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Q27459

- ACE1_CAEBR

UniProt

Q27459 - ACE1_CAEBR

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Protein

Acetylcholinesterase 1

Gene
ace-1, CBG16374
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Rapidly hydrolyzes choline released into the synapse.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei216 – 2161Acyl-ester intermediate By similarity
Active sitei346 – 3461Charge relay system By similarity
Active sitei468 – 4681Charge relay system By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase 1 (EC:3.1.1.7)
Short name:
AChE 1
Gene namesi
Name:ace-1
ORF Names:CBG16374
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG16374; CBP03902; WBGene00036330; Cbr-ace-1.

Subcellular locationi

Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane; Peripheral membrane protein By similarity
Note: May be secreted or membrane associated via a non-catalytic subunit By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 620589Acetylcholinesterase 1PRO_0000008609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi82 ↔ 109 By similarity
Disulfide bondi270 ↔ 286 By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi430 ↔ 558 By similarity
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi536 – 5361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi618 – 618Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Oligomer composed of disulfide-linked homodimers By similarity.

Protein-protein interaction databases

STRINGi6238.CBG16374.

Structurei

3D structure databases

ProteinModelPortaliQ27459.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
HOGENOMiHOG000091866.
KOiK01049.
OMAiSFNAPWA.
OrthoDBiEOG789C9R.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27459-1 [UniParc]FASTAAdd to Basket

« Hide

MRYSLLFFIF LPCVITAVDL IHLHDGSPLF GEEVLSQTGK PLTRFLGIPF    50
AEPPIGNLRF RKPKPKQPWR IPFNATTPPN SCIQSEDTYF GDFYGSTMWN 100
PNTKLSEDCL YLNVYVPGKV DPNKKLAVMI WVYGGGFWSG TSTLDVYDGR 150
ILTVEENVIL VAMNYRVSIF GFLYMNRSEA PGNMGMWDQL LAMKWVHKNI 200
DLFGGDTSRI TLFGESAGAA SVSIHMLSQK SAPYFHRAII QSGSATSPWA 250
IEPRDVALAR AVILYNAMKC GNMSLISPDY DRILDCFQRA DADALRENEW 300
APVREFGDFP WVPVVDGDFL LENAQTSLKQ GNFKKTQLLA GSNRDESIYF 350
LTYQLPDIFP VADFFSKSEF IKDRQTWIKG VKDLLPRQIL KCQLTLAAVL 400
HEYEPQDLPI SAQNWLNAMD KMLGDYHFTC SVNEMALAHT KHGGDTFYYY 450
FTHRATQQTW PEWMGVLHGY EINFIFGEPF NQKRFNYTDE ERELSNRFMR 500
YWANFAKTGD PNKNEDGSFT QDIWPKYNSV SMEYMNMTVE SSYPGQNRIG 550
HGPRRKECAF WKAYLPNLMA AVADVGDPYL VWKQQMDKWQ NEYITDWQYH 600
FEQYKRYQTY RQSDSETCGG 620
Length:620
Mass (Da):71,501
Last modified:November 1, 1996 - v1
Checksum:i69D73CD3996E11FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41846 Genomic DNA. Translation: AAB41269.1.
HE600961 Genomic DNA. Translation: CAP34096.1.
RefSeqiXP_002643631.1. XM_002643585.1.

Genome annotation databases

EnsemblMetazoaiCBG16374; CBG16374; CBG16374.
GeneIDi8585625.
KEGGicbr:CBG16374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41846 Genomic DNA. Translation: AAB41269.1 .
HE600961 Genomic DNA. Translation: CAP34096.1 .
RefSeqi XP_002643631.1. XM_002643585.1.

3D structure databases

ProteinModelPortali Q27459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG16374.

Protein family/group databases

MEROPSi S09.979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG16374 ; CBG16374 ; CBG16374 .
GeneIDi 8585625.
KEGGi cbr:CBG16374.

Organism-specific databases

CTDi 8585625.
WormBasei CBG16374 ; CBP03902 ; WBGene00036330 ; Cbr-ace-1.

Phylogenomic databases

eggNOGi COG2272.
HOGENOMi HOG000091866.
KOi K01049.
OMAi SFNAPWA.
OrthoDBi EOG789C9R.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
ProDomi PD415333. AChE_tetra. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparison of ACE-1, the gene encoding acetylcholinesterase of class A, in the two nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
    Grauso M., Culetto E., Berge J.-B., Toutant J.-P., Arpagaus M.
    DNA Seq. 6:217-227(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACE1_CAEBR
AccessioniPrimary (citable) accession number: Q27459
Secondary accession number(s): A8XNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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