Q27461 (Q27461_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Na,K-ATPase alpha subunit EMBL AAB02615.1

Gene names

Name:

eat-6 EMBL AAB02615.1

Organism

Caenorhabditis elegans EMBL AAB02615.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	996 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Ion transport SAAS SAAS006069 Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS004014
Ligand	ATP-binding SAAS SAAS004014 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS004014
PTM	Phosphoprotein SAAS SAAS004014
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro monovalent inorganic cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27461 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5C27189A83BBD16B	FASTA	996	111,057
	10 20 30 40 50 60 MGKKDKKQEL HDLKQEVKMD EHIVPIEELV ARLGTNLETG LTRQKAQEVL AKNGPNALSP 70 80 90 100 110 120 PETTPEWIKF CKNLFGGFAM LLWVGAILCY IAYSVDYFTM EYPSKDNLYL GIVLMTVVVI 130 140 150 160 170 180 TGVFQYYQES KSSKIMDSFK NMVPTFALVH RDGQKQQVKT EELVVGDIVE VKGGDRVPAD 190 200 210 220 230 240 LRVVSAFGFK VDNSSLTGES EPQSRSPDCT NENPLETRNI AFFSTNAVEG TAKGIVIYTG 250 260 270 280 290 300 DNTVMGRIAH LASGLDTGMT PIAREIEHFI HLITGVAVFL GISFFIIAFI LGYHWLTAVV 310 320 330 340 350 360 FLIGIIVANV PEGLIATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT 370 380 390 400 410 420 QNRMTVAHMW YDETIHECDT TETQTSQEKR TGASFEALVR IASLCNRAEF KAGQQDTPIL 430 440 450 460 470 480 RRDCTGDASE IALLKFTELT QGNVIAVREK NKKIAEIPFN STNKYQVSIH DNGDHYLLVM 490 500 510 520 530 540 KGAPERILDV CSTIFLNGKE SELTDKLRED FNTAYLELGG MGERVLGFCD FVLPADKFPK 550 560 570 580 590 600 GFKFDVEEVN FPLKNLRFVG LMSMIDPPRA AVPDAVAKCR SAGIKVVMVT GDHPITAKAI 610 620 630 640 650 660 AKSVGIISDG TETVEDIAIR RGIPVEEVNP REAKAAVIHG SDLREMSEDQ LAEIIKYHSE 670 680 690 700 710 720 IVFARTSPQQ KLMIVEGFQK QGQIVAVTGD GCNDSPALKK ADIGVAMGIA GSDVSKQAAD 730 740 750 760 770 780 MILLDDNFAS YVVGVEEGRL IFDNLKKSIA YTLTSNIPEI SPFLTYILFG IPLPLGTVTI 790 800 810 820 830 840 LCIDLGTDMV PAISLAYEEA ESDIMKRQPR DPIRDKLVNE RLISLAYGQI GMIQASAGFF 850 860 870 880 890 900 TYFWIMADNG FMPWDLYQLR AQWDSRAYNN VLDSYGQEWT YANRKILEYT CQTAYFVSIV 910 920 930 940 950 960 VVQWADLIIS KTRRNSLVQQ GMSNWTLNFG LVFETALAWF MCYCPGLDNG LRMYGLRFSW 970 980 990 WFCALPFSIL IFVYDEIRRF LIRRYPGGWV ERETYY

References

[1]	"Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function." Davis M.W., Somerville D., Lee R.Y., Lockery S., Avery L., Fambrough D.M. J. Neurosci. 15:8408-8418(1995) [PubMed: 8613772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18546 Genomic DNA. Translation: AAB02615.1.
3D structure databases
HSSP	HSSP built from PDB template 1MO7 based on UniProtKB P06685.
ProteinModelPortal	Q27461.
SMR	Q27461. Positions 6-996.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27461.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	B0365.3.1. c. elegans.
Phylogenomic databases
GeneTree	EMGT00050000001937.
Gene expression databases
ArrayExpress	Q27461.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR005775. ATPase_P-typ_cation-ex_asu_euk. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01106. ATPase-IIC_X-K. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27461_CAEEL

Accession

Primary (citable) accession number: Q27461

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)