMQETINSK VDLFLDILRE KASSGQKWDI YDDFQGLTLD VIGKCAFAID
210 220 230 240 250
SNCQRDRNDV FYVNAKKYIS NIDIRHSKII AASVLLPELS TFWKALYKYT
260 270 280 290 300
PLADAEIPLV EGLSNVYERR RGGEGSDSVD LLKLLLNRED DKSKPMTKQE
310 320 330 340 350
VIENCFAFLL AGYETTSTAM TYCSYLLSKY PNVQQKLYEE IMEAKENGGL
360 370 380 390 400
TYDSIHNMKY LDCVYKETLR FYPPVIHFIR RLCREDITIR GQFYPKGAIV
410 420 430 440 450
VCLPHTVHRN PENWDSPEEF HPERFENWEE KSSSLKWIPF GVGPRYCVGM
460 470 480 490 500
RFAEMEFKTT IVKLLDTFEL KQFEGEADLI PDCNGVIMRP NDPVRLHLKP

RN
Length:502
Mass (Da):58,178
Last modified:May 5, 2009 - v3
Checksum:i037DCE0C55C9ABB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91268.3.
RefSeqiNP_497775.3. NM_065374.4.
UniGeneiCel.10741.

Genome annotation databases

EnsemblMetazoaiC36A4.1; C36A4.1; WBGene00007963.
GeneIDi183247.
KEGGicel:CELE_C36A4.1.
UCSCiC36A4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91268.3.
RefSeqiNP_497775.3. NM_065374.4.
UniGeneiCel.10741.

3D structure databases

ProteinModelPortaliQ27477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C36A4.1.

Proteomic databases

EPDiQ27477.
PaxDbiQ27477.
PeptideAtlasiQ27477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC36A4.1; C36A4.1; WBGene00007963.
GeneIDi183247.
KEGGicel:CELE_C36A4.1.
UCSCiC36A4.1. c. elegans.

Organism-specific databases

CTDi183247.
WormBaseiC36A4.1; CE43488; WBGene00007963; cyp-25A1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000021810.
InParanoidiQ27477.
OMAiCREDITI.
OrthoDBiEOG091G0JNC.
PhylomeDBiQ27477.

Enzyme and pathway databases

ReactomeiR-CEL-211958. Miscellaneous substrates.
R-CEL-211979. Eicosanoids.
R-CEL-211981. Xenobiotics.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-CEL-5423646. Aflatoxin activation and detoxification.

Gene expression databases

BgeeiWBGene00007963.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27477_CAEEL
AccessioniPrimary (citable) accession number: Q27477
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.