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Q27470

- Q27470_CAEEL

UniProt

Q27470 - Q27470_CAEEL

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Protein
Submitted name:

Protein CYP-33A1

Gene

cyp-33a1

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_104244. Androgen biosynthesis.
REACT_183198. PPARA activates gene expression.
REACT_230635. Endogenous sterols.
REACT_233130. Mineralocorticoid biosynthesis.
REACT_235031. Glucocorticoid biosynthesis.
REACT_238303. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_241876. Methylation.
REACT_249452. Xenobiotics.
REACT_254239. Aflatoxin activation and detoxification.
REACT_258653. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_263534. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein CYP-33A1Imported
Gene namesi
Name:cyp-33a1Imported
Synonyms:cyp-33A1Imported
ORF Names:C12D5.7Imported, CELE_C12D5.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiC12D5.7; CE06809; WBGene00015709; cyp-33A1.

PTM / Processingi

Proteomic databases

PaxDbiQ27470.
PRIDEiQ27470.

Structurei

3D structure databases

ProteinModelPortaliQ27470.
SMRiQ27470. Positions 25-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27470.
KOiK17955.
OMAiWYLATIV.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ27470.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFFLLLTAF VLYLFNEFYW KRRGLPPGPI PLPIIGNMIE LFSYPPPTAA
60 70 80 90 100
YDAWTKKFGK IYTVWMGTDP AVIITGYKEL KDTFVNDGHS YLDKMIYSKL
110 120 130 140 150
NTSLRGGDYG VIDTNGNTWK EHRKFALHTL RDFGMGKEAM EASIQLEVDK
160 170 180 190 200
IDEELKKVEG KEVNIQEHFD LAIGNIINQF LFGNRFKDSS KFNELKKLLD
210 220 230 240 250
LFFEVQGSLR VYFAYTVDFL PQWMVELLTP DVSRVRDGIY QFFDEQIEEH
260 270 280 290 300
RQEIDFETSD SKDYVETFMK EQKKREAEGD FASFSNEQLK NMCFDMWVAG
310 320 330 340 350
MHTTTNTMGF LTAFALNNMD AQRKMQKELT EVIGDRVVTM KDKLNLPYTN
360 370 380 390 400
AFINEAQRCA NLVPMNLPHA VTRDVQLLGC TIPKGTTVIH QISSVMSDPE
410 420 430 440 450
IFEEPERFVP ERYLDESGNL KKIEELVPFS IGKRVCLGEG LARMELFLFT
460 470 480 490
ANSFNRYEFN CGSNGVPSLE RTFAFIAKAQ DYTCQVKPRY SS
Length:492
Mass (Da):56,770
Last modified:November 1, 1996 - v1
Checksum:i52B71FE98F0B06C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080511 Genomic DNA. Translation: CCD64274.1.
PIRiT30066.
RefSeqiNP_504988.1. NM_072587.4.
UniGeneiCel.4827.

Genome annotation databases

EnsemblMetazoaiC12D5.7; C12D5.7; WBGene00015709.
GeneIDi179148.
KEGGicel:CELE_C12D5.7.
UCSCiC12D5.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080511 Genomic DNA. Translation: CCD64274.1 .
PIRi T30066.
RefSeqi NP_504988.1. NM_072587.4.
UniGenei Cel.4827.

3D structure databases

ProteinModelPortali Q27470.
SMRi Q27470. Positions 25-459.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q27470.
PRIDEi Q27470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C12D5.7 ; C12D5.7 ; WBGene00015709 .
GeneIDi 179148.
KEGGi cel:CELE_C12D5.7.
UCSCi C12D5.7. c. elegans.

Organism-specific databases

CTDi 179148.
WormBasei C12D5.7 ; CE06809 ; WBGene00015709 ; cyp-33A1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036993.
InParanoidi Q27470.
KOi K17955.
OMAi WYLATIV.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q27470.

Enzyme and pathway databases

Reactomei REACT_104244. Androgen biosynthesis.
REACT_183198. PPARA activates gene expression.
REACT_230635. Endogenous sterols.
REACT_233130. Mineralocorticoid biosynthesis.
REACT_235031. Glucocorticoid biosynthesis.
REACT_238303. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_241876. Methylation.
REACT_249452. Xenobiotics.
REACT_254239. Aflatoxin activation and detoxification.
REACT_258653. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_263534. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.

Miscellaneous databases

NextBioi 904120.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27470_CAEEL
AccessioniPrimary (citable) accession number: Q27470
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3