Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-23a1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-23a1Imported
Synonyms:cyp-23A1Imported
ORF Names:B0304.3Imported, CELE_B0304.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiB0304.3; CE27050; WBGene00015135; cyp-23A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2519HelicalSequence analysisAdd
BLAST
Transmembranei31 – 4717HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ27465.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0304.3.

Structurei

3D structure databases

ProteinModelPortaliQ27465.
SMRiQ27465. Positions 77-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27465.
KOiK17946.
OMAiSCKITRR.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ27465.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLRNAILL TIATTFLYFR IMRTLNFDNY MATYIYFLTC ITLYAIYELN
60 70 80 90 100
YKRRRLPNGP VPWLVAGNMP SFINVNNVDV LFQSWKQQYG GIFTVWIGPI
110 120 130 140 150
PLVMVSDLPT IKKYFIQHAD SFSNRWRNFV TDSIMEGSNG IVQIDGNKWR
160 170 180 190 200
EQRRFALHTL RDFGVGKPLM EQMITLEVTS LMNHMEKSCG LDGKELHLCP
210 220 230 240 250
SIAVCVGNII NNMLFGLRFN QDNSYMHRLH QLLDDQSHTV MQPIMGAYIA
260 270 280 290 300
FPVTSKIPII NGEWNRLMGI KNELLEFLET QIEGHRMNWK DEMIEQEPED
310 320 330 340 350
LTYAYMIEVE KRKRNGEDVG FFDDQQLKML LLDLFFAGME TTVTTLKWAF
360 370 380 390 400
LLMAKNQKVQ KNVQAELDSI GQPMIEIQHR TRLPYVQATI NEIQRIANIL
410 420 430 440 450
PINLLRTVAE DIEIDGYNFK KGDLIIPQIS ILMNDPEIFE NPEEFNPSRF
460 470 480 490 500
LDEDNNVKKI DEFLPFSIGR RQCLGESLAR AELYLVFANL IQNFNFEVAD
510 520 530
DVTTERVLGL TVSPVEYSCK ITRRGLDHNQ NSVK
Length:534
Mass (Da):61,947
Last modified:June 1, 2001 - v2
Checksum:i8A3C99165F8EBE7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD61735.1.
RefSeqiNP_494797.1. NM_062396.4.
UniGeneiCel.16058.

Genome annotation databases

EnsemblMetazoaiB0304.3; B0304.3; WBGene00015135.
GeneIDi173787.
KEGGicel:CELE_B0304.3.
UCSCiB0304.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD61735.1.
RefSeqiNP_494797.1. NM_062396.4.
UniGeneiCel.16058.

3D structure databases

ProteinModelPortaliQ27465.
SMRiQ27465. Positions 77-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0304.3.

Proteomic databases

PaxDbiQ27465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0304.3; B0304.3; WBGene00015135.
GeneIDi173787.
KEGGicel:CELE_B0304.3.
UCSCiB0304.3. c. elegans.

Organism-specific databases

CTDi173787.
WormBaseiB0304.3; CE27050; WBGene00015135; cyp-23A1.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036993.
InParanoidiQ27465.
KOiK17946.
OMAiSCKITRR.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ27465.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211958. Miscellaneous substrates.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi881099.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ27465_CAEEL
AccessioniPrimary (citable) accession number: Q27465
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.