ID   Q27470_CAEEL            Unreviewed;       492 AA.
AC   Q27470;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 167.
DE   SubName: Full=CYtochrome P450 family {ECO:0000313|EMBL:CCD64274.1};
GN   Name=cyp-33a1 {ECO:0000313|WormBase:C12D5.7};
GN   Synonyms=cyp-33A1 {ECO:0000313|EMBL:CCD64274.1};
GN   ORFNames=C12D5.7 {ECO:0000313|WormBase:C12D5.7}, CELE_C12D5.7
GN   {ECO:0000313|EMBL:CCD64274.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64274.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD64274.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64274.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; BX284605; CCD64274.1; -; Genomic_DNA.
DR   PIR; T30066; T30066.
DR   RefSeq; NP_504988.1; NM_072587.4.
DR   AlphaFoldDB; Q27470; -.
DR   SMR; Q27470; -.
DR   STRING; 6239.C12D5.7.1; -.
DR   EPD; Q27470; -.
DR   PaxDb; 6239-C12D5-7; -.
DR   PeptideAtlas; Q27470; -.
DR   EnsemblMetazoa; C12D5.7.1; C12D5.7.1; WBGene00015709.
DR   GeneID; 179148; -.
DR   KEGG; cel:CELE_C12D5.7; -.
DR   UCSC; C12D5.7; c. elegans.
DR   AGR; WB:WBGene00015709; -.
DR   WormBase; C12D5.7; CE06809; WBGene00015709; cyp-33A1.
DR   eggNOG; KOG0156; Eukaryota.
DR   GeneTree; ENSGT00970000195868; -.
DR   HOGENOM; CLU_001570_22_3_1; -.
DR   InParanoid; Q27470; -.
DR   OMA; NMCFDMW; -.
DR   OrthoDB; 2900138at2759; -.
DR   PhylomeDB; Q27470; -.
DR   Reactome; R-CEL-211958; Miscellaneous substrates.
DR   Reactome; R-CEL-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00015709; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR   GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
DR   GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR   CDD; cd20617; CYP1_2-like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR   PANTHER; PTHR24300:SF181; CYTOCHROME P450 FAMILY; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW   Metal-binding {ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW   ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Proteomics identification {ECO:0007829|EPD:Q27470,
KW   ECO:0007829|PeptideAtlas:Q27470};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
SQ   SEQUENCE   492 AA;  56770 MW;  52B71FE98F0B06C4 CRC64;
     MIFFLLLTAF VLYLFNEFYW KRRGLPPGPI PLPIIGNMIE LFSYPPPTAA YDAWTKKFGK
     IYTVWMGTDP AVIITGYKEL KDTFVNDGHS YLDKMIYSKL NTSLRGGDYG VIDTNGNTWK
     EHRKFALHTL RDFGMGKEAM EASIQLEVDK IDEELKKVEG KEVNIQEHFD LAIGNIINQF
     LFGNRFKDSS KFNELKKLLD LFFEVQGSLR VYFAYTVDFL PQWMVELLTP DVSRVRDGIY
     QFFDEQIEEH RQEIDFETSD SKDYVETFMK EQKKREAEGD FASFSNEQLK NMCFDMWVAG
     MHTTTNTMGF LTAFALNNMD AQRKMQKELT EVIGDRVVTM KDKLNLPYTN AFINEAQRCA
     NLVPMNLPHA VTRDVQLLGC TIPKGTTVIH QISSVMSDPE IFEEPERFVP ERYLDESGNL
     KKIEELVPFS IGKRVCLGEG LARMELFLFT ANSFNRYEFN CGSNGVPSLE RTFAFIAKAQ
     DYTCQVKPRY SS
//