Reviewed, UniProtKB/Swiss-Prot Q27464 (G6PD_CAEEL)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	gspd-1
ORF Names:	B0035.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068089
Sites
	Active site	269	1	Proton acceptor By similarity
	Binding site	42	1	NADP By similarity
	Binding site	74	1	NADP By similarity
	Binding site	207	1	Substrate By similarity
	Binding site	211	1	Substrate By similarity
	Binding site	372	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q27464-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7329CC6508B8E378	FASTA	522	60,215
	10 20 30 40 50 60 MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI YPTLWWLFRD 70 80 90 100 110 120 NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF DDFIKKCSYV QGQYDTSEGF 130 140 150 160 170 180 QRLQSSIDDF QKESNNQAVN RLYYLALPPS VFNVVSTELK KNCMDHGDSW TRVIIEKPFG 190 200 210 220 230 240 HDLKSSCELS THLAKLFKED QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM 250 260 270 280 290 300 ISFKEDFGTG GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA 310 320 330 340 350 360 AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH INNERWEGVP 370 380 390 400 410 420 FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM RVQPNEAVYM KLMTKKPGMG 430 440 450 460 470 480 FGVEETELDL TYNNRFKEVR LPDAYERLFL EVFMGSQINF VRTDELEYAW RILTPVLEEL 490 500 510 520 KKKKVQPVQY KFGSRGPTEG DELMKKYGFI FTGTYKWVAP KL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73102 Genomic DNA. Translation: CAA97412.1.
PIR	T18657.
RefSeq	NP_502129.1.
UniGene	Cel.8269
3D structure databases
SMR	Q27464. Positions 34-520.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27464.
Genome annotation databases
Ensembl	B0035.5.1; B0035.5.1; B0035.5; Caenorhabditis elegans. [Genome view] B0035.5.2; B0035.5.2; B0035.5; Caenorhabditis elegans. [Genome view]
GeneID	178046.
KEGG	cel:B0035.5.
UCSC	B0035.5.1. c. elegans.
Organism-specific databases
CTD	178046.
WormBase	WBGene00007108. gspd-1.
WormPep	B0035.5. CE05163. [WorfDB]
Phylogenomic databases
eggNOG	meNOG04006.
HOGENOM	HBG322449.
InParanoid	Q27464.
OMA	TELKKNC.
PhylomeDB	Q27464.
Enzyme and pathway databases
BRENDA	1.1.1.49. 672.
Gene expression databases
ArrayExpress	Q27464.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	899498.

Entry information

Entry name

G6PD_CAEEL

Accession

Primary (citable) accession number: Q27464

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project