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Q27464 (G6PD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:gspd-1
ORF Names:B0035.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068089

Regions

Nucleotide binding40 – 478NADP 1 By similarity
Nucleotide binding409 – 4113NADP 2 By similarity
Nucleotide binding429 – 4313NADP 2 By similarity
Region207 – 2115Substrate binding By similarity

Sites

Active site2691Proton acceptor By similarity
Binding site741NADP 1 By similarity
Binding site1771NADP 1; via carbonyl oxygen By similarity
Binding site1771Substrate By similarity
Binding site2451Substrate By similarity
Binding site2641Substrate By similarity
Binding site3641NADP 2 By similarity
Binding site3671Substrate By similarity
Binding site3731NADP 2 By similarity
Binding site3771NADP 2 By similarity
Binding site4011NADP 2 By similarity
Binding site4031Substrate By similarity
Binding site4951NADP 2 By similarity
Binding site5171NADP 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27464 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7329CC6508B8E378

FASTA52260,215
        10         20         30         40         50         60 
MACKRHSVSD PISKDLVECL RESMQRDLKF ETPYVFVIFG ASGDLAKKKI YPTLWWLFRD 

        70         80         90        100        110        120 
NLLPVNIKFI GYARSDLTVF KLRESFEKNC KVRENEKCAF DDFIKKCSYV QGQYDTSEGF 

       130        140        150        160        170        180 
QRLQSSIDDF QKESNNQAVN RLYYLALPPS VFNVVSTELK KNCMDHGDSW TRVIIEKPFG 

       190        200        210        220        230        240 
HDLKSSCELS THLAKLFKED QIYRIDHYLG KEMVQNLMVM RFGNRILAPS WNRDHIASVM 

       250        260        270        280        290        300 
ISFKEDFGTG GRAGYFDTAG IIRDVMQNHL MQILTLVAME KPASLNAEDI RDEKVKVLKA 

       310        320        330        340        350        360 
AKVVELKDVV VGQYIASPEF DHPEASQGYK DDKSVPADST TPTYALAVVH INNERWEGVP 

       370        380        390        400        410        420 
FFLRCGKALN EKKAEVRIQF KEVSGDIYPS GELKRSELVM RVQPNEAVYM KLMTKKPGMG 

       430        440        450        460        470        480 
FGVEETELDL TYNNRFKEVR LPDAYERLFL EVFMGSQINF VRTDELEYAW RILTPVLEEL 

       490        500        510        520 
KKKKVQPVQY KFGSRGPTEG DELMKKYGFI FTGTYKWVAP KL 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73102 Genomic DNA. Translation: CAA97412.1.
PIRT18657.
RefSeqNP_502129.1. NM_069728.4.
UniGeneCel.8269.

3D structure databases

ProteinModelPortalQ27464.
SMRQ27464. Positions 34-520.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.B0035.5.1.

Proteomic databases

PaxDbQ27464.
PRIDEQ27464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0035.5; B0035.5; WBGene00007108.
GeneID178046.
KEGGcel:CELE_B0035.5.
UCSCB0035.5.1. c. elegans.

Organism-specific databases

CTD178046.
WormBaseB0035.5; CE05163; WBGene00007108; gspd-1.

Phylogenomic databases

eggNOGCOG0364.
GeneTreeENSGT00530000063435.
HOGENOMHOG000046192.
InParanoidQ27464.
KOK00036.
OMAFVNNERW.
OrthoDBEOG7DRJ2T.
PhylomeDBQ27464.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio899498.
PROQ27464.

Entry information

Entry nameG6PD_CAEEL
AccessionPrimary (citable) accession number: Q27464
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase