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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gspd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741NADP 1By similarity
Binding sitei177 – 1771NADP 1; via carbonyl oxygenBy similarity
Binding sitei177 – 1771SubstrateBy similarity
Binding sitei245 – 2451SubstrateBy similarity
Binding sitei264 – 2641SubstrateBy similarity
Active sitei269 – 2691Proton acceptorBy similarity
Binding sitei364 – 3641NADP 2By similarity
Binding sitei367 – 3671SubstrateBy similarity
Binding sitei373 – 3731NADP 2By similarity
Binding sitei377 – 3771NADP 2By similarity
Binding sitei401 – 4011NADP 2By similarity
Binding sitei403 – 4031SubstrateBy similarity
Binding sitei495 – 4951NADP 2By similarity
Binding sitei517 – 5171NADP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478NADP 1By similarity
Nucleotide bindingi409 – 4113NADP 2By similarity
Nucleotide bindingi429 – 4313NADP 2By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. glucose metabolic process Source: UniProtKB-KW
  3. NADP metabolic process Source: UniProtKB
  4. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_302484. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:gspd-1
ORF Names:B0035.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Glucose-6-phosphate 1-dehydrogenasePRO_0000068089Add
BLAST

Proteomic databases

PaxDbiQ27464.
PRIDEiQ27464.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0035.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ27464.
SMRiQ27464. Positions 34-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2115Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000046192.
InParanoidiQ27464.
KOiK00036.
OMAiVEPCTLA.
OrthoDBiEOG7DRJ2T.
PhylomeDBiQ27464.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI
60 70 80 90 100
YPTLWWLFRD NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF
110 120 130 140 150
DDFIKKCSYV QGQYDTSEGF QRLQSSIDDF QKESNNQAVN RLYYLALPPS
160 170 180 190 200
VFNVVSTELK KNCMDHGDSW TRVIIEKPFG HDLKSSCELS THLAKLFKED
210 220 230 240 250
QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM ISFKEDFGTG
260 270 280 290 300
GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA
310 320 330 340 350
AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH
360 370 380 390 400
INNERWEGVP FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM
410 420 430 440 450
RVQPNEAVYM KLMTKKPGMG FGVEETELDL TYNNRFKEVR LPDAYERLFL
460 470 480 490 500
EVFMGSQINF VRTDELEYAW RILTPVLEEL KKKKVQPVQY KFGSRGPTEG
510 520
DELMKKYGFI FTGTYKWVAP KL
Length:522
Mass (Da):60,215
Last modified:November 1, 1996 - v1
Checksum:i7329CC6508B8E378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRiT18657.
RefSeqiNP_502129.1. NM_069728.4.
UniGeneiCel.8269.

Genome annotation databases

EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
GeneIDi178046.
KEGGicel:CELE_B0035.5.
UCSCiB0035.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRiT18657.
RefSeqiNP_502129.1. NM_069728.4.
UniGeneiCel.8269.

3D structure databases

ProteinModelPortaliQ27464.
SMRiQ27464. Positions 34-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0035.5.1.

Proteomic databases

PaxDbiQ27464.
PRIDEiQ27464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
GeneIDi178046.
KEGGicel:CELE_B0035.5.
UCSCiB0035.5.1. c. elegans.

Organism-specific databases

CTDi178046.
WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

Phylogenomic databases

eggNOGiCOG0364.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000046192.
InParanoidiQ27464.
KOiK00036.
OMAiVEPCTLA.
OrthoDBiEOG7DRJ2T.
PhylomeDBiQ27464.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
ReactomeiREACT_302484. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi899498.
PROiQ27464.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiG6PD_CAEEL
AccessioniPrimary (citable) accession number: Q27464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.