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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-33b1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-33b1Imported
Synonyms:cyp-33B1Imported
ORF Names:C25E10.2Imported, CELE_C25E10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC25E10.2; CE35248; WBGene00016092; cyp-33B1.

PTM / Processingi

Proteomic databases

PaxDbiQ27471.
PRIDEiQ27471.

Interactioni

Protein-protein interaction databases

DIPiDIP-26783N.
MINTiMINT-1111524.
STRINGi6239.C25E10.2.

Structurei

3D structure databases

ProteinModelPortaliQ27471.
SMRiQ27471. Positions 26-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27471.
KOiK17955.
OMAiDYQDIKE.
OrthoDBiEOG7SN8C8.
PhylomeDBiQ27471.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILIFFALCT LFFLIHQYLW RRRGLPPGPT PIPIFGNLFQ LSGSEAPGIS
60 70 80 90 100
IFQKWKDQYG PIFTFYMGPV PFVVLTDYQD IKETVIKDGD TYADKYLSPE
110 120 130 140 150
FNKYFRGGEY GIMDISGDRW KEHRKFAVLQ LRELGVGKPL MESKILIEAE
160 170 180 190 200
ELIKKLKTAE ILNEDFLLQS ELDVAVGSVI NQFLFGYRFD RSKLFEFTRI
210 220 230 240 250
KTLVNNFMEE VGKPLGVLAF TCHGIPSFLV KLMVSGIEEQ KRELFRFLRK
260 270 280 290 300
QIDGAKSQIN YEEEHNEDFV EAYLRKKFQR EQKNDFDSYC DSQLENVCFD
310 320 330 340 350
IWAAGFDTLT NTVGFLIAYA INYPEMQMLI HQEIDNYLAH HSRLLTLADK
360 370 380 390 400
NALVYFNAFA NEAQRVSNIL PMNLPHALTR DVKLKGYHLK KGTGVIHQIA
410 420 430 440 450
NVMTDETIFK DSQRFDPNRF IDENGKLKKI EELCPFSMGK RQCIGEGLAR
460 470 480 490
MEIFLLAANL FNYFEFLPAS DGLPSLYKDF SLVSHVIPYK CRQYIP
Length:496
Mass (Da):57,456
Last modified:October 1, 2003 - v2
Checksum:iFF9FF6B9992DA4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD65646.1.
PIRiT15606.
RefSeqiNP_505342.2. NM_072941.2.
UniGeneiCel.4675.

Genome annotation databases

EnsemblMetazoaiC25E10.2; C25E10.2; WBGene00016092.
GeneIDi182888.
KEGGicel:CELE_C25E10.2.
UCSCiC25E10.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD65646.1.
PIRiT15606.
RefSeqiNP_505342.2. NM_072941.2.
UniGeneiCel.4675.

3D structure databases

ProteinModelPortaliQ27471.
SMRiQ27471. Positions 26-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26783N.
MINTiMINT-1111524.
STRINGi6239.C25E10.2.

Proteomic databases

PaxDbiQ27471.
PRIDEiQ27471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC25E10.2; C25E10.2; WBGene00016092.
GeneIDi182888.
KEGGicel:CELE_C25E10.2.
UCSCiC25E10.2. c. elegans.

Organism-specific databases

CTDi182888.
WormBaseiC25E10.2; CE35248; WBGene00016092; cyp-33B1.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27471.
KOiK17955.
OMAiDYQDIKE.
OrthoDBiEOG7SN8C8.
PhylomeDBiQ27471.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi919194.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27471_CAEEL
AccessioniPrimary (citable) accession number: Q27471
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.