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Q27464

- G6PD_CAEEL

UniProt

Q27464 - G6PD_CAEEL

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
gspd-1, B0035.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741NADP 1 By similarity
Binding sitei177 – 1771NADP 1; via carbonyl oxygen By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei264 – 2641Substrate By similarity
Active sitei269 – 2691Proton acceptor By similarity
Binding sitei364 – 3641NADP 2 By similarity
Binding sitei367 – 3671Substrate By similarity
Binding sitei373 – 3731NADP 2 By similarity
Binding sitei377 – 3771NADP 2 By similarity
Binding sitei401 – 4011NADP 2 By similarity
Binding sitei403 – 4031Substrate By similarity
Binding sitei495 – 4951NADP 2 By similarity
Binding sitei517 – 5171NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478NADP 1 By similarity
Nucleotide bindingi409 – 4113NADP 2 By similarity
Nucleotide bindingi429 – 4313NADP 2 By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. NADP metabolic process Source: UniProtKB
  2. glucose 6-phosphate metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:gspd-1
ORF Names:B0035.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068089Add
BLAST

Proteomic databases

PaxDbiQ27464.
PRIDEiQ27464.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0035.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ27464.
SMRiQ27464. Positions 34-520.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2115Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
GeneTreeiENSGT00530000063435.
HOGENOMiHOG000046192.
InParanoidiQ27464.
KOiK00036.
OMAiFVNNERW.
OrthoDBiEOG7DRJ2T.
PhylomeDBiQ27464.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27464-1 [UniParc]FASTAAdd to Basket

« Hide

MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI    50
YPTLWWLFRD NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF 100
DDFIKKCSYV QGQYDTSEGF QRLQSSIDDF QKESNNQAVN RLYYLALPPS 150
VFNVVSTELK KNCMDHGDSW TRVIIEKPFG HDLKSSCELS THLAKLFKED 200
QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM ISFKEDFGTG 250
GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA 300
AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH 350
INNERWEGVP FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM 400
RVQPNEAVYM KLMTKKPGMG FGVEETELDL TYNNRFKEVR LPDAYERLFL 450
EVFMGSQINF VRTDELEYAW RILTPVLEEL KKKKVQPVQY KFGSRGPTEG 500
DELMKKYGFI FTGTYKWVAP KL 522
Length:522
Mass (Da):60,215
Last modified:November 1, 1996 - v1
Checksum:i7329CC6508B8E378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRiT18657.
RefSeqiNP_502129.1. NM_069728.4.
UniGeneiCel.8269.

Genome annotation databases

EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
GeneIDi178046.
KEGGicel:CELE_B0035.5.
UCSCiB0035.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73102 Genomic DNA. Translation: CAA97412.1 .
PIRi T18657.
RefSeqi NP_502129.1. NM_069728.4.
UniGenei Cel.8269.

3D structure databases

ProteinModelPortali Q27464.
SMRi Q27464. Positions 34-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.B0035.5.1.

Proteomic databases

PaxDbi Q27464.
PRIDEi Q27464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0035.5 ; B0035.5 ; WBGene00007108 .
GeneIDi 178046.
KEGGi cel:CELE_B0035.5.
UCSCi B0035.5.1. c. elegans.

Organism-specific databases

CTDi 178046.
WormBasei B0035.5 ; CE05163 ; WBGene00007108 ; gspd-1.

Phylogenomic databases

eggNOGi COG0364.
GeneTreei ENSGT00530000063435.
HOGENOMi HOG000046192.
InParanoidi Q27464.
KOi K00036.
OMAi FVNNERW.
OrthoDBi EOG7DRJ2T.
PhylomeDBi Q27464.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

NextBioi 899498.
PROi Q27464.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiG6PD_CAEEL
AccessioniPrimary (citable) accession number: Q27464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi