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Protein

Acetylcholinesterase 1

Gene

ace-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Rapidly hydrolyzes choline released into the synapse.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei216 – 2161Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei346 – 3461Charge relay systemBy similarity
Active sitei468 – 4681Charge relay systemBy similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase 1 (EC:3.1.1.7)
Short name:
AChE 1
Gene namesi
Name:ace-1
ORF Names:CBG16374
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG16374; CBP03902; WBGene00036330; Cbr-ace-1.

Subcellular locationi

Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity
Note: May be secreted or membrane associated via a non-catalytic subunit.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 620589Acetylcholinesterase 1PRO_0000008609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi82 ↔ 109By similarity
Disulfide bondi270 ↔ 286By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi430 ↔ 558By similarity
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi618 – 618InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Oligomer composed of disulfide-linked homodimers.By similarity

Protein-protein interaction databases

STRINGi6238.CBG16374.

Structurei

3D structure databases

ProteinModelPortaliQ27459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
HOGENOMiHOG000091866.
InParanoidiQ27459.
KOiK01049.
OMAiSFNAPWA.
OrthoDBiEOG789C9R.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYSLLFFIF LPCVITAVDL IHLHDGSPLF GEEVLSQTGK PLTRFLGIPF
60 70 80 90 100
AEPPIGNLRF RKPKPKQPWR IPFNATTPPN SCIQSEDTYF GDFYGSTMWN
110 120 130 140 150
PNTKLSEDCL YLNVYVPGKV DPNKKLAVMI WVYGGGFWSG TSTLDVYDGR
160 170 180 190 200
ILTVEENVIL VAMNYRVSIF GFLYMNRSEA PGNMGMWDQL LAMKWVHKNI
210 220 230 240 250
DLFGGDTSRI TLFGESAGAA SVSIHMLSQK SAPYFHRAII QSGSATSPWA
260 270 280 290 300
IEPRDVALAR AVILYNAMKC GNMSLISPDY DRILDCFQRA DADALRENEW
310 320 330 340 350
APVREFGDFP WVPVVDGDFL LENAQTSLKQ GNFKKTQLLA GSNRDESIYF
360 370 380 390 400
LTYQLPDIFP VADFFSKSEF IKDRQTWIKG VKDLLPRQIL KCQLTLAAVL
410 420 430 440 450
HEYEPQDLPI SAQNWLNAMD KMLGDYHFTC SVNEMALAHT KHGGDTFYYY
460 470 480 490 500
FTHRATQQTW PEWMGVLHGY EINFIFGEPF NQKRFNYTDE ERELSNRFMR
510 520 530 540 550
YWANFAKTGD PNKNEDGSFT QDIWPKYNSV SMEYMNMTVE SSYPGQNRIG
560 570 580 590 600
HGPRRKECAF WKAYLPNLMA AVADVGDPYL VWKQQMDKWQ NEYITDWQYH
610 620
FEQYKRYQTY RQSDSETCGG
Length:620
Mass (Da):71,501
Last modified:November 1, 1996 - v1
Checksum:i69D73CD3996E11FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41846 Genomic DNA. Translation: AAB41269.1.
HE600961 Genomic DNA. Translation: CAP34096.1.
RefSeqiXP_002643631.1. XM_002643585.1.

Genome annotation databases

EnsemblMetazoaiCBG16374; CBG16374; CBG16374.
GeneIDi8585625.
KEGGicbr:CBG16374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41846 Genomic DNA. Translation: AAB41269.1.
HE600961 Genomic DNA. Translation: CAP34096.1.
RefSeqiXP_002643631.1. XM_002643585.1.

3D structure databases

ProteinModelPortaliQ27459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG16374.

Protein family/group databases

MEROPSiS09.979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG16374; CBG16374; CBG16374.
GeneIDi8585625.
KEGGicbr:CBG16374.

Organism-specific databases

CTDi8585625.
WormBaseiCBG16374; CBP03902; WBGene00036330; Cbr-ace-1.

Phylogenomic databases

eggNOGiCOG2272.
HOGENOMiHOG000091866.
InParanoidiQ27459.
KOiK01049.
OMAiSFNAPWA.
OrthoDBiEOG789C9R.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparison of ACE-1, the gene encoding acetylcholinesterase of class A, in the two nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
    Grauso M., Culetto E., Berge J.-B., Toutant J.-P., Arpagaus M.
    DNA Seq. 6:217-227(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACE1_CAEBR
AccessioniPrimary (citable) accession number: Q27459
Secondary accession number(s): A8XNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.