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Q27459

- ACE1_CAEBR

UniProt

Q27459 - ACE1_CAEBR

Protein

Acetylcholinesterase 1

Gene

ace-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Rapidly hydrolyzes choline released into the synapse.

    Catalytic activityi

    Acetylcholine + H2O = choline + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei216 – 2161Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei346 – 3461Charge relay systemBy similarity
    Active sitei468 – 4681Charge relay systemBy similarity

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Neurotransmitter degradation

    Protein family/group databases

    MEROPSiS09.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholinesterase 1 (EC:3.1.1.7)
    Short name:
    AChE 1
    Gene namesi
    Name:ace-1
    ORF Names:CBG16374
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG16374; CBP03902; WBGene00036330; Cbr-ace-1.

    Subcellular locationi

    Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity
    Note: May be secreted or membrane associated via a non-catalytic subunit.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 620589Acetylcholinesterase 1PRO_0000008609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi82 ↔ 109By similarity
    Disulfide bondi270 ↔ 286By similarity
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi430 ↔ 558By similarity
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi618 – 618InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Oligomer composed of disulfide-linked homodimers.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG16374.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000091866.
    KOiK01049.
    OMAiSFNAPWA.
    OrthoDBiEOG789C9R.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    ProDomiPD415333. AChE_tetra. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q27459-1 [UniParc]FASTAAdd to Basket

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    MRYSLLFFIF LPCVITAVDL IHLHDGSPLF GEEVLSQTGK PLTRFLGIPF    50
    AEPPIGNLRF RKPKPKQPWR IPFNATTPPN SCIQSEDTYF GDFYGSTMWN 100
    PNTKLSEDCL YLNVYVPGKV DPNKKLAVMI WVYGGGFWSG TSTLDVYDGR 150
    ILTVEENVIL VAMNYRVSIF GFLYMNRSEA PGNMGMWDQL LAMKWVHKNI 200
    DLFGGDTSRI TLFGESAGAA SVSIHMLSQK SAPYFHRAII QSGSATSPWA 250
    IEPRDVALAR AVILYNAMKC GNMSLISPDY DRILDCFQRA DADALRENEW 300
    APVREFGDFP WVPVVDGDFL LENAQTSLKQ GNFKKTQLLA GSNRDESIYF 350
    LTYQLPDIFP VADFFSKSEF IKDRQTWIKG VKDLLPRQIL KCQLTLAAVL 400
    HEYEPQDLPI SAQNWLNAMD KMLGDYHFTC SVNEMALAHT KHGGDTFYYY 450
    FTHRATQQTW PEWMGVLHGY EINFIFGEPF NQKRFNYTDE ERELSNRFMR 500
    YWANFAKTGD PNKNEDGSFT QDIWPKYNSV SMEYMNMTVE SSYPGQNRIG 550
    HGPRRKECAF WKAYLPNLMA AVADVGDPYL VWKQQMDKWQ NEYITDWQYH 600
    FEQYKRYQTY RQSDSETCGG 620
    Length:620
    Mass (Da):71,501
    Last modified:November 1, 1996 - v1
    Checksum:i69D73CD3996E11FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41846 Genomic DNA. Translation: AAB41269.1.
    HE600961 Genomic DNA. Translation: CAP34096.1.
    RefSeqiXP_002643631.1. XM_002643585.1.

    Genome annotation databases

    EnsemblMetazoaiCBG16374; CBG16374; CBG16374.
    GeneIDi8585625.
    KEGGicbr:CBG16374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41846 Genomic DNA. Translation: AAB41269.1 .
    HE600961 Genomic DNA. Translation: CAP34096.1 .
    RefSeqi XP_002643631.1. XM_002643585.1.

    3D structure databases

    ProteinModelPortali Q27459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG16374.

    Protein family/group databases

    MEROPSi S09.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG16374 ; CBG16374 ; CBG16374 .
    GeneIDi 8585625.
    KEGGi cbr:CBG16374.

    Organism-specific databases

    CTDi 8585625.
    WormBasei CBG16374 ; CBP03902 ; WBGene00036330 ; Cbr-ace-1.

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000091866.
    KOi K01049.
    OMAi SFNAPWA.
    OrthoDBi EOG789C9R.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR014788. AChE_tetra.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    ProDomi PD415333. AChE_tetra. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence comparison of ACE-1, the gene encoding acetylcholinesterase of class A, in the two nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
      Grauso M., Culetto E., Berge J.-B., Toutant J.-P., Arpagaus M.
      DNA Seq. 6:217-227(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiACE1_CAEBR
    AccessioniPrimary (citable) accession number: Q27459
    Secondary accession number(s): A8XNK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3