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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gspd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gspd-1)
  2. Putative 6-phosphogluconolactonase (Y57G11C.3)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (T25B9.9)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74NADP 1By similarity1
Binding sitei177NADP 1; via carbonyl oxygenBy similarity1
Binding sitei177SubstrateBy similarity1
Binding sitei245SubstrateBy similarity1
Binding sitei264SubstrateBy similarity1
Active sitei269Proton acceptorBy similarity1
Binding sitei364NADP 2By similarity1
Binding sitei367SubstrateBy similarity1
Binding sitei373NADP 2By similarity1
Binding sitei377NADP 2By similarity1
Binding sitei401NADP 2By similarity1
Binding sitei403SubstrateBy similarity1
Binding sitei495NADP 2By similarity1
Binding sitei517NADP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47NADP 1By similarity8
Nucleotide bindingi409 – 411NADP 2By similarity3
Nucleotide bindingi429 – 431NADP 2By similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:gspd-1
ORF Names:B0035.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000680891 – 522Glucose-6-phosphate 1-dehydrogenaseAdd BLAST522

Proteomic databases

EPDiQ27464.
PaxDbiQ27464.
PeptideAtlasiQ27464.
PRIDEiQ27464.

PTM databases

iPTMnetiQ27464.

Expressioni

Gene expression databases

BgeeiWBGene00007108.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0035.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ27464.
SMRiQ27464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 211Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000046192.
InParanoidiQ27464.
KOiK00036.
OMAiFVFRFAN.
OrthoDBiEOG091G06FN.
PhylomeDBiQ27464.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI
60 70 80 90 100
YPTLWWLFRD NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF
110 120 130 140 150
DDFIKKCSYV QGQYDTSEGF QRLQSSIDDF QKESNNQAVN RLYYLALPPS
160 170 180 190 200
VFNVVSTELK KNCMDHGDSW TRVIIEKPFG HDLKSSCELS THLAKLFKED
210 220 230 240 250
QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM ISFKEDFGTG
260 270 280 290 300
GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA
310 320 330 340 350
AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH
360 370 380 390 400
INNERWEGVP FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM
410 420 430 440 450
RVQPNEAVYM KLMTKKPGMG FGVEETELDL TYNNRFKEVR LPDAYERLFL
460 470 480 490 500
EVFMGSQINF VRTDELEYAW RILTPVLEEL KKKKVQPVQY KFGSRGPTEG
510 520
DELMKKYGFI FTGTYKWVAP KL
Length:522
Mass (Da):60,215
Last modified:November 1, 1996 - v1
Checksum:i7329CC6508B8E378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRiT18657.
RefSeqiNP_502129.1. NM_069728.4.
UniGeneiCel.8269.

Genome annotation databases

EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
GeneIDi178046.
KEGGicel:CELE_B0035.5.
UCSCiB0035.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRiT18657.
RefSeqiNP_502129.1. NM_069728.4.
UniGeneiCel.8269.

3D structure databases

ProteinModelPortaliQ27464.
SMRiQ27464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0035.5.1.

PTM databases

iPTMnetiQ27464.

Proteomic databases

EPDiQ27464.
PaxDbiQ27464.
PeptideAtlasiQ27464.
PRIDEiQ27464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
GeneIDi178046.
KEGGicel:CELE_B0035.5.
UCSCiB0035.5.1. c. elegans.

Organism-specific databases

CTDi178046.
WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000046192.
InParanoidiQ27464.
KOiK00036.
OMAiFVFRFAN.
OrthoDBiEOG091G06FN.
PhylomeDBiQ27464.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
ReactomeiR-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiQ27464.

Gene expression databases

BgeeiWBGene00007108.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD_CAEEL
AccessioniPrimary (citable) accession number: Q27464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.