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Q27464

- G6PD_CAEEL

UniProt

Q27464 - G6PD_CAEEL

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gspd-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741NADP 1By similarity
    Binding sitei177 – 1771NADP 1; via carbonyl oxygenBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei245 – 2451SubstrateBy similarity
    Binding sitei264 – 2641SubstrateBy similarity
    Active sitei269 – 2691Proton acceptorBy similarity
    Binding sitei364 – 3641NADP 2By similarity
    Binding sitei367 – 3671SubstrateBy similarity
    Binding sitei373 – 3731NADP 2By similarity
    Binding sitei377 – 3771NADP 2By similarity
    Binding sitei401 – 4011NADP 2By similarity
    Binding sitei403 – 4031SubstrateBy similarity
    Binding sitei495 – 4951NADP 2By similarity
    Binding sitei517 – 5171NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 478NADP 1By similarity
    Nucleotide bindingi409 – 4113NADP 2By similarity
    Nucleotide bindingi429 – 4313NADP 2By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:gspd-1
    ORF Names:B0035.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiB0035.5; CE05163; WBGene00007108; gspd-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Glucose-6-phosphate 1-dehydrogenasePRO_0000068089Add
    BLAST

    Proteomic databases

    PaxDbiQ27464.
    PRIDEiQ27464.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0035.5.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27464.
    SMRiQ27464. Positions 34-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 2115Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    GeneTreeiENSGT00530000063435.
    HOGENOMiHOG000046192.
    InParanoidiQ27464.
    KOiK00036.
    OMAiFVNNERW.
    OrthoDBiEOG7DRJ2T.
    PhylomeDBiQ27464.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27464-1 [UniParc]FASTAAdd to Basket

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    MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI    50
    YPTLWWLFRD NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF 100
    DDFIKKCSYV QGQYDTSEGF QRLQSSIDDF QKESNNQAVN RLYYLALPPS 150
    VFNVVSTELK KNCMDHGDSW TRVIIEKPFG HDLKSSCELS THLAKLFKED 200
    QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM ISFKEDFGTG 250
    GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA 300
    AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH 350
    INNERWEGVP FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM 400
    RVQPNEAVYM KLMTKKPGMG FGVEETELDL TYNNRFKEVR LPDAYERLFL 450
    EVFMGSQINF VRTDELEYAW RILTPVLEEL KKKKVQPVQY KFGSRGPTEG 500
    DELMKKYGFI FTGTYKWVAP KL 522
    Length:522
    Mass (Da):60,215
    Last modified:November 1, 1996 - v1
    Checksum:i7329CC6508B8E378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73102 Genomic DNA. Translation: CAA97412.1.
    PIRiT18657.
    RefSeqiNP_502129.1. NM_069728.4.
    UniGeneiCel.8269.

    Genome annotation databases

    EnsemblMetazoaiB0035.5; B0035.5; WBGene00007108.
    GeneIDi178046.
    KEGGicel:CELE_B0035.5.
    UCSCiB0035.5.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73102 Genomic DNA. Translation: CAA97412.1 .
    PIRi T18657.
    RefSeqi NP_502129.1. NM_069728.4.
    UniGenei Cel.8269.

    3D structure databases

    ProteinModelPortali Q27464.
    SMRi Q27464. Positions 34-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0035.5.1.

    Proteomic databases

    PaxDbi Q27464.
    PRIDEi Q27464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0035.5 ; B0035.5 ; WBGene00007108 .
    GeneIDi 178046.
    KEGGi cel:CELE_B0035.5.
    UCSCi B0035.5.1. c. elegans.

    Organism-specific databases

    CTDi 178046.
    WormBasei B0035.5 ; CE05163 ; WBGene00007108 ; gspd-1.

    Phylogenomic databases

    eggNOGi COG0364.
    GeneTreei ENSGT00530000063435.
    HOGENOMi HOG000046192.
    InParanoidi Q27464.
    KOi K00036.
    OMAi FVNNERW.
    OrthoDBi EOG7DRJ2T.
    PhylomeDBi Q27464.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Miscellaneous databases

    NextBioi 899498.
    PROi Q27464.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiG6PD_CAEEL
    AccessioniPrimary (citable) accession number: Q27464
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3